Comorbidities of primary headache disorders: a literature review with meta-analysis
Abstract Background Primary headache disorders are common and burdensome conditions. They are associated to several comorbidities, such as cardiovascular or psychiatric ones, which, in turn, contribute to the global burden of headache. The aim of this study is to provide a comprehensive description...
| Main Authors: | , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2021-07-01
|
| Series: | The Journal of Headache and Pain |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s10194-021-01281-z |
| _version_ | 1818891317176958976 |
|---|---|
| author | Valeria Caponnetto Manuela Deodato Micaela Robotti Maria Koutsokera Valeria Pozzilli Cristina Galati Giovanna Nocera Eleonora De Matteis Gioacchino De Vanna Emanuela Fellini Gleni Halili Daniele Martinelli Gabriele Nalli Serena Serratore Irene Tramacere Paolo Martelletti Alberto Raggi On behalf of the European Headache Federation School of Advanced Studies (EHF-SAS) |
| author_facet | Valeria Caponnetto Manuela Deodato Micaela Robotti Maria Koutsokera Valeria Pozzilli Cristina Galati Giovanna Nocera Eleonora De Matteis Gioacchino De Vanna Emanuela Fellini Gleni Halili Daniele Martinelli Gabriele Nalli Serena Serratore Irene Tramacere Paolo Martelletti Alberto Raggi On behalf of the European Headache Federation School of Advanced Studies (EHF-SAS) |
| author_sort | Valeria Caponnetto |
| collection | DOAJ |
| description | Abstract Background Primary headache disorders are common and burdensome conditions. They are associated to several comorbidities, such as cardiovascular or psychiatric ones, which, in turn, contribute to the global burden of headache. The aim of this study is to provide a comprehensive description of the pooled prevalence of comorbidities of primary headache disorders using a meta-analytical approach based on studies published between 2000 and 2020. Methods Scopus was searched for primary research (clinical and population studies) in which medical comorbidities were described in adults with primary headache disorders. Comorbidities were extracted using a taxonomy derived from the Global Burden of Disease (GBD) study. We compared prevalence of comorbidities among headache sufferers against general population using GBD-2019 estimates, and compared comorbidities’ proportions in clinical vs. population studies, and by age and gender. Results A total of 139 studies reporting information on 4.19 million subjects with primary headaches were included: in total 2.75 million comorbidities were reported (median per subject 0.64, interquartile range 0.32–1.07). The most frequently addressed comorbidities were: depressive disorders, addressed in 51 studies (pooled proportion 23 %, 95 % CI 20–26 %); hypertension, addressed in 48 studies (pooled proportion 24 %, 95 % CI 22–26 %); anxiety disorders addressed in 40 studies (pooled proportion 25 %, 95 % CI 22–28 %). For conditions such as anxiety, depression and back pain, prevalence among headache sufferers was higher than in GBD-2109 estimates. Associations with average age and female prevalence within studies showed that hypertension was more frequent in studies with higher age and less females, whereas fibromyalgia, restless leg syndrome, and depressive disorders were more frequent in studies with younger age and more female. Conclusions Some of the most relevant comorbidities of primary headache disorders – back pain, anxiety and depression, diabetes, ischemic heart disease and stroke – are among the most burdensome conditions, together with headache themselves, according to the GBD study. A joint treatment of headaches and of these comorbidities may positively impact on headache sufferers’ health status and contribute to reduce the impact of a group of highly burdensome diseases. |
| first_indexed | 2024-12-19T17:38:53Z |
| format | Article |
| id | doaj.art-abe923e49b284e12b9b88342f8b15bb6 |
| institution | Directory Open Access Journal |
| issn | 1129-2369 1129-2377 |
| language | English |
| last_indexed | 2024-12-19T17:38:53Z |
| publishDate | 2021-07-01 |
| publisher | BMC |
| record_format | Article |
| series | The Journal of Headache and Pain |
| spelling | doaj.art-abe923e49b284e12b9b88342f8b15bb62022-12-21T20:12:16ZengBMCThe Journal of Headache and Pain1129-23691129-23772021-07-0122111810.1186/s10194-021-01281-zComorbidities of primary headache disorders: a literature review with meta-analysisValeria Caponnetto0Manuela Deodato1Micaela Robotti2Maria Koutsokera3Valeria Pozzilli4Cristina Galati5Giovanna Nocera6Eleonora De Matteis7Gioacchino De Vanna8Emanuela Fellini9Gleni Halili10Daniele Martinelli11Gabriele Nalli12Serena Serratore13Irene Tramacere14Paolo Martelletti15Alberto Raggi16On behalf of the European Headache Federation School of Advanced Studies (EHF-SAS)SS Filippo & Nicola Hospital , University of L’AquilaDepartment of Life Sciences, University of TriesteCentro di Diagnosi e Cura delle Cefalee, Palazzo della Salute, Gruppo San DonatoThriassio General Hospital of ElefsinaInternal Medicine Unit, Department of Clinical and Molecular Medicine, Sapienza UniversityUO Neuropsichiatria Infantile, Policlinico Universitario Paolo Giaccone, Università degli Studi di PalermoUO Neuropsichiatria Infantile, Policlinico Universitario Paolo Giaccone, Università degli Studi di PalermoNeuroscience Section, Department of Applied Clinical Sciences and Biotechnology, University of L’AquilaClinica Neurologica, Dipartimento di Medicina, Università degli Studi di PerugiaInternal Medicine Unit, Department of Clinical and Molecular Medicine, Sapienza UniversityDepartment of Neurology, University Hospital Center ‘Mother Teresa’Department of Brain and Behavioral Sciences, University of PaviaInternal Medicine Unit, Department of Clinical and Molecular Medicine, Sapienza UniversityInternal Medicine Unit, Department of Clinical and Molecular Medicine, Sapienza UniversityDipartimento di Ricerca e Sviluppo Clinico, Fondazione IRCCS Istituto Neurologico Carlo BestaDepartment of Clinical and Molecular Medicine, Sapienza UniversityUOC Neurologia, Salute Pubblica, Disabilità, Fondazione IRCCS Istituto Neurologico Carlo BestaAbstract Background Primary headache disorders are common and burdensome conditions. They are associated to several comorbidities, such as cardiovascular or psychiatric ones, which, in turn, contribute to the global burden of headache. The aim of this study is to provide a comprehensive description of the pooled prevalence of comorbidities of primary headache disorders using a meta-analytical approach based on studies published between 2000 and 2020. Methods Scopus was searched for primary research (clinical and population studies) in which medical comorbidities were described in adults with primary headache disorders. Comorbidities were extracted using a taxonomy derived from the Global Burden of Disease (GBD) study. We compared prevalence of comorbidities among headache sufferers against general population using GBD-2019 estimates, and compared comorbidities’ proportions in clinical vs. population studies, and by age and gender. Results A total of 139 studies reporting information on 4.19 million subjects with primary headaches were included: in total 2.75 million comorbidities were reported (median per subject 0.64, interquartile range 0.32–1.07). The most frequently addressed comorbidities were: depressive disorders, addressed in 51 studies (pooled proportion 23 %, 95 % CI 20–26 %); hypertension, addressed in 48 studies (pooled proportion 24 %, 95 % CI 22–26 %); anxiety disorders addressed in 40 studies (pooled proportion 25 %, 95 % CI 22–28 %). For conditions such as anxiety, depression and back pain, prevalence among headache sufferers was higher than in GBD-2109 estimates. Associations with average age and female prevalence within studies showed that hypertension was more frequent in studies with higher age and less females, whereas fibromyalgia, restless leg syndrome, and depressive disorders were more frequent in studies with younger age and more female. Conclusions Some of the most relevant comorbidities of primary headache disorders – back pain, anxiety and depression, diabetes, ischemic heart disease and stroke – are among the most burdensome conditions, together with headache themselves, according to the GBD study. A joint treatment of headaches and of these comorbidities may positively impact on headache sufferers’ health status and contribute to reduce the impact of a group of highly burdensome diseases.https://doi.org/10.1186/s10194-021-01281-zPrimary headacheMigraineTTHCHComorbidityDepression |
| spellingShingle | Valeria Caponnetto Manuela Deodato Micaela Robotti Maria Koutsokera Valeria Pozzilli Cristina Galati Giovanna Nocera Eleonora De Matteis Gioacchino De Vanna Emanuela Fellini Gleni Halili Daniele Martinelli Gabriele Nalli Serena Serratore Irene Tramacere Paolo Martelletti Alberto Raggi On behalf of the European Headache Federation School of Advanced Studies (EHF-SAS) Comorbidities of primary headache disorders: a literature review with meta-analysis The Journal of Headache and Pain Primary headache Migraine TTH CH Comorbidity Depression |
| title | Comorbidities of primary headache disorders: a literature review with meta-analysis |
| title_full | Comorbidities of primary headache disorders: a literature review with meta-analysis |
| title_fullStr | Comorbidities of primary headache disorders: a literature review with meta-analysis |
| title_full_unstemmed | Comorbidities of primary headache disorders: a literature review with meta-analysis |
| title_short | Comorbidities of primary headache disorders: a literature review with meta-analysis |
| title_sort | comorbidities of primary headache disorders a literature review with meta analysis |
| topic | Primary headache Migraine TTH CH Comorbidity Depression |
| url | https://doi.org/10.1186/s10194-021-01281-z |
| work_keys_str_mv | AT valeriacaponnetto comorbiditiesofprimaryheadachedisordersaliteraturereviewwithmetaanalysis AT manueladeodato comorbiditiesofprimaryheadachedisordersaliteraturereviewwithmetaanalysis AT micaelarobotti comorbiditiesofprimaryheadachedisordersaliteraturereviewwithmetaanalysis AT mariakoutsokera comorbiditiesofprimaryheadachedisordersaliteraturereviewwithmetaanalysis AT valeriapozzilli comorbiditiesofprimaryheadachedisordersaliteraturereviewwithmetaanalysis AT cristinagalati comorbiditiesofprimaryheadachedisordersaliteraturereviewwithmetaanalysis AT giovannanocera comorbiditiesofprimaryheadachedisordersaliteraturereviewwithmetaanalysis AT eleonoradematteis comorbiditiesofprimaryheadachedisordersaliteraturereviewwithmetaanalysis AT gioacchinodevanna comorbiditiesofprimaryheadachedisordersaliteraturereviewwithmetaanalysis AT emanuelafellini comorbiditiesofprimaryheadachedisordersaliteraturereviewwithmetaanalysis AT glenihalili comorbiditiesofprimaryheadachedisordersaliteraturereviewwithmetaanalysis AT danielemartinelli comorbiditiesofprimaryheadachedisordersaliteraturereviewwithmetaanalysis AT gabrielenalli comorbiditiesofprimaryheadachedisordersaliteraturereviewwithmetaanalysis AT serenaserratore comorbiditiesofprimaryheadachedisordersaliteraturereviewwithmetaanalysis AT irenetramacere comorbiditiesofprimaryheadachedisordersaliteraturereviewwithmetaanalysis AT paolomartelletti comorbiditiesofprimaryheadachedisordersaliteraturereviewwithmetaanalysis AT albertoraggi comorbiditiesofprimaryheadachedisordersaliteraturereviewwithmetaanalysis AT onbehalfoftheeuropeanheadachefederationschoolofadvancedstudiesehfsas comorbiditiesofprimaryheadachedisordersaliteraturereviewwithmetaanalysis |