Dataset supporting the proteomic characterization of human corneal epithelial cells with HSV-1 infection
HSV-1 infection in cornea can cause corneal ulcer, scar formation and neovascularization, and finally lead to severe visual impairment. The corneal epithelium is the first barrier against HSV-1 infection, but the host-virus interaction in human corneal epithelial cells (HCECs) in the process is stil...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2019-12-01
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| Series: | Data in Brief |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352340919309345 |
| _version_ | 1811226247790854144 |
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| author | Zhi-Yi Xu Jia-Hui Li Mei-Jun Li Wen-Lin Zheng Hong-Wei Pan |
| author_facet | Zhi-Yi Xu Jia-Hui Li Mei-Jun Li Wen-Lin Zheng Hong-Wei Pan |
| author_sort | Zhi-Yi Xu |
| collection | DOAJ |
| description | HSV-1 infection in cornea can cause corneal ulcer, scar formation and neovascularization, and finally lead to severe visual impairment. The corneal epithelium is the first barrier against HSV-1 infection, but the host-virus interaction in human corneal epithelial cells (HCECs) in the process is still not well understood. We applied iTRAQ based proteomic approach to investigate the dynamic change of the protein expression profile in HCECs with a view to gain insight into the host response to HSV-1 infection. Bioinformatic analysis of these dysregulated proteins help us to find the potential gene function and signaling pathway with which these dysregulated proteins are associated. In this work, we present the supporting information for the proteomic characterization for better share and reuse. The main methodological approaches and major findings of the proteomic experiments are described in [1]. Keywords: HSV-1, Corneal epithelial cell, Proteomics, iTRAQ, MRM, Bioinformatic analysis |
| first_indexed | 2024-04-12T09:21:49Z |
| format | Article |
| id | doaj.art-abe0e5df1eb7464e9357e03121ddaa68 |
| institution | Directory Open Access Journal |
| issn | 2352-3409 |
| language | English |
| last_indexed | 2024-04-12T09:21:49Z |
| publishDate | 2019-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Data in Brief |
| spelling | doaj.art-abe0e5df1eb7464e9357e03121ddaa682022-12-22T03:38:36ZengElsevierData in Brief2352-34092019-12-0127Dataset supporting the proteomic characterization of human corneal epithelial cells with HSV-1 infectionZhi-Yi Xu0Jia-Hui Li1Mei-Jun Li2Wen-Lin Zheng3Hong-Wei Pan4Department of Ophthalmology, The First Affiliated Hospital, Jinan University, Guangzhou, China; Institute of Ophthalmology, School of Medicine, Jinan University, Guangzhou, ChinaDepartment of Public Health and Preventive Medicine, Jinan University, Guangzhou, ChinaDepartment of Ophthalmology, The First Affiliated Hospital, Jinan University, Guangzhou, China; Institute of Ophthalmology, School of Medicine, Jinan University, Guangzhou, ChinaDepartment of Public Health and Preventive Medicine, Jinan University, Guangzhou, ChinaDepartment of Ophthalmology, The First Affiliated Hospital, Jinan University, Guangzhou, China; Institute of Ophthalmology, School of Medicine, Jinan University, Guangzhou, China; Department of Public Health and Preventive Medicine, Jinan University, Guangzhou, China; Corresponding author. Department of Ophthalmology, The First Affiliated Hospital, Jinan University, Guangzhou, China.HSV-1 infection in cornea can cause corneal ulcer, scar formation and neovascularization, and finally lead to severe visual impairment. The corneal epithelium is the first barrier against HSV-1 infection, but the host-virus interaction in human corneal epithelial cells (HCECs) in the process is still not well understood. We applied iTRAQ based proteomic approach to investigate the dynamic change of the protein expression profile in HCECs with a view to gain insight into the host response to HSV-1 infection. Bioinformatic analysis of these dysregulated proteins help us to find the potential gene function and signaling pathway with which these dysregulated proteins are associated. In this work, we present the supporting information for the proteomic characterization for better share and reuse. The main methodological approaches and major findings of the proteomic experiments are described in [1]. Keywords: HSV-1, Corneal epithelial cell, Proteomics, iTRAQ, MRM, Bioinformatic analysishttp://www.sciencedirect.com/science/article/pii/S2352340919309345 |
| spellingShingle | Zhi-Yi Xu Jia-Hui Li Mei-Jun Li Wen-Lin Zheng Hong-Wei Pan Dataset supporting the proteomic characterization of human corneal epithelial cells with HSV-1 infection Data in Brief |
| title | Dataset supporting the proteomic characterization of human corneal epithelial cells with HSV-1 infection |
| title_full | Dataset supporting the proteomic characterization of human corneal epithelial cells with HSV-1 infection |
| title_fullStr | Dataset supporting the proteomic characterization of human corneal epithelial cells with HSV-1 infection |
| title_full_unstemmed | Dataset supporting the proteomic characterization of human corneal epithelial cells with HSV-1 infection |
| title_short | Dataset supporting the proteomic characterization of human corneal epithelial cells with HSV-1 infection |
| title_sort | dataset supporting the proteomic characterization of human corneal epithelial cells with hsv 1 infection |
| url | http://www.sciencedirect.com/science/article/pii/S2352340919309345 |
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