Post-chikungunya chronic inflammatory rheumatism: results from a retrospective follow-up study of 283 adult and child cases in La Virginia, Risaralda, Colombia [version 1; referees: 2 approved]
Objective: There are limited studies in Latin America regarding the chronic consequences of the Chikungunya virus (CHIK), such as post-CHIK chronic inflammatory rheumatism (pCHIK-CIR). We assessed the largest cohort so far of pCHIK-CIR in Latin America, at the municipality of La Virginia, Risaralda,...
| Main Authors: | , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
F1000 Research Ltd
2016-03-01
|
| Series: | F1000Research |
| Subjects: | |
| Online Access: | http://f1000research.com/articles/5-360/v1 |
| _version_ | 1811289183290916864 |
|---|---|
| author | Alfonso J. Rodriguez-Morales Andrés F. Gil-Restrepo Valeria Ramírez-Jaramillo Cindy P. Montoya-Arias Wilmer F. Acevedo-Mendoza Juan E. Bedoya-Arias Laura A. Chica-Quintero David R. Murillo-García Juan E. García-Robledo Juan D. Castrillón-Spitia Jose J. Londoño Hector D. Bedoya-Rendón Javier de Jesús Cárdenas-Pérez Jaime A. Cardona-Ospina Guillermo J. Lagos-Grisales |
| author_facet | Alfonso J. Rodriguez-Morales Andrés F. Gil-Restrepo Valeria Ramírez-Jaramillo Cindy P. Montoya-Arias Wilmer F. Acevedo-Mendoza Juan E. Bedoya-Arias Laura A. Chica-Quintero David R. Murillo-García Juan E. García-Robledo Juan D. Castrillón-Spitia Jose J. Londoño Hector D. Bedoya-Rendón Javier de Jesús Cárdenas-Pérez Jaime A. Cardona-Ospina Guillermo J. Lagos-Grisales |
| author_sort | Alfonso J. Rodriguez-Morales |
| collection | DOAJ |
| description | Objective: There are limited studies in Latin America regarding the chronic consequences of the Chikungunya virus (CHIK), such as post-CHIK chronic inflammatory rheumatism (pCHIK-CIR). We assessed the largest cohort so far of pCHIK-CIR in Latin America, at the municipality of La Virginia, Risaralda, a new endemic area of CHIK in Colombia. Methods: We conducted a cohort retrospective study in Colombia of 283 patients diagnosed with CHIK that persisted with pCHIK-CIR after a minimum of 6 weeks and up to a maximum of 26.1 weeks. pCHIK cases were identified according to validated criteria via telephone. Results: Of the total CHIK-infected subjects, 152 (53.7%) reported persistent rheumatological symptoms (pCHIK-CIR). All of these patients reported joint pains (chronic polyarthralgia, pCHIK-CPA), 49.5% morning stiffness, 40.6% joint edema, and 16.6% joint redness. Of all patients, 19.4% required and attended for care prior to the current study assessment (1.4% consulting rheumatologists). Significant differences in the frequency were observed according to age groups and gender. Patients aged >40 years old required more medical attention (39.5%) than those ≤40 years-old (12.1%) (RR=4.748, 95%CI 2.550-8.840). Conclusions: According to our results, at least half of the patients with CHIK developed chronic rheumatologic sequelae, and from those with pCHIK-CPA, nearly half presented clinical symptoms consistent with inflammatory forms of the disease. These results support previous estimates obtained from pooled data of studies in La Reunion (France) and India and are consistent with the results published previously from other Colombian cohorts in Venadillo (Tolima) and Since (Sucre). |
| first_indexed | 2024-04-13T03:50:23Z |
| format | Article |
| id | doaj.art-abf3263550dc4617816e56200888c705 |
| institution | Directory Open Access Journal |
| issn | 2046-1402 |
| language | English |
| last_indexed | 2024-04-13T03:50:23Z |
| publishDate | 2016-03-01 |
| publisher | F1000 Research Ltd |
| record_format | Article |
| series | F1000Research |
| spelling | doaj.art-abf3263550dc4617816e56200888c7052022-12-22T03:03:50ZengF1000 Research LtdF1000Research2046-14022016-03-01510.12688/f1000research.8235.18857Post-chikungunya chronic inflammatory rheumatism: results from a retrospective follow-up study of 283 adult and child cases in La Virginia, Risaralda, Colombia [version 1; referees: 2 approved]Alfonso J. Rodriguez-Morales0Andrés F. Gil-Restrepo1Valeria Ramírez-Jaramillo2Cindy P. Montoya-Arias3Wilmer F. Acevedo-Mendoza4Juan E. Bedoya-Arias5Laura A. Chica-Quintero6David R. Murillo-García7Juan E. García-Robledo8Juan D. Castrillón-Spitia9Jose J. Londoño10Hector D. Bedoya-Rendón11Javier de Jesús Cárdenas-Pérez12Jaime A. Cardona-Ospina13Guillermo J. Lagos-Grisales14Working Group on Zoonoses, International Society for Chemotherapy, Aberdeen, UKPublic Health and Infection Research Group, Faculty of Health Sciences,, Universidad Tecnológica de Pereira, Pereira, ColombiaPublic Health and Infection Research Group, Faculty of Health Sciences,, Universidad Tecnológica de Pereira, Pereira, ColombiaPublic Health and Infection Research Group, Faculty of Health Sciences,, Universidad Tecnológica de Pereira, Pereira, ColombiaPublic Health and Infection Research Group, Faculty of Health Sciences,, Universidad Tecnológica de Pereira, Pereira, ColombiaPublic Health and Infection Research Group, Faculty of Health Sciences,, Universidad Tecnológica de Pereira, Pereira, ColombiaPublic Health and Infection Research Group, Faculty of Health Sciences,, Universidad Tecnológica de Pereira, Pereira, ColombiaPublic Health and Infection Research Group, Faculty of Health Sciences,, Universidad Tecnológica de Pereira, Pereira, ColombiaSchool of Medicine, Faculty of Health Sciences, Universidad ICESI, Cali, ColombiaESE Hospital San Pedro y San Pablo, La Virginia, ColombiaSchool of Medicine, Faculty of Health Sciences, Universidad ICESI, Cali, ColombiaESE Hospital San Pedro y San Pablo, La Virginia, ColombiaESE Hospital San Pedro y San Pablo, La Virginia, ColombiaPublic Health and Infection Research Group, Faculty of Health Sciences,, Universidad Tecnológica de Pereira, Pereira, ColombiaPublic Health and Infection Research Group, Faculty of Health Sciences,, Universidad Tecnológica de Pereira, Pereira, ColombiaObjective: There are limited studies in Latin America regarding the chronic consequences of the Chikungunya virus (CHIK), such as post-CHIK chronic inflammatory rheumatism (pCHIK-CIR). We assessed the largest cohort so far of pCHIK-CIR in Latin America, at the municipality of La Virginia, Risaralda, a new endemic area of CHIK in Colombia. Methods: We conducted a cohort retrospective study in Colombia of 283 patients diagnosed with CHIK that persisted with pCHIK-CIR after a minimum of 6 weeks and up to a maximum of 26.1 weeks. pCHIK cases were identified according to validated criteria via telephone. Results: Of the total CHIK-infected subjects, 152 (53.7%) reported persistent rheumatological symptoms (pCHIK-CIR). All of these patients reported joint pains (chronic polyarthralgia, pCHIK-CPA), 49.5% morning stiffness, 40.6% joint edema, and 16.6% joint redness. Of all patients, 19.4% required and attended for care prior to the current study assessment (1.4% consulting rheumatologists). Significant differences in the frequency were observed according to age groups and gender. Patients aged >40 years old required more medical attention (39.5%) than those ≤40 years-old (12.1%) (RR=4.748, 95%CI 2.550-8.840). Conclusions: According to our results, at least half of the patients with CHIK developed chronic rheumatologic sequelae, and from those with pCHIK-CPA, nearly half presented clinical symptoms consistent with inflammatory forms of the disease. These results support previous estimates obtained from pooled data of studies in La Reunion (France) and India and are consistent with the results published previously from other Colombian cohorts in Venadillo (Tolima) and Since (Sucre).http://f1000research.com/articles/5-360/v1Tropical & Travel-Associated Diseases |
| spellingShingle | Alfonso J. Rodriguez-Morales Andrés F. Gil-Restrepo Valeria Ramírez-Jaramillo Cindy P. Montoya-Arias Wilmer F. Acevedo-Mendoza Juan E. Bedoya-Arias Laura A. Chica-Quintero David R. Murillo-García Juan E. García-Robledo Juan D. Castrillón-Spitia Jose J. Londoño Hector D. Bedoya-Rendón Javier de Jesús Cárdenas-Pérez Jaime A. Cardona-Ospina Guillermo J. Lagos-Grisales Post-chikungunya chronic inflammatory rheumatism: results from a retrospective follow-up study of 283 adult and child cases in La Virginia, Risaralda, Colombia [version 1; referees: 2 approved] F1000Research Tropical & Travel-Associated Diseases |
| title | Post-chikungunya chronic inflammatory rheumatism: results from a retrospective follow-up study of 283 adult and child cases in La Virginia, Risaralda, Colombia [version 1; referees: 2 approved] |
| title_full | Post-chikungunya chronic inflammatory rheumatism: results from a retrospective follow-up study of 283 adult and child cases in La Virginia, Risaralda, Colombia [version 1; referees: 2 approved] |
| title_fullStr | Post-chikungunya chronic inflammatory rheumatism: results from a retrospective follow-up study of 283 adult and child cases in La Virginia, Risaralda, Colombia [version 1; referees: 2 approved] |
| title_full_unstemmed | Post-chikungunya chronic inflammatory rheumatism: results from a retrospective follow-up study of 283 adult and child cases in La Virginia, Risaralda, Colombia [version 1; referees: 2 approved] |
| title_short | Post-chikungunya chronic inflammatory rheumatism: results from a retrospective follow-up study of 283 adult and child cases in La Virginia, Risaralda, Colombia [version 1; referees: 2 approved] |
| title_sort | post chikungunya chronic inflammatory rheumatism results from a retrospective follow up study of 283 adult and child cases in la virginia risaralda colombia version 1 referees 2 approved |
| topic | Tropical & Travel-Associated Diseases |
| url | http://f1000research.com/articles/5-360/v1 |
| work_keys_str_mv | AT alfonsojrodriguezmorales postchikungunyachronicinflammatoryrheumatismresultsfromaretrospectivefollowupstudyof283adultandchildcasesinlavirginiarisaraldacolombiaversion1referees2approved AT andresfgilrestrepo postchikungunyachronicinflammatoryrheumatismresultsfromaretrospectivefollowupstudyof283adultandchildcasesinlavirginiarisaraldacolombiaversion1referees2approved AT valeriaramirezjaramillo postchikungunyachronicinflammatoryrheumatismresultsfromaretrospectivefollowupstudyof283adultandchildcasesinlavirginiarisaraldacolombiaversion1referees2approved AT cindypmontoyaarias postchikungunyachronicinflammatoryrheumatismresultsfromaretrospectivefollowupstudyof283adultandchildcasesinlavirginiarisaraldacolombiaversion1referees2approved AT wilmerfacevedomendoza postchikungunyachronicinflammatoryrheumatismresultsfromaretrospectivefollowupstudyof283adultandchildcasesinlavirginiarisaraldacolombiaversion1referees2approved AT juanebedoyaarias postchikungunyachronicinflammatoryrheumatismresultsfromaretrospectivefollowupstudyof283adultandchildcasesinlavirginiarisaraldacolombiaversion1referees2approved AT lauraachicaquintero postchikungunyachronicinflammatoryrheumatismresultsfromaretrospectivefollowupstudyof283adultandchildcasesinlavirginiarisaraldacolombiaversion1referees2approved AT davidrmurillogarcia postchikungunyachronicinflammatoryrheumatismresultsfromaretrospectivefollowupstudyof283adultandchildcasesinlavirginiarisaraldacolombiaversion1referees2approved AT juanegarciarobledo postchikungunyachronicinflammatoryrheumatismresultsfromaretrospectivefollowupstudyof283adultandchildcasesinlavirginiarisaraldacolombiaversion1referees2approved AT juandcastrillonspitia postchikungunyachronicinflammatoryrheumatismresultsfromaretrospectivefollowupstudyof283adultandchildcasesinlavirginiarisaraldacolombiaversion1referees2approved AT josejlondono postchikungunyachronicinflammatoryrheumatismresultsfromaretrospectivefollowupstudyof283adultandchildcasesinlavirginiarisaraldacolombiaversion1referees2approved AT hectordbedoyarendon postchikungunyachronicinflammatoryrheumatismresultsfromaretrospectivefollowupstudyof283adultandchildcasesinlavirginiarisaraldacolombiaversion1referees2approved AT javierdejesuscardenasperez postchikungunyachronicinflammatoryrheumatismresultsfromaretrospectivefollowupstudyof283adultandchildcasesinlavirginiarisaraldacolombiaversion1referees2approved AT jaimeacardonaospina postchikungunyachronicinflammatoryrheumatismresultsfromaretrospectivefollowupstudyof283adultandchildcasesinlavirginiarisaraldacolombiaversion1referees2approved AT guillermojlagosgrisales postchikungunyachronicinflammatoryrheumatismresultsfromaretrospectivefollowupstudyof283adultandchildcasesinlavirginiarisaraldacolombiaversion1referees2approved |