Inflammasomes in the Pathophysiology of Aortic Disease
Aortic diseases comprise aneurysms, dissections, and several other pathologies. In general, aging is associated with a slow but progressive dilation of the aorta, along with increased stiffness and pulse pressure. The progression of aortic disease is characterized by subclinical development or acute...
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| Format: | Article |
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MDPI AG
2021-09-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/10/9/2433 |
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| author | Markus Wortmann Andreas S. Peters Philipp Erhart Daniel Körfer Dittmar Böckler Susanne Dihlmann |
| author_facet | Markus Wortmann Andreas S. Peters Philipp Erhart Daniel Körfer Dittmar Böckler Susanne Dihlmann |
| author_sort | Markus Wortmann |
| collection | DOAJ |
| description | Aortic diseases comprise aneurysms, dissections, and several other pathologies. In general, aging is associated with a slow but progressive dilation of the aorta, along with increased stiffness and pulse pressure. The progression of aortic disease is characterized by subclinical development or acute presentation. Recent evidence suggests that inflammation participates causally in different clinical manifestations of aortic diseases. As of yet, diagnostic imaging and surveillance is mainly based on ultrasonography, computed tomography (CT), and magnetic resonance imaging (MRI). Little medical therapy is available so far to prevent or treat the majority of aortic diseases. Endovascular therapy by the introduction of covered stentgrafts provides the main treatment option, although open surgery and implantation of synthetic grafts remain necessary in many situations. Because of the risks associated with surgery, there is a need for identification of pharmaceutical targets interfering with the pathophysiology of aortic remodeling. The participation of innate immunity and inflammasome activation in different cell types is common in aortic diseases. This review will thus focus on inflammasome activities in vascular cells of different chronic and acute aortic diseases and discuss their role in development and progression. We will also identify research gaps and suggest promising therapeutic targets, which may be used for future medical interventions. |
| first_indexed | 2024-03-10T07:48:40Z |
| format | Article |
| id | doaj.art-abf245c486e14227b0bc186d24fdd456 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T07:48:40Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-abf245c486e14227b0bc186d24fdd4562023-11-22T12:26:06ZengMDPI AGCells2073-44092021-09-01109243310.3390/cells10092433Inflammasomes in the Pathophysiology of Aortic DiseaseMarkus Wortmann0Andreas S. Peters1Philipp Erhart2Daniel Körfer3Dittmar Böckler4Susanne Dihlmann5Department of Vascular and Endovascular Surgery, University Hospital Heidelberg, Im Neuenheimer Feld 420, 69120 Heidelberg, GermanyDepartment of Vascular and Endovascular Surgery, University Hospital Heidelberg, Im Neuenheimer Feld 420, 69120 Heidelberg, GermanyDepartment of Vascular and Endovascular Surgery, University Hospital Heidelberg, Im Neuenheimer Feld 420, 69120 Heidelberg, GermanyDepartment of Vascular and Endovascular Surgery, University Hospital Heidelberg, Im Neuenheimer Feld 420, 69120 Heidelberg, GermanyDepartment of Vascular and Endovascular Surgery, University Hospital Heidelberg, Im Neuenheimer Feld 420, 69120 Heidelberg, GermanyDepartment of Vascular and Endovascular Surgery, University Hospital Heidelberg, Im Neuenheimer Feld 420, 69120 Heidelberg, GermanyAortic diseases comprise aneurysms, dissections, and several other pathologies. In general, aging is associated with a slow but progressive dilation of the aorta, along with increased stiffness and pulse pressure. The progression of aortic disease is characterized by subclinical development or acute presentation. Recent evidence suggests that inflammation participates causally in different clinical manifestations of aortic diseases. As of yet, diagnostic imaging and surveillance is mainly based on ultrasonography, computed tomography (CT), and magnetic resonance imaging (MRI). Little medical therapy is available so far to prevent or treat the majority of aortic diseases. Endovascular therapy by the introduction of covered stentgrafts provides the main treatment option, although open surgery and implantation of synthetic grafts remain necessary in many situations. Because of the risks associated with surgery, there is a need for identification of pharmaceutical targets interfering with the pathophysiology of aortic remodeling. The participation of innate immunity and inflammasome activation in different cell types is common in aortic diseases. This review will thus focus on inflammasome activities in vascular cells of different chronic and acute aortic diseases and discuss their role in development and progression. We will also identify research gaps and suggest promising therapeutic targets, which may be used for future medical interventions.https://www.mdpi.com/2073-4409/10/9/2433aortaaneurysmdissectionaortitisPAUIMH |
| spellingShingle | Markus Wortmann Andreas S. Peters Philipp Erhart Daniel Körfer Dittmar Böckler Susanne Dihlmann Inflammasomes in the Pathophysiology of Aortic Disease Cells aorta aneurysm dissection aortitis PAU IMH |
| title | Inflammasomes in the Pathophysiology of Aortic Disease |
| title_full | Inflammasomes in the Pathophysiology of Aortic Disease |
| title_fullStr | Inflammasomes in the Pathophysiology of Aortic Disease |
| title_full_unstemmed | Inflammasomes in the Pathophysiology of Aortic Disease |
| title_short | Inflammasomes in the Pathophysiology of Aortic Disease |
| title_sort | inflammasomes in the pathophysiology of aortic disease |
| topic | aorta aneurysm dissection aortitis PAU IMH |
| url | https://www.mdpi.com/2073-4409/10/9/2433 |
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