The Use of Targeted Monoclonal Antibodies in the Treatment of ABPA—A Case Series
Allergic bronchopulmonary aspergillosis (ABPA) is a pulmonary disorder occurring in response to <i>Aspergillus fumigatus</i> that can complicate the course of asthma and cystic fibrosis. Here we present a case of acute ABPA without central bronchiectasis, a case of chronic active ABPA wi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/58/1/53 |
| _version_ | 1797492246455517184 |
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| author | Aoife O’Reilly Eleanor Dunican |
| author_facet | Aoife O’Reilly Eleanor Dunican |
| author_sort | Aoife O’Reilly |
| collection | DOAJ |
| description | Allergic bronchopulmonary aspergillosis (ABPA) is a pulmonary disorder occurring in response to <i>Aspergillus fumigatus</i> that can complicate the course of asthma and cystic fibrosis. Here we present a case of acute ABPA without central bronchiectasis, a case of chronic active ABPA with central bronchiectasis, and a case of severe relapsing ABPA with central bronchiectasis. All three were initially treated with corticosteroids and antifungal agents but had an incomplete response. These patients were then treated with anti-IgE therapy with omalizumab before being switched to the anti-IL5R agent benralizumab. They responded well to both agents. These case reports highlight the potential role of omalizumab and benralizumab in the treatment of ABPA, but further studies are required to evaluate the effectiveness of these medications. Longer follow-up periods and objective measurements of the impact of treatment are necessary. |
| first_indexed | 2024-03-10T01:00:52Z |
| format | Article |
| id | doaj.art-abefaa5779494cb59206f3155ce786f1 |
| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-10T01:00:52Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-abefaa5779494cb59206f3155ce786f12023-11-23T14:36:07ZengMDPI AGMedicina1010-660X1648-91442021-12-015815310.3390/medicina58010053The Use of Targeted Monoclonal Antibodies in the Treatment of ABPA—A Case SeriesAoife O’Reilly0Eleanor Dunican1Department of Respiratory Medicine, St. Vincent’s University Hospital, Elm Park, D04 T6F4 Dublin, IrelandDepartment of Respiratory Medicine, St. Vincent’s University Hospital, Elm Park, D04 T6F4 Dublin, IrelandAllergic bronchopulmonary aspergillosis (ABPA) is a pulmonary disorder occurring in response to <i>Aspergillus fumigatus</i> that can complicate the course of asthma and cystic fibrosis. Here we present a case of acute ABPA without central bronchiectasis, a case of chronic active ABPA with central bronchiectasis, and a case of severe relapsing ABPA with central bronchiectasis. All three were initially treated with corticosteroids and antifungal agents but had an incomplete response. These patients were then treated with anti-IgE therapy with omalizumab before being switched to the anti-IL5R agent benralizumab. They responded well to both agents. These case reports highlight the potential role of omalizumab and benralizumab in the treatment of ABPA, but further studies are required to evaluate the effectiveness of these medications. Longer follow-up periods and objective measurements of the impact of treatment are necessary.https://www.mdpi.com/1648-9144/58/1/53allergic bronchopulmonary aspergillosis (ABPA)asthma<i>Aspergillus fumigatus</i>monoclonal antibodiesimmunoglobulin E |
| spellingShingle | Aoife O’Reilly Eleanor Dunican The Use of Targeted Monoclonal Antibodies in the Treatment of ABPA—A Case Series Medicina allergic bronchopulmonary aspergillosis (ABPA) asthma <i>Aspergillus fumigatus</i> monoclonal antibodies immunoglobulin E |
| title | The Use of Targeted Monoclonal Antibodies in the Treatment of ABPA—A Case Series |
| title_full | The Use of Targeted Monoclonal Antibodies in the Treatment of ABPA—A Case Series |
| title_fullStr | The Use of Targeted Monoclonal Antibodies in the Treatment of ABPA—A Case Series |
| title_full_unstemmed | The Use of Targeted Monoclonal Antibodies in the Treatment of ABPA—A Case Series |
| title_short | The Use of Targeted Monoclonal Antibodies in the Treatment of ABPA—A Case Series |
| title_sort | use of targeted monoclonal antibodies in the treatment of abpa a case series |
| topic | allergic bronchopulmonary aspergillosis (ABPA) asthma <i>Aspergillus fumigatus</i> monoclonal antibodies immunoglobulin E |
| url | https://www.mdpi.com/1648-9144/58/1/53 |
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