GNAS, PDE4D, and PRKAR1A Mutations and GNAS Methylation Changes Are Not a Common Cause of Isolated Early-Onset Severe Obesity Among Finnish Children

GNAS, PDE4D, and PRKAR1A Mutations and GNAS Methylation Changes Are Not a Common Cause of Isolated Early-Onset Severe Obesity Among Finnish Children

Context: Pseudohypoparathyroidism type Ia (PHP1A) is caused by inactivating mutations involving GNAS exons 1–13, encoding the alpha-subunit of the stimulatory G protein (Gsα). Particularly PHP1A, but also other disorders involving the Gsα-cAMP-signaling pathway, have been associated with early-onset...

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Bibliographic Details
Main Authors: Petra Loid, Minna Pekkinen, Monica Reyes, Taina Mustila, Heli Viljakainen, Harald Jüppner, Outi Mäkitie
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Pediatrics
Subjects:
GNAS
G protein-cAMP-signaling
childhood-onset obesity
pseudohypoparathyroidism
acrodysostosis
Online Access:https://www.frontiersin.org/article/10.3389/fped.2020.00145/full

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