Puerarin: A protective drug against ischemia-reperfusion injury
Ischemia-reperfusion (I/R) is a pathological process that occurs in numerous organs throughout the human body and is frequently associated with severe cellular damage and death. Puerarin is an isoflavone compound extracted from the root of Pueraria lobata and has pharmacological effects such as dila...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.927611/full |
| _version_ | 1817999573727051776 |
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| author | Minglang Gao Ziyao Zhang Kai Lai Yu Deng Chuanbing Zhao Zilong Lu Qing Geng |
| author_facet | Minglang Gao Ziyao Zhang Kai Lai Yu Deng Chuanbing Zhao Zilong Lu Qing Geng |
| author_sort | Minglang Gao |
| collection | DOAJ |
| description | Ischemia-reperfusion (I/R) is a pathological process that occurs in numerous organs throughout the human body and is frequently associated with severe cellular damage and death. Puerarin is an isoflavone compound extracted from the root of Pueraria lobata and has pharmacological effects such as dilating cerebral vessels and anti-free radical generation in cerebral ischemic tissues. With the deepening of experimental research and clinical research on puerarin, it has been found that puerarin has a protective effect on ischemia-reperfusion injury (IRI) of the heart, brain, spinal cord, lung, intestine and other organs. In summary, puerarin has a vast range of pharmacological effects and significant protective effects, and it also has obvious advantages in the clinical protection of patients with organ IRI. With the deepening of experimental pharmacological research and clinical research, it is expected to be an effective drug for IRI treatment. In this review, we summarize the current knowledge of the protective effect of puerarin on I/R organ injury and its possible underlying molecular mechanisms. |
| first_indexed | 2024-04-14T03:10:44Z |
| format | Article |
| id | doaj.art-abf5d5e8b6b7455d88b782828915cc37 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-14T03:10:44Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-abf5d5e8b6b7455d88b782828915cc372022-12-22T02:15:36ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-08-011310.3389/fphar.2022.927611927611Puerarin: A protective drug against ischemia-reperfusion injuryMinglang Gao0Ziyao Zhang1Kai Lai2Yu Deng3Chuanbing Zhao4Zilong Lu5Qing Geng6Department of Thoracic Surgery, Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of Thoracic Surgery, Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of Thoracic Surgery, Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of Thoracic Surgery, Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of Pancreatic Surgery, Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of Thoracic Surgery, Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of Thoracic Surgery, Renmin Hospital of Wuhan University, Wuhan, ChinaIschemia-reperfusion (I/R) is a pathological process that occurs in numerous organs throughout the human body and is frequently associated with severe cellular damage and death. Puerarin is an isoflavone compound extracted from the root of Pueraria lobata and has pharmacological effects such as dilating cerebral vessels and anti-free radical generation in cerebral ischemic tissues. With the deepening of experimental research and clinical research on puerarin, it has been found that puerarin has a protective effect on ischemia-reperfusion injury (IRI) of the heart, brain, spinal cord, lung, intestine and other organs. In summary, puerarin has a vast range of pharmacological effects and significant protective effects, and it also has obvious advantages in the clinical protection of patients with organ IRI. With the deepening of experimental pharmacological research and clinical research, it is expected to be an effective drug for IRI treatment. In this review, we summarize the current knowledge of the protective effect of puerarin on I/R organ injury and its possible underlying molecular mechanisms.https://www.frontiersin.org/articles/10.3389/fphar.2022.927611/fullpuerarinischemia-reperfusion injury (I/R)myocardiumbrainlungspinal cord |
| spellingShingle | Minglang Gao Ziyao Zhang Kai Lai Yu Deng Chuanbing Zhao Zilong Lu Qing Geng Puerarin: A protective drug against ischemia-reperfusion injury Frontiers in Pharmacology puerarin ischemia-reperfusion injury (I/R) myocardium brain lung spinal cord |
| title | Puerarin: A protective drug against ischemia-reperfusion injury |
| title_full | Puerarin: A protective drug against ischemia-reperfusion injury |
| title_fullStr | Puerarin: A protective drug against ischemia-reperfusion injury |
| title_full_unstemmed | Puerarin: A protective drug against ischemia-reperfusion injury |
| title_short | Puerarin: A protective drug against ischemia-reperfusion injury |
| title_sort | puerarin a protective drug against ischemia reperfusion injury |
| topic | puerarin ischemia-reperfusion injury (I/R) myocardium brain lung spinal cord |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.927611/full |
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