A rational blueprint for the design of chemically-controlled protein switches
Small-molecule responsive protein switches are crucial components to control synthetic cellular activities. Here, we present a computational protein design strategy to repurpose drug-inhibited protein-protein interactions into OFF- and ON-switches active in cells.
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-10-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-25735-9 |
| _version_ | 1818718926335377408 |
|---|---|
| author | Sailan Shui Pablo Gainza Leo Scheller Che Yang Yoichi Kurumida Stéphane Rosset Sandrine Georgeon Raphaël B. Di Roberto Rocío Castellanos-Rueda Sai T. Reddy Bruno E. Correia |
| author_facet | Sailan Shui Pablo Gainza Leo Scheller Che Yang Yoichi Kurumida Stéphane Rosset Sandrine Georgeon Raphaël B. Di Roberto Rocío Castellanos-Rueda Sai T. Reddy Bruno E. Correia |
| author_sort | Sailan Shui |
| collection | DOAJ |
| description | Small-molecule responsive protein switches are crucial components to control synthetic cellular activities. Here, we present a computational protein design strategy to repurpose drug-inhibited protein-protein interactions into OFF- and ON-switches active in cells. |
| first_indexed | 2024-12-17T19:58:48Z |
| format | Article |
| id | doaj.art-abf45e9fa38440d9ad04bb724c9f71ce |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-17T19:58:48Z |
| publishDate | 2021-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-abf45e9fa38440d9ad04bb724c9f71ce2022-12-21T21:34:32ZengNature PortfolioNature Communications2041-17232021-10-0112111210.1038/s41467-021-25735-9A rational blueprint for the design of chemically-controlled protein switchesSailan Shui0Pablo Gainza1Leo Scheller2Che Yang3Yoichi Kurumida4Stéphane Rosset5Sandrine Georgeon6Raphaël B. Di Roberto7Rocío Castellanos-Rueda8Sai T. Reddy9Bruno E. Correia10Laboratory of Protein Design and Immunoengineering (LPDI) - STI - EPFLLaboratory of Protein Design and Immunoengineering (LPDI) - STI - EPFLLaboratory of Protein Design and Immunoengineering (LPDI) - STI - EPFLLaboratory of Protein Design and Immunoengineering (LPDI) - STI - EPFLDepartment of Life Science, School and Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Meguro-kuLaboratory of Protein Design and Immunoengineering (LPDI) - STI - EPFLLaboratory of Protein Design and Immunoengineering (LPDI) - STI - EPFLDepartment of Biosystems Science and Engineering, ETH ZürichDepartment of Biosystems Science and Engineering, ETH ZürichDepartment of Biosystems Science and Engineering, ETH ZürichLaboratory of Protein Design and Immunoengineering (LPDI) - STI - EPFLSmall-molecule responsive protein switches are crucial components to control synthetic cellular activities. Here, we present a computational protein design strategy to repurpose drug-inhibited protein-protein interactions into OFF- and ON-switches active in cells.https://doi.org/10.1038/s41467-021-25735-9 |
| spellingShingle | Sailan Shui Pablo Gainza Leo Scheller Che Yang Yoichi Kurumida Stéphane Rosset Sandrine Georgeon Raphaël B. Di Roberto Rocío Castellanos-Rueda Sai T. Reddy Bruno E. Correia A rational blueprint for the design of chemically-controlled protein switches Nature Communications |
| title | A rational blueprint for the design of chemically-controlled protein switches |
| title_full | A rational blueprint for the design of chemically-controlled protein switches |
| title_fullStr | A rational blueprint for the design of chemically-controlled protein switches |
| title_full_unstemmed | A rational blueprint for the design of chemically-controlled protein switches |
| title_short | A rational blueprint for the design of chemically-controlled protein switches |
| title_sort | rational blueprint for the design of chemically controlled protein switches |
| url | https://doi.org/10.1038/s41467-021-25735-9 |
| work_keys_str_mv | AT sailanshui arationalblueprintforthedesignofchemicallycontrolledproteinswitches AT pablogainza arationalblueprintforthedesignofchemicallycontrolledproteinswitches AT leoscheller arationalblueprintforthedesignofchemicallycontrolledproteinswitches AT cheyang arationalblueprintforthedesignofchemicallycontrolledproteinswitches AT yoichikurumida arationalblueprintforthedesignofchemicallycontrolledproteinswitches AT stephanerosset arationalblueprintforthedesignofchemicallycontrolledproteinswitches AT sandrinegeorgeon arationalblueprintforthedesignofchemicallycontrolledproteinswitches AT raphaelbdiroberto arationalblueprintforthedesignofchemicallycontrolledproteinswitches AT rociocastellanosrueda arationalblueprintforthedesignofchemicallycontrolledproteinswitches AT saitreddy arationalblueprintforthedesignofchemicallycontrolledproteinswitches AT brunoecorreia arationalblueprintforthedesignofchemicallycontrolledproteinswitches AT sailanshui rationalblueprintforthedesignofchemicallycontrolledproteinswitches AT pablogainza rationalblueprintforthedesignofchemicallycontrolledproteinswitches AT leoscheller rationalblueprintforthedesignofchemicallycontrolledproteinswitches AT cheyang rationalblueprintforthedesignofchemicallycontrolledproteinswitches AT yoichikurumida rationalblueprintforthedesignofchemicallycontrolledproteinswitches AT stephanerosset rationalblueprintforthedesignofchemicallycontrolledproteinswitches AT sandrinegeorgeon rationalblueprintforthedesignofchemicallycontrolledproteinswitches AT raphaelbdiroberto rationalblueprintforthedesignofchemicallycontrolledproteinswitches AT rociocastellanosrueda rationalblueprintforthedesignofchemicallycontrolledproteinswitches AT saitreddy rationalblueprintforthedesignofchemicallycontrolledproteinswitches AT brunoecorreia rationalblueprintforthedesignofchemicallycontrolledproteinswitches |