COVID-19: How Effective Are the Repurposed Drugs and Novel Agents in Treating the Infection?
Abstract Coronavirus disease 2019 (COVID-19) induced by the severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) has impacted the lives and wellbeing of many people. This globally widespread disease poses a significant public health concern that urges to discover an effective treatment....
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Knowledge E
2022-12-01
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| Series: | Sudan Journal of Medical Sciences |
| Subjects: | |
| Online Access: | https://doi.org/10.18502/sjms.v17i4.12550 |
| _version_ | 1828070547368443904 |
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| author | Chow Suet-May Kuok Sin-Yee Lee Jia-Qing Goh Pey-Wen Harleen Kaur A/P Ranjit Singh Timothy Tan Zhi-Zheng Jhi-Biau Foo Sharina Hamzah Renukha Sellappans Yow Hui-Yin1comma2comma3* |
| author_facet | Chow Suet-May Kuok Sin-Yee Lee Jia-Qing Goh Pey-Wen Harleen Kaur A/P Ranjit Singh Timothy Tan Zhi-Zheng Jhi-Biau Foo Sharina Hamzah Renukha Sellappans Yow Hui-Yin1comma2comma3* |
| author_sort | Chow Suet-May |
| collection | DOAJ |
| description | Abstract Coronavirus disease 2019 (COVID-19) induced by the severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) has impacted the lives and wellbeing of many people. This globally widespread disease poses a significant public health concern that urges to discover an effective treatment. This review paper discusses the effectiveness of repurposed drugs used to treat COVID-19 and potential novel therapies for COVID-19. Among the various repurposed drugs, remdesivir is the only agent approved by the Food and Drug Administration (FDA) to treat COVID-19. On the other hand, several drugs have been listed in the Emergency Use Authorization (EUA) by the FDA to treat COVID-19, including casirivimab and imdevimab, baricitinib (in combination with remdesivir), bamlanivimab, tocilizumab, and IL-6 inhibitors. In addition, in vitro and clinical studies have suggested cepharanthine, sotrovimab, and XAV-19 as potential treatments to manage COVID-19. Due to inadequate understanding of COVID-19 and the rapid mutation of SARS-CoV-2, COVID-19 remains a threat to global public health, with vaccination considered the most effective method to decrease COVID-19 transmission currently. Nevertheless, with the intense efforts of clinical researchers globally, more promising treatments for COVID-19 will be established in the future. |
| first_indexed | 2024-04-11T00:39:27Z |
| format | Article |
| id | doaj.art-abf4e2709d994d76bbb80863b9f64b54 |
| institution | Directory Open Access Journal |
| issn | 1858-5051 |
| language | English |
| last_indexed | 2024-04-11T00:39:27Z |
| publishDate | 2022-12-01 |
| publisher | Knowledge E |
| record_format | Article |
| series | Sudan Journal of Medical Sciences |
| spelling | doaj.art-abf4e2709d994d76bbb80863b9f64b542023-01-06T10:23:13ZengKnowledge ESudan Journal of Medical Sciences1858-50512022-12-0117449853810.18502/sjms.v17i4.12550sjms.v17i4.12550COVID-19: How Effective Are the Repurposed Drugs and Novel Agents in Treating the Infection?Chow Suet-May0Kuok Sin-Yee1Lee Jia-Qing2Goh Pey-Wen3Harleen Kaur A/P Ranjit Singh4Timothy Tan Zhi-Zheng5Jhi-Biau Foo6Sharina Hamzah7Renukha Sellappans8Yow Hui-Yin1comma2comma3* School of Pharmacy, Faculty of Health and Medical Sciences, Taylor's University, Subang Jaya, Malaysia School of Pharmacy, Faculty of Health and Medical Sciences, Taylor's University, Subang Jaya, Malaysia School of Pharmacy, Faculty of Health and Medical Sciences, Taylor's University, Subang Jaya, Malaysia School of Pharmacy, Faculty of Health and Medical Sciences, Taylor's University, Subang Jaya, Malaysia School of Pharmacy, Faculty of Health and Medical Sciences, Taylor's University, Subang Jaya, Malaysia School of Pharmacy, Faculty of Health and Medical Sciences, Taylor's University, Subang Jaya, Malaysia School of Pharmacy, Faculty of Health and Medical Sciences, Taylor's University, Subang Jaya, Malaysia School of Pharmacy, Faculty of Health and Medical Sciences, Taylor's University, Subang Jaya, Malaysia School of Pharmacy, Faculty of Health and Medical Sciences, Taylor's University, Subang Jaya, MalaysiaAbstract Coronavirus disease 2019 (COVID-19) induced by the severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) has impacted the lives and wellbeing of many people. This globally widespread disease poses a significant public health concern that urges to discover an effective treatment. This review paper discusses the effectiveness of repurposed drugs used to treat COVID-19 and potential novel therapies for COVID-19. Among the various repurposed drugs, remdesivir is the only agent approved by the Food and Drug Administration (FDA) to treat COVID-19. On the other hand, several drugs have been listed in the Emergency Use Authorization (EUA) by the FDA to treat COVID-19, including casirivimab and imdevimab, baricitinib (in combination with remdesivir), bamlanivimab, tocilizumab, and IL-6 inhibitors. In addition, in vitro and clinical studies have suggested cepharanthine, sotrovimab, and XAV-19 as potential treatments to manage COVID-19. Due to inadequate understanding of COVID-19 and the rapid mutation of SARS-CoV-2, COVID-19 remains a threat to global public health, with vaccination considered the most effective method to decrease COVID-19 transmission currently. Nevertheless, with the intense efforts of clinical researchers globally, more promising treatments for COVID-19 will be established in the future.https://doi.org/10.18502/sjms.v17i4.12550covid-19, sars-cov-2, treatment, drug repurposing, antiviral agents |
| spellingShingle | Chow Suet-May Kuok Sin-Yee Lee Jia-Qing Goh Pey-Wen Harleen Kaur A/P Ranjit Singh Timothy Tan Zhi-Zheng Jhi-Biau Foo Sharina Hamzah Renukha Sellappans Yow Hui-Yin1comma2comma3* COVID-19: How Effective Are the Repurposed Drugs and Novel Agents in Treating the Infection? Sudan Journal of Medical Sciences covid-19, sars-cov-2, treatment, drug repurposing, antiviral agents |
| title | COVID-19: How Effective Are the Repurposed Drugs and Novel Agents in Treating the Infection? |
| title_full | COVID-19: How Effective Are the Repurposed Drugs and Novel Agents in Treating the Infection? |
| title_fullStr | COVID-19: How Effective Are the Repurposed Drugs and Novel Agents in Treating the Infection? |
| title_full_unstemmed | COVID-19: How Effective Are the Repurposed Drugs and Novel Agents in Treating the Infection? |
| title_short | COVID-19: How Effective Are the Repurposed Drugs and Novel Agents in Treating the Infection? |
| title_sort | covid 19 how effective are the repurposed drugs and novel agents in treating the infection |
| topic | covid-19, sars-cov-2, treatment, drug repurposing, antiviral agents |
| url | https://doi.org/10.18502/sjms.v17i4.12550 |
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