High‐Performance Multi‐Dynamic Bond Cross‐Linked Hydrogel with Spatiotemporal siRNA Delivery for Gene–Cell Combination Therapy of Intervertebral Disc Degeneration

High‐Performance Multi‐Dynamic Bond Cross‐Linked Hydrogel with Spatiotemporal siRNA Delivery for Gene–Cell Combination Therapy of Intervertebral Disc Degeneration

Abstract Chronic inflammatory diseases, such as intervertebral disc degeneration (IVDD), which affect the lives of hundreds of millions of people, still lack effective and precise treatments. In this study, a novel hydrogel system with many extraordinary properties is developed for gene–cell combina...

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Bibliographic Details
Main Authors: Jiaxin Chen, Haifeng Zhu, Jiechao Xia, Yutao Zhu, Chen Xia, Zehui Hu, Yang Jin, Ji Wang, Yong He, Jiayong Dai, Zhijun Hu
Format: Article
Language:English
Published: Wiley 2023-06-01
Series:Advanced Science
Subjects:
anti‐inflammatory
gene silencing
multi‐dynamic bonds
multifunctional hydrogels
tissue regeneration
Online Access:https://doi.org/10.1002/advs.202206306

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