Conformational analysis of Clostridium difficile toxin B and its implications for substrate recognition.

Conformational analysis of Clostridium difficile toxin B and its implications for substrate recognition.

Clostridium difficile (C. difficile) is an opportunistic pathogen that can cause potentially lethal hospital-acquired infections. The cellular damage that it causes is the result of two large clostridial cytotoxins: TcdA and TcdB which act by glucosylating cytosolic G-proteins, mis-regulation of whi...

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Bibliographic Details
Main Authors: Rebecca Swett, G Andrés Cisneros, Andrew L Feig
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22844485/?tool=EBI

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