Vitamin E Bioavailability: Mechanisms of Intestinal Absorption in the Spotlight
Vitamin E is an essential fat-soluble micronutrient whose effects on human health can be attributed to both antioxidant and non-antioxidant properties. A growing number of studies aim to promote vitamin E bioavailability in foods. It is thus of major interest to gain deeper insight into the mechanis...
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| Format: | Article |
| Language: | English |
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MDPI AG
2017-11-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/6/4/95 |
| _version_ | 1827843946694311936 |
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| author | Emmanuelle Reboul |
| author_facet | Emmanuelle Reboul |
| author_sort | Emmanuelle Reboul |
| collection | DOAJ |
| description | Vitamin E is an essential fat-soluble micronutrient whose effects on human health can be attributed to both antioxidant and non-antioxidant properties. A growing number of studies aim to promote vitamin E bioavailability in foods. It is thus of major interest to gain deeper insight into the mechanisms of vitamin E absorption, which remain only partly understood. It was long assumed that vitamin E was absorbed by passive diffusion, but recent data has shown that this process is actually far more complex than previously thought. This review describes the fate of vitamin E in the human gastrointestinal lumen during digestion and focuses on the proteins involved in the intestinal membrane and cellular transport of vitamin E across the enterocyte. Special attention is also given to the factors modulating both vitamin E micellarization and absorption. Although these latest results significantly improve our understanding of vitamin E intestinal absorption, further studies are still needed to decipher the molecular mechanisms driving this multifaceted process. |
| first_indexed | 2024-03-12T08:34:08Z |
| format | Article |
| id | doaj.art-abdf47dd410c4f5eb20d79d9dd1eb5d1 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-12T08:34:08Z |
| publishDate | 2017-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-abdf47dd410c4f5eb20d79d9dd1eb5d12023-09-02T17:24:28ZengMDPI AGAntioxidants2076-39212017-11-01649510.3390/antiox6040095antiox6040095Vitamin E Bioavailability: Mechanisms of Intestinal Absorption in the SpotlightEmmanuelle Reboul0Aix Marseille University, INRA, INSERM, C2VN, 13005 Marseille, FranceVitamin E is an essential fat-soluble micronutrient whose effects on human health can be attributed to both antioxidant and non-antioxidant properties. A growing number of studies aim to promote vitamin E bioavailability in foods. It is thus of major interest to gain deeper insight into the mechanisms of vitamin E absorption, which remain only partly understood. It was long assumed that vitamin E was absorbed by passive diffusion, but recent data has shown that this process is actually far more complex than previously thought. This review describes the fate of vitamin E in the human gastrointestinal lumen during digestion and focuses on the proteins involved in the intestinal membrane and cellular transport of vitamin E across the enterocyte. Special attention is also given to the factors modulating both vitamin E micellarization and absorption. Although these latest results significantly improve our understanding of vitamin E intestinal absorption, further studies are still needed to decipher the molecular mechanisms driving this multifaceted process.https://www.mdpi.com/2076-3921/6/4/95tocopherolintestinemixed micellesdietary lipidsfood matrixmembrane transportersuptakeenterocyteschylomicronsHDLfat-soluble vitamins |
| spellingShingle | Emmanuelle Reboul Vitamin E Bioavailability: Mechanisms of Intestinal Absorption in the Spotlight Antioxidants tocopherol intestine mixed micelles dietary lipids food matrix membrane transporters uptake enterocytes chylomicrons HDL fat-soluble vitamins |
| title | Vitamin E Bioavailability: Mechanisms of Intestinal Absorption in the Spotlight |
| title_full | Vitamin E Bioavailability: Mechanisms of Intestinal Absorption in the Spotlight |
| title_fullStr | Vitamin E Bioavailability: Mechanisms of Intestinal Absorption in the Spotlight |
| title_full_unstemmed | Vitamin E Bioavailability: Mechanisms of Intestinal Absorption in the Spotlight |
| title_short | Vitamin E Bioavailability: Mechanisms of Intestinal Absorption in the Spotlight |
| title_sort | vitamin e bioavailability mechanisms of intestinal absorption in the spotlight |
| topic | tocopherol intestine mixed micelles dietary lipids food matrix membrane transporters uptake enterocytes chylomicrons HDL fat-soluble vitamins |
| url | https://www.mdpi.com/2076-3921/6/4/95 |
| work_keys_str_mv | AT emmanuellereboul vitaminebioavailabilitymechanismsofintestinalabsorptioninthespotlight |