Definition and measurement of post-COVID-19 conditions in real-world practice: a global systematic literature review
Methods Medline, EMBASE and the Cochrane Library were searched and supplemented with conference and grey literature searches. Eligible studies included individuals with (1) PCC or (2) a positive SARS-CoV-2 test or COVID-19 diagnosis who were followed over time. Included studies were published in Eng...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2024-01-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/14/1/e077886.full |
| _version_ | 1797295891596443648 |
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| author | Moe H Kyaw Abby E Rudolph Kristen Markus Julia Regazzini Spinardi Jingyan Yang Jennifer L Nguyen Kathleen Michelle Andersen Leah J McGrath Isabelle Whittle Vasileios Blazos Louise Heron |
| author_facet | Moe H Kyaw Abby E Rudolph Kristen Markus Julia Regazzini Spinardi Jingyan Yang Jennifer L Nguyen Kathleen Michelle Andersen Leah J McGrath Isabelle Whittle Vasileios Blazos Louise Heron |
| author_sort | Moe H Kyaw |
| collection | DOAJ |
| description | Methods Medline, EMBASE and the Cochrane Library were searched and supplemented with conference and grey literature searches. Eligible studies included individuals with (1) PCC or (2) a positive SARS-CoV-2 test or COVID-19 diagnosis who were followed over time. Included studies were published in English between 1 January 2020 and 14 November 2022.Findings Of 291 publications included, 175 (60%) followed individuals with confirmed COVID-19 over time for PCC and 116 (40%) used a prespecified PCC definition. There was substantial heterogeneity in study design, geography, age group, PCC conditions/symptoms assessed and their classification and duration of follow-up. Among studies using a prespecified PCC definition, author-defined criteria (51%) were more common than criteria recommended by major public health organisations (19%). Measurement periods for PCC outcomes from date of acute COVID-19 test were primarily 3 to <6 months (39.2%), followed by 6 to <12 months (27.5%) and <3 months (22.9%). When classified by organ/system, constitutional-related PCC were the most frequently assessed in adult (86%) and paediatric (87%) populations. Within constitutional symptoms, fatigue was most frequently assessed in adult (91.6%) and paediatric (95.0%) populations, followed by fever/chills (37.9% and 55%, respectively).Conclusions PCC definitions are heterogenous across real-world studies, which limits reliable comparisons between studies. However, some similarities were observed in terms of the most frequently measured PCC-associated symptoms/conditions, which may aid clinical management of patients with PCC.CRD42022376111. |
| first_indexed | 2024-03-07T21:55:29Z |
| format | Article |
| id | doaj.art-abed3ea824294e71bdda3f13766942e3 |
| institution | Directory Open Access Journal |
| issn | 2044-6055 |
| language | English |
| last_indexed | 2024-03-07T21:55:29Z |
| publishDate | 2024-01-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj.art-abed3ea824294e71bdda3f13766942e32024-02-24T18:35:12ZengBMJ Publishing GroupBMJ Open2044-60552024-01-0114110.1136/bmjopen-2023-077886Definition and measurement of post-COVID-19 conditions in real-world practice: a global systematic literature reviewMoe H Kyaw0Abby E Rudolph1Kristen Markus2Julia Regazzini Spinardi3Jingyan Yang4Jennifer L Nguyen5Kathleen Michelle Andersen6Leah J McGrath7Isabelle Whittle8Vasileios Blazos9Louise Heron10Pfizer Inc, New York, New York, USAPfizer Inc, New York, New York, USAAdelphi Values PROVE, Bollington, UKEmerging Markets, Pfizer Brasil, São Paulo, BrazilInstitute for Social and Economic Research and Policy, Columbia University, New York, New York, USAPfizer Inc, New York, New York, USAPfizer Inc, New York, New York, USAPfizer Inc, New York, New York, USAAdelphi Values PROVE, Bollington, UKAdelphi Values PROVE, Bollington, UKAdelphi Values PROVE, Bollington, UKMethods Medline, EMBASE and the Cochrane Library were searched and supplemented with conference and grey literature searches. Eligible studies included individuals with (1) PCC or (2) a positive SARS-CoV-2 test or COVID-19 diagnosis who were followed over time. Included studies were published in English between 1 January 2020 and 14 November 2022.Findings Of 291 publications included, 175 (60%) followed individuals with confirmed COVID-19 over time for PCC and 116 (40%) used a prespecified PCC definition. There was substantial heterogeneity in study design, geography, age group, PCC conditions/symptoms assessed and their classification and duration of follow-up. Among studies using a prespecified PCC definition, author-defined criteria (51%) were more common than criteria recommended by major public health organisations (19%). Measurement periods for PCC outcomes from date of acute COVID-19 test were primarily 3 to <6 months (39.2%), followed by 6 to <12 months (27.5%) and <3 months (22.9%). When classified by organ/system, constitutional-related PCC were the most frequently assessed in adult (86%) and paediatric (87%) populations. Within constitutional symptoms, fatigue was most frequently assessed in adult (91.6%) and paediatric (95.0%) populations, followed by fever/chills (37.9% and 55%, respectively).Conclusions PCC definitions are heterogenous across real-world studies, which limits reliable comparisons between studies. However, some similarities were observed in terms of the most frequently measured PCC-associated symptoms/conditions, which may aid clinical management of patients with PCC.CRD42022376111.https://bmjopen.bmj.com/content/14/1/e077886.full |
| spellingShingle | Moe H Kyaw Abby E Rudolph Kristen Markus Julia Regazzini Spinardi Jingyan Yang Jennifer L Nguyen Kathleen Michelle Andersen Leah J McGrath Isabelle Whittle Vasileios Blazos Louise Heron Definition and measurement of post-COVID-19 conditions in real-world practice: a global systematic literature review BMJ Open |
| title | Definition and measurement of post-COVID-19 conditions in real-world practice: a global systematic literature review |
| title_full | Definition and measurement of post-COVID-19 conditions in real-world practice: a global systematic literature review |
| title_fullStr | Definition and measurement of post-COVID-19 conditions in real-world practice: a global systematic literature review |
| title_full_unstemmed | Definition and measurement of post-COVID-19 conditions in real-world practice: a global systematic literature review |
| title_short | Definition and measurement of post-COVID-19 conditions in real-world practice: a global systematic literature review |
| title_sort | definition and measurement of post covid 19 conditions in real world practice a global systematic literature review |
| url | https://bmjopen.bmj.com/content/14/1/e077886.full |
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