Risk factors for need of mechanical ventilation in hildren with Influenza A(H1N1)pdm09
Objective: : The pandemic caused by influenza A(H1N1)pdm09 virus peaked between July and August of 2009 in southern Brazil, with the highest incidence in children and young adults. In the post-pandemic period, there was an increase in the incidence of cases during the winter months of 2011 and 2012...
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| Format: | Article |
| Language: | Portuguese |
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Brazilian Society of Pediatrics
2013-09-01
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| Series: | Jornal de Pediatria (Versão em Português) |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2255553613001043 |
| _version_ | 1828159914316398592 |
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| author | Marcelo C. Scotta Rita Mattiello Paulo J.C. Maróstica Marcus H. Jones Letícia G. Martins Gilberto B. Fischer |
| author_facet | Marcelo C. Scotta Rita Mattiello Paulo J.C. Maróstica Marcus H. Jones Letícia G. Martins Gilberto B. Fischer |
| author_sort | Marcelo C. Scotta |
| collection | DOAJ |
| description | Objective: : The pandemic caused by influenza A(H1N1)pdm09 virus peaked between July and August of 2009 in southern Brazil, with the highest incidence in children and young adults. In the post-pandemic period, there was an increase in the incidence of cases during the winter months of 2011 and 2012 in Brazil, similar to seasonal influenza virus. Since infections due to pandemic influenza are still occurring, the present study aimed to investigate the risk factors for worse outcome in children.
Methods: : A retrospective cohort study was performed by reviewing the charts of hospitalized patients younger than 14 years with reverse transcription-polymerase chain reaction (RT-PCR) positive for influenza A(H1N1)pdm09 during the first pandemic wave in six Brazilian tertiary centers. Need for mechanical ventilation was defined as the severity of outcome; age, chronic diseases, bacterial and viral co-detection, chest radiograph findings, and use of oseltamivir were possible predictors.
Results: : In the present study, 120 patients were included. In a multivariate analysis, chronic diseases (prevalence ratio: 2.613, 95% CI: 1.267-5.386) and viral co-detection (prevalence ratio: 2.43, 95% CI: 1.203-4.905) were statistically associated with worse outcome (p < 0.05).
Conclusions: : The presence of chronic diseases as predictors reinforces previous finding. Furthermore, viral co-detection was found to be a risk factor. Further studies are necessary to confirm this association. |
| first_indexed | 2024-04-12T00:08:26Z |
| format | Article |
| id | doaj.art-abede53ae9e34f04bd3e2df109795c40 |
| institution | Directory Open Access Journal |
| issn | 2255-5536 |
| language | Portuguese |
| last_indexed | 2024-04-12T00:08:26Z |
| publishDate | 2013-09-01 |
| publisher | Brazilian Society of Pediatrics |
| record_format | Article |
| series | Jornal de Pediatria (Versão em Português) |
| spelling | doaj.art-abede53ae9e34f04bd3e2df109795c402022-12-22T03:56:01ZporBrazilian Society of PediatricsJornal de Pediatria (Versão em Português)2255-55362013-09-0189544444910.1016/j.jpedp.2013.01.011Risk factors for need of mechanical ventilation in hildren with Influenza A(H1N1)pdm09Marcelo C. Scotta0Rita Mattiello1Paulo J.C. Maróstica2Marcus H. Jones3Letícia G. Martins4Gilberto B. Fischer5Mestrando em Saúde da Criança e do Adolescente, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brasil. Infectologista Pediátrico, Hospital da Criança Santo Antônio, Departamento de Pediatria, Porto Alegre, RS, BrasilProfessora Associada de Pediatria, PhD em Saúde da Criança e do Adolescente, Epidemiologista, Instituto de Pesquisas Biomédicas, Faculdade de Medicina, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, RS, BrasilProfessor Associado de Pediatria, Unidade de Emergência Pediátrica, Hospital de Clínicas de Porto Alegre, UFRGS, Porto Alegre, RS, BrasilProfessor Associado de Pediatria, Instituto de Pesquisas Biomédicas, Faculdade de Medicina, PUCRS, Porto Alegre, RS, BrasilEspecialista em Vigilância em Saúde, Divisão de Vigilância Epidemiológica, Secretaria Estadual da Saúde do Rio Grande do Sul, Porto Alegre, RS, BrasilTitular de Pediatria, Universidade Federal das Ciências da Saúde de Porto Alegre, Porto Alegre, RS, BrasilObjective: : The pandemic caused by influenza A(H1N1)pdm09 virus peaked between July and August of 2009 in southern Brazil, with the highest incidence in children and young adults. In the post-pandemic period, there was an increase in the incidence of cases during the winter months of 2011 and 2012 in Brazil, similar to seasonal influenza virus. Since infections due to pandemic influenza are still occurring, the present study aimed to investigate the risk factors for worse outcome in children. Methods: : A retrospective cohort study was performed by reviewing the charts of hospitalized patients younger than 14 years with reverse transcription-polymerase chain reaction (RT-PCR) positive for influenza A(H1N1)pdm09 during the first pandemic wave in six Brazilian tertiary centers. Need for mechanical ventilation was defined as the severity of outcome; age, chronic diseases, bacterial and viral co-detection, chest radiograph findings, and use of oseltamivir were possible predictors. Results: : In the present study, 120 patients were included. In a multivariate analysis, chronic diseases (prevalence ratio: 2.613, 95% CI: 1.267-5.386) and viral co-detection (prevalence ratio: 2.43, 95% CI: 1.203-4.905) were statistically associated with worse outcome (p < 0.05). Conclusions: : The presence of chronic diseases as predictors reinforces previous finding. Furthermore, viral co-detection was found to be a risk factor. Further studies are necessary to confirm this association.http://www.sciencedirect.com/science/article/pii/S2255553613001043Influenza A H1N1 subtypeRisk factorsRespiratory insufficiencyChild |
| spellingShingle | Marcelo C. Scotta Rita Mattiello Paulo J.C. Maróstica Marcus H. Jones Letícia G. Martins Gilberto B. Fischer Risk factors for need of mechanical ventilation in hildren with Influenza A(H1N1)pdm09 Jornal de Pediatria (Versão em Português) Influenza A H1N1 subtype Risk factors Respiratory insufficiency Child |
| title | Risk factors for need of mechanical ventilation in hildren with Influenza A(H1N1)pdm09 |
| title_full | Risk factors for need of mechanical ventilation in hildren with Influenza A(H1N1)pdm09 |
| title_fullStr | Risk factors for need of mechanical ventilation in hildren with Influenza A(H1N1)pdm09 |
| title_full_unstemmed | Risk factors for need of mechanical ventilation in hildren with Influenza A(H1N1)pdm09 |
| title_short | Risk factors for need of mechanical ventilation in hildren with Influenza A(H1N1)pdm09 |
| title_sort | risk factors for need of mechanical ventilation in hildren with influenza a h1n1 pdm09 |
| topic | Influenza A H1N1 subtype Risk factors Respiratory insufficiency Child |
| url | http://www.sciencedirect.com/science/article/pii/S2255553613001043 |
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