Survival and predictors of death in people with HIV-associated lymphoma compared to those with a diagnosis of lymphoma in general population.
to compare overall survival in HIV-associated lymphoma (HIV-L) and lymphoma raising in HIV-negative population (nHIV-L) and to identify predictors of increased risk of death.All HIV+ patients with HIV-associated lymphoma (Hodgkin lymphoma, HL; non-Hodgkin Lymphoma, NHL) observed between 1.2000 and 1...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2017-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5663375?pdf=render |
| _version_ | 1819065524331479040 |
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| author | Antonella Cingolani Alessandro Cozzi Lepri Luciana Teofili Laura Galli Valentina Mazzotta Gian Maria Baldin Stefan Hohaus Alessandra Bandera Lucia Alba Nadia Galizzi Antonella Castagna Antonella D'arminio Monforte Andrea Antinori ICONA Foundation Study group |
| author_facet | Antonella Cingolani Alessandro Cozzi Lepri Luciana Teofili Laura Galli Valentina Mazzotta Gian Maria Baldin Stefan Hohaus Alessandra Bandera Lucia Alba Nadia Galizzi Antonella Castagna Antonella D'arminio Monforte Andrea Antinori ICONA Foundation Study group |
| author_sort | Antonella Cingolani |
| collection | DOAJ |
| description | to compare overall survival in HIV-associated lymphoma (HIV-L) and lymphoma raising in HIV-negative population (nHIV-L) and to identify predictors of increased risk of death.All HIV+ patients with HIV-associated lymphoma (Hodgkin lymphoma, HL; non-Hodgkin Lymphoma, NHL) observed between 1.2000 and 12.2013 in the ICONA Foundation Study cohort or in three collaborating centres, and, as control group, nHIV-L individuals followed in one of the four collaborating centres over the same time period, were included. Survival estimates were calculated by use of Kaplan-Meier (KM) and multivariable Cox regression models.1,331 pts were included (465 HIV-L, 866 nHIV-L): 909 (68%) NHL, 422 (32%) HL. 3 years-cumulative probability (95% confidence interval, CI) of death was higher in HIV-L compared to nHIV-L in NHL (38% (33-44) vs. 22% (19-26); p<0.001), and HL (22% [15-29] vs. 10% (6-13), p<0.001). Among HL, HIV was associated with an increased risk of death (hazard ratio [HR] = 2.37 [95% CI: 1.24-4.55], p = 0.009) independently of calendar year, age, gender, type of chemotherapy and stage; in NHL, HIV was no longer an independent predictor of death after controlling for rituximab use and IPI (HR = 1.26 (0.97-1.63), p = 0.08).Our analysis shows a reduced overall survival in HIV+ patients diagnosed with lymphoma compared to HIV-negative controls. Whereas in HIV people with HL, the increased risk of death was confirmed even after adjustment for main confounders, the association between HIV status and survival in NHL appears to be somewhat attenuated after controlling for more aggressive presentation and lower frequency of rituximab use in HIV-+ people. |
| first_indexed | 2024-12-21T15:47:50Z |
| format | Article |
| id | doaj.art-abf45ea9597b4c47b2cc7b9c7f94deb5 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-21T15:47:50Z |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-abf45ea9597b4c47b2cc7b9c7f94deb52022-12-21T18:58:19ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-011210e018654910.1371/journal.pone.0186549Survival and predictors of death in people with HIV-associated lymphoma compared to those with a diagnosis of lymphoma in general population.Antonella CingolaniAlessandro Cozzi LepriLuciana TeofiliLaura GalliValentina MazzottaGian Maria BaldinStefan HohausAlessandra BanderaLucia AlbaNadia GalizziAntonella CastagnaAntonella D'arminio MonforteAndrea AntinoriICONA Foundation Study groupto compare overall survival in HIV-associated lymphoma (HIV-L) and lymphoma raising in HIV-negative population (nHIV-L) and to identify predictors of increased risk of death.All HIV+ patients with HIV-associated lymphoma (Hodgkin lymphoma, HL; non-Hodgkin Lymphoma, NHL) observed between 1.2000 and 12.2013 in the ICONA Foundation Study cohort or in three collaborating centres, and, as control group, nHIV-L individuals followed in one of the four collaborating centres over the same time period, were included. Survival estimates were calculated by use of Kaplan-Meier (KM) and multivariable Cox regression models.1,331 pts were included (465 HIV-L, 866 nHIV-L): 909 (68%) NHL, 422 (32%) HL. 3 years-cumulative probability (95% confidence interval, CI) of death was higher in HIV-L compared to nHIV-L in NHL (38% (33-44) vs. 22% (19-26); p<0.001), and HL (22% [15-29] vs. 10% (6-13), p<0.001). Among HL, HIV was associated with an increased risk of death (hazard ratio [HR] = 2.37 [95% CI: 1.24-4.55], p = 0.009) independently of calendar year, age, gender, type of chemotherapy and stage; in NHL, HIV was no longer an independent predictor of death after controlling for rituximab use and IPI (HR = 1.26 (0.97-1.63), p = 0.08).Our analysis shows a reduced overall survival in HIV+ patients diagnosed with lymphoma compared to HIV-negative controls. Whereas in HIV people with HL, the increased risk of death was confirmed even after adjustment for main confounders, the association between HIV status and survival in NHL appears to be somewhat attenuated after controlling for more aggressive presentation and lower frequency of rituximab use in HIV-+ people.http://europepmc.org/articles/PMC5663375?pdf=render |
| spellingShingle | Antonella Cingolani Alessandro Cozzi Lepri Luciana Teofili Laura Galli Valentina Mazzotta Gian Maria Baldin Stefan Hohaus Alessandra Bandera Lucia Alba Nadia Galizzi Antonella Castagna Antonella D'arminio Monforte Andrea Antinori ICONA Foundation Study group Survival and predictors of death in people with HIV-associated lymphoma compared to those with a diagnosis of lymphoma in general population. PLoS ONE |
| title | Survival and predictors of death in people with HIV-associated lymphoma compared to those with a diagnosis of lymphoma in general population. |
| title_full | Survival and predictors of death in people with HIV-associated lymphoma compared to those with a diagnosis of lymphoma in general population. |
| title_fullStr | Survival and predictors of death in people with HIV-associated lymphoma compared to those with a diagnosis of lymphoma in general population. |
| title_full_unstemmed | Survival and predictors of death in people with HIV-associated lymphoma compared to those with a diagnosis of lymphoma in general population. |
| title_short | Survival and predictors of death in people with HIV-associated lymphoma compared to those with a diagnosis of lymphoma in general population. |
| title_sort | survival and predictors of death in people with hiv associated lymphoma compared to those with a diagnosis of lymphoma in general population |
| url | http://europepmc.org/articles/PMC5663375?pdf=render |
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