Statin use in cirrhotic patients with infectious diseases: A population-based study.
<h4>Background</h4>Recent studies have shown benefits of statins in patients with liver cirrhosis. However, it is still unknown if statins have a beneficial effect on the mortality of cirrhotic patients with bacterial infections.<h4>Methods</h4>The Taiwan National Health Insu...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2019-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0215839 |
| _version_ | 1819142654249664512 |
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| author | Tsung-Hsing Hung Chih-Chun Tsai Hsing-Feng Lee |
| author_facet | Tsung-Hsing Hung Chih-Chun Tsai Hsing-Feng Lee |
| author_sort | Tsung-Hsing Hung |
| collection | DOAJ |
| description | <h4>Background</h4>Recent studies have shown benefits of statins in patients with liver cirrhosis. However, it is still unknown if statins have a beneficial effect on the mortality of cirrhotic patients with bacterial infections.<h4>Methods</h4>The Taiwan National Health Insurance Database was searched, and 816 cirrhotic patients receiving statins with bacterial infections hospitalized between January 1, 2010 and December 31, 2013 were included in the study. A one-to-four propensity score matching was performed to select a comparison group based on age, sex, and comorbid disorders.<h4>Results</h4>The overall 30-day mortalities in statin and non-statin group were 5.3% and 9.8%, respectively (P = 0.001). After Cox regression modeling adjusting for age, sex, and comorbid disorders, the hazard ratio (HR) of statin use on 30-day mortality was 0.52 (95% confidence interval [CI]: 0.38-0.72, P<0.001). In subgroup analysis, the 30-day mortality effect of statin use was more pronounced in patients with pneumonia (HR = 0.34; 95% CI: 0.19-0.59; P<0.001) and bacteremia (HR = 0.55; 95% CI: 0.35-0.85; P = 0.008). Atovastatin (HR = 0.59; 95% CI: 0.37-0.93) and rosuvastatin (HR = 0.59; 95% CI: 0.36-0.98) were associated with a decreased 30-day mortality risk compared to patients not taking statins.<h4>Conclusions</h4>Statin use decreases the 30-day mortality of cirrhotic patients with bacteremia and pneumonia. |
| first_indexed | 2024-12-22T12:13:47Z |
| format | Article |
| id | doaj.art-abe2fe3d0ed04683a1769c3c0605b774 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-22T12:13:47Z |
| publishDate | 2019-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-abe2fe3d0ed04683a1769c3c0605b7742022-12-21T18:26:13ZengPublic Library of Science (PLoS)PLoS ONE1932-62032019-01-01144e021583910.1371/journal.pone.0215839Statin use in cirrhotic patients with infectious diseases: A population-based study.Tsung-Hsing HungChih-Chun TsaiHsing-Feng Lee<h4>Background</h4>Recent studies have shown benefits of statins in patients with liver cirrhosis. However, it is still unknown if statins have a beneficial effect on the mortality of cirrhotic patients with bacterial infections.<h4>Methods</h4>The Taiwan National Health Insurance Database was searched, and 816 cirrhotic patients receiving statins with bacterial infections hospitalized between January 1, 2010 and December 31, 2013 were included in the study. A one-to-four propensity score matching was performed to select a comparison group based on age, sex, and comorbid disorders.<h4>Results</h4>The overall 30-day mortalities in statin and non-statin group were 5.3% and 9.8%, respectively (P = 0.001). After Cox regression modeling adjusting for age, sex, and comorbid disorders, the hazard ratio (HR) of statin use on 30-day mortality was 0.52 (95% confidence interval [CI]: 0.38-0.72, P<0.001). In subgroup analysis, the 30-day mortality effect of statin use was more pronounced in patients with pneumonia (HR = 0.34; 95% CI: 0.19-0.59; P<0.001) and bacteremia (HR = 0.55; 95% CI: 0.35-0.85; P = 0.008). Atovastatin (HR = 0.59; 95% CI: 0.37-0.93) and rosuvastatin (HR = 0.59; 95% CI: 0.36-0.98) were associated with a decreased 30-day mortality risk compared to patients not taking statins.<h4>Conclusions</h4>Statin use decreases the 30-day mortality of cirrhotic patients with bacteremia and pneumonia.https://doi.org/10.1371/journal.pone.0215839 |
| spellingShingle | Tsung-Hsing Hung Chih-Chun Tsai Hsing-Feng Lee Statin use in cirrhotic patients with infectious diseases: A population-based study. PLoS ONE |
| title | Statin use in cirrhotic patients with infectious diseases: A population-based study. |
| title_full | Statin use in cirrhotic patients with infectious diseases: A population-based study. |
| title_fullStr | Statin use in cirrhotic patients with infectious diseases: A population-based study. |
| title_full_unstemmed | Statin use in cirrhotic patients with infectious diseases: A population-based study. |
| title_short | Statin use in cirrhotic patients with infectious diseases: A population-based study. |
| title_sort | statin use in cirrhotic patients with infectious diseases a population based study |
| url | https://doi.org/10.1371/journal.pone.0215839 |
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