Interferon-stimulated gene PVRL4 broadly suppresses viral entry by inhibiting viral-cellular membrane fusion

Interferon-stimulated gene PVRL4 broadly suppresses viral entry by inhibiting viral-cellular membrane fusion

Abstract Background Viral infection elicits the type I interferon (IFN-I) response in host cells and subsequently inhibits viral infection through inducing hundreds of IFN-stimulated genes (ISGs) that counteract many steps in the virus life cycle. However, most of ISGs have unclear functions and mec...

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Bibliographic Details
Main Authors: Qiaomei Cai, Nina Sun, Yurui Zhang, Jingfeng Wang, Chaohu Pan, Yu Chen, Lili Li, Xiaorong Li, Wancheng Liu, Saba R. Aliyari, Heng Yang, Genhong Cheng
Format: Article
Language:English
Published: BMC 2024-02-01
Series:Cell & Bioscience
Subjects:
IFN-I
PVRL4
Viral entry
Membrane fusion
Online Access:https://doi.org/10.1186/s13578-024-01202-y

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