LHPP-mediated inorganic pyrophosphate hydrolysis-driven lysosomal acidification in astrocytes regulates adult neurogenesis

LHPP-mediated inorganic pyrophosphate hydrolysis-driven lysosomal acidification in astrocytes regulates adult neurogenesis

Summary: In bacteria, archaea, protists, and plants, the hydrolysis of pyrophosphate (PPi) by inorganic pyrophosphatase (PPase) can, under stress conditions, substitute for ATP-driven proton flux to generate a proton gradient and induce luminal acidification. However, this strategy is considered to...

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Bibliographic Details
Main Authors: Longze Sha, Jing Li, Hui Shen, Qingyu Wang, Peixin Meng, Xiuneng Zhang, Yu Deng, Wanwan Zhu, Qi Xu
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:Cell Reports
Subjects:
CP: Cell biology
CP: Neuroscience
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723009865

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