A rational blueprint for the design of chemically-controlled protein switches
Small-molecule responsive protein switches are crucial components to control synthetic cellular activities. Here, we present a computational protein design strategy to repurpose drug-inhibited protein-protein interactions into OFF- and ON-switches active in cells.
Bibliographic Details
| Main Authors: |
Sailan Shui,
Pablo Gainza,
Leo Scheller,
Che Yang,
Yoichi Kurumida,
Stéphane Rosset,
Sandrine Georgeon,
Raphaël B. Di Roberto,
Rocío Castellanos-Rueda,
Sai T. Reddy,
Bruno E. Correia |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2021-10-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-021-25735-9
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