Minichromosome maintenance 2 and 5 expressions are increased in the epithelium of hereditary gingival fibromatosis associated with dental abnormalities
INTRODUCTION: Gingiva fibromatosis is a relatively rare condition characterized by diffuse enlargement of the gingiva, which is caused by expansion and accumulation of the connective tissue. OBJECTIVE: The aim of the present study was to investigate proliferative and apoptotic biomarker expression i...
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Format: | Article |
Language: | English |
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Elsevier España
2011-01-01
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Series: | Clinics |
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Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322011000500008 |
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author | Hercílio Martelli-Júnior Carolina de Oliveira Santos Paulo Rogério Bonan Paula de Figueiredo Moura Carolina Cavalcante Bitu Jorge Esquiche León Ricardo D. Coletta |
author_facet | Hercílio Martelli-Júnior Carolina de Oliveira Santos Paulo Rogério Bonan Paula de Figueiredo Moura Carolina Cavalcante Bitu Jorge Esquiche León Ricardo D. Coletta |
author_sort | Hercílio Martelli-Júnior |
collection | DOAJ |
description | INTRODUCTION: Gingiva fibromatosis is a relatively rare condition characterized by diffuse enlargement of the gingiva, which is caused by expansion and accumulation of the connective tissue. OBJECTIVE: The aim of the present study was to investigate proliferative and apoptotic biomarker expression in normal gingiva and two forms of gingival fibromatosis. METHODS: Archived tissue specimens of hereditary gingival fibromatosis, gingival fibromatosis and dental abnormality syndrome and normal gingiva were subject to morphological analysis and immunohistochemical staining. The results were analyzed statistically. RESULTS: Proteins associated with proliferation were found in the nuclei of epithelial cells from the basal and suprabasal layers, whereas apoptotic proteins were detected in the cytoplasm of the upper layers of the epithelium. Increased expressions of minichromosome maintenance proteins 2 and 5 were observed in the gingival fibromatosis and dental abnormality syndrome samples. In contrast, geminin expression was higher in normal gingiva samples. No difference in the expression of apoptotic proteins was observed among the groups. CONCLUSION: Our findings support a role for augmented proliferation of epithelial cells within the overgrown tissues associated with gingival fibromatosis or dental abnormality syndrome. However, our data suggest that different biological mechanisms may account for the pathogenesis of different types of gingival fibromatosis. |
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institution | Directory Open Access Journal |
issn | 1807-5932 1980-5322 |
language | English |
last_indexed | 2024-04-12T10:27:18Z |
publishDate | 2011-01-01 |
publisher | Elsevier España |
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series | Clinics |
spelling | doaj.art-abe1161d5b954e7ab13f11cb8b83f0fd2022-12-22T03:36:56ZengElsevier EspañaClinics1807-59321980-53222011-01-0166575375710.1590/S1807-59322011000500008Minichromosome maintenance 2 and 5 expressions are increased in the epithelium of hereditary gingival fibromatosis associated with dental abnormalitiesHercílio Martelli-JúniorCarolina de Oliveira SantosPaulo Rogério BonanPaula de Figueiredo MouraCarolina Cavalcante BituJorge Esquiche LeónRicardo D. ColettaINTRODUCTION: Gingiva fibromatosis is a relatively rare condition characterized by diffuse enlargement of the gingiva, which is caused by expansion and accumulation of the connective tissue. OBJECTIVE: The aim of the present study was to investigate proliferative and apoptotic biomarker expression in normal gingiva and two forms of gingival fibromatosis. METHODS: Archived tissue specimens of hereditary gingival fibromatosis, gingival fibromatosis and dental abnormality syndrome and normal gingiva were subject to morphological analysis and immunohistochemical staining. The results were analyzed statistically. RESULTS: Proteins associated with proliferation were found in the nuclei of epithelial cells from the basal and suprabasal layers, whereas apoptotic proteins were detected in the cytoplasm of the upper layers of the epithelium. Increased expressions of minichromosome maintenance proteins 2 and 5 were observed in the gingival fibromatosis and dental abnormality syndrome samples. In contrast, geminin expression was higher in normal gingiva samples. No difference in the expression of apoptotic proteins was observed among the groups. CONCLUSION: Our findings support a role for augmented proliferation of epithelial cells within the overgrown tissues associated with gingival fibromatosis or dental abnormality syndrome. However, our data suggest that different biological mechanisms may account for the pathogenesis of different types of gingival fibromatosis.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322011000500008Gingival FibromatosisProliferationApoptosisMinichromosome MaintenanceGeminin |
spellingShingle | Hercílio Martelli-Júnior Carolina de Oliveira Santos Paulo Rogério Bonan Paula de Figueiredo Moura Carolina Cavalcante Bitu Jorge Esquiche León Ricardo D. Coletta Minichromosome maintenance 2 and 5 expressions are increased in the epithelium of hereditary gingival fibromatosis associated with dental abnormalities Clinics Gingival Fibromatosis Proliferation Apoptosis Minichromosome Maintenance Geminin |
title | Minichromosome maintenance 2 and 5 expressions are increased in the epithelium of hereditary gingival fibromatosis associated with dental abnormalities |
title_full | Minichromosome maintenance 2 and 5 expressions are increased in the epithelium of hereditary gingival fibromatosis associated with dental abnormalities |
title_fullStr | Minichromosome maintenance 2 and 5 expressions are increased in the epithelium of hereditary gingival fibromatosis associated with dental abnormalities |
title_full_unstemmed | Minichromosome maintenance 2 and 5 expressions are increased in the epithelium of hereditary gingival fibromatosis associated with dental abnormalities |
title_short | Minichromosome maintenance 2 and 5 expressions are increased in the epithelium of hereditary gingival fibromatosis associated with dental abnormalities |
title_sort | minichromosome maintenance 2 and 5 expressions are increased in the epithelium of hereditary gingival fibromatosis associated with dental abnormalities |
topic | Gingival Fibromatosis Proliferation Apoptosis Minichromosome Maintenance Geminin |
url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322011000500008 |
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