Selective Liver Estrogen Receptor α Modulation Prevents Steatosis, Diabetes, and Obesity Through the Anorectic Growth Differentiation Factor 15 Hepatokine in Mice

Selective Liver Estrogen Receptor α Modulation Prevents Steatosis, Diabetes, and Obesity Through the Anorectic Growth Differentiation Factor 15 Hepatokine in Mice

Hepatocyte estrogen receptor α (ERα) was recently recognized as a relevant molecular target for nonalcoholic fatty liver disease (NAFLD) prevention. The present study defined to what extent hepatocyte ERα could be involved in preserving metabolic homeostasis in response to a full (17β‐estradiol [E2]...

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Main Authors: Maeva Guillaume, Elodie Riant, Aurélie Fabre, Isabelle Raymond‐Letron, Melissa Buscato, Morgane Davezac, Blandine Tramunt, Alexandra Montagner, Sarra Smati, Rana Zahreddine, Gaëlle Palierne, Marie‐Cécile Valera, Hervé Guillou, Françoise Lenfant, Klaus Unsicker, Raphaël Metivier, Coralie Fontaine, Jean‐François Arnal, Pierre Gourdy
Format: Article
Language:English
Published: Wolters Kluwer Health/LWW 2019-07-01
Series:Hepatology Communications
Online Access:https://doi.org/10.1002/hep4.1363

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