A novel entity of massive multifocal osteolyses in the elderly
Osteolyses are common findings in elderly patients and most frequently represent malignant or locally aggressive bone tumors, infection, inflammatory and endocrine disorders, histiocytoses, and rare diseases such as Gorham-Stout syndrome. We here report on a novel entity of massive multifocal osteol...
| Үндсэн зохиолчид: | , , , , , , , , , |
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| Формат: | Өгүүллэг |
| Хэл сонгох: | English |
| Хэвлэсэн: |
Elsevier
2024-06-01
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| Цуврал: | Bone Reports |
| Нөхцлүүд: | |
| Онлайн хандалт: | http://www.sciencedirect.com/science/article/pii/S2352187224000329 |
| _version_ | 1827223047148404736 |
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| author | Patrick Orth Phillip Rolf Stahl Wolfgang Tränkenschuh Daniel Baumhoer Tim Kehl Hans-Peter Lehnhof Günther Schneider Eckart Meese Henning Madry Ulrike Fischer |
| author_facet | Patrick Orth Phillip Rolf Stahl Wolfgang Tränkenschuh Daniel Baumhoer Tim Kehl Hans-Peter Lehnhof Günther Schneider Eckart Meese Henning Madry Ulrike Fischer |
| author_sort | Patrick Orth |
| collection | DOAJ |
| description | Osteolyses are common findings in elderly patients and most frequently represent malignant or locally aggressive bone tumors, infection, inflammatory and endocrine disorders, histiocytoses, and rare diseases such as Gorham-Stout syndrome. We here report on a novel entity of massive multifocal osteolyses in both shoulders, the right hip and left knee joint and the dens of an 83-year-old patient not relatable to any previously known etiopathology of bone disorders. The soft tissue mass is of myxoid stroma with an unspecific granulomatous inflammatory process, aggressively destroying extensive cortical and cancellous bone segments and encroaching on articulating bones in diarthrodial large joints. Radiological, nuclear medical, serological, histological, and immunohistochemical analyses were incapable of further classifying the disease pattern within the existing scheme of pathology. Quantitative polymerase chain reaction and next generation sequencing revealed that mutations are not suggestive of any known hereditary or acquired bone disease. Possible treatment options include radionuclide therapy for pain palliation and percutaneous radiation to arrest bone resorption while surgical treatment is inevitable for pathological fractures. This case study shall increase the awareness of the musculoskeletal community and motivate to collect further information on this rare but mutilating disorder. |
| first_indexed | 2024-04-24T07:39:01Z |
| format | Article |
| id | doaj.art-abf73037286b4859bd6639d6fb757a81 |
| institution | Directory Open Access Journal |
| issn | 2352-1872 |
| language | English |
| last_indexed | 2025-03-21T16:48:10Z |
| publishDate | 2024-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Bone Reports |
| spelling | doaj.art-abf73037286b4859bd6639d6fb757a812024-06-16T05:45:12ZengElsevierBone Reports2352-18722024-06-0121101765A novel entity of massive multifocal osteolyses in the elderlyPatrick Orth0Phillip Rolf Stahl1Wolfgang Tränkenschuh2Daniel Baumhoer3Tim Kehl4Hans-Peter Lehnhof5Günther Schneider6Eckart Meese7Henning Madry8Ulrike Fischer9Department of Orthopaedic Surgery, Saarland University Medical Center, D-66421 Homburg, Germany; Center of Experimental Orthopaedics, Saarland University, D-66421 Homburg, Germany; Corresponding author at: Department of Orthopaedic Surgery, Saarland University Medical Center, Kirrberger Strasse, Building 37-38, D-66421 Homburg, Germany.Department of Pathology, MSB Medical School Berlin, D-14197 Berlin, GermanyDepartment of Pathology, Saarland University Medical Center, D-66421 Homburg, GermanyBone Tumor Reference Center, Institute of Pathology, University Hospital Basel, CH-4031 Basel, SwitzerlandCenter for Bioinformatics, Saarland Informatics Campus, D-66123 Saarbrücken, GermanyCenter for Bioinformatics, Saarland Informatics Campus, D-66123 Saarbrücken, GermanyDepartment of Radiology, Saarland University Medical Center, D-66421 Homburg, GermanyInstitute of Human Genetics, Saarland University, D-66421 Homburg, GermanyCenter of Experimental Orthopaedics, Saarland University, D-66421 Homburg, GermanyInstitute of Human Genetics, Saarland University, D-66421 Homburg, GermanyOsteolyses are common findings in elderly patients and most frequently represent malignant or locally aggressive bone tumors, infection, inflammatory and endocrine disorders, histiocytoses, and rare diseases such as Gorham-Stout syndrome. We here report on a novel entity of massive multifocal osteolyses in both shoulders, the right hip and left knee joint and the dens of an 83-year-old patient not relatable to any previously known etiopathology of bone disorders. The soft tissue mass is of myxoid stroma with an unspecific granulomatous inflammatory process, aggressively destroying extensive cortical and cancellous bone segments and encroaching on articulating bones in diarthrodial large joints. Radiological, nuclear medical, serological, histological, and immunohistochemical analyses were incapable of further classifying the disease pattern within the existing scheme of pathology. Quantitative polymerase chain reaction and next generation sequencing revealed that mutations are not suggestive of any known hereditary or acquired bone disease. Possible treatment options include radionuclide therapy for pain palliation and percutaneous radiation to arrest bone resorption while surgical treatment is inevitable for pathological fractures. This case study shall increase the awareness of the musculoskeletal community and motivate to collect further information on this rare but mutilating disorder.http://www.sciencedirect.com/science/article/pii/S2352187224000329OsteolysisElderlyNovel entity |
| spellingShingle | Patrick Orth Phillip Rolf Stahl Wolfgang Tränkenschuh Daniel Baumhoer Tim Kehl Hans-Peter Lehnhof Günther Schneider Eckart Meese Henning Madry Ulrike Fischer A novel entity of massive multifocal osteolyses in the elderly Bone Reports Osteolysis Elderly Novel entity |
| title | A novel entity of massive multifocal osteolyses in the elderly |
| title_full | A novel entity of massive multifocal osteolyses in the elderly |
| title_fullStr | A novel entity of massive multifocal osteolyses in the elderly |
| title_full_unstemmed | A novel entity of massive multifocal osteolyses in the elderly |
| title_short | A novel entity of massive multifocal osteolyses in the elderly |
| title_sort | novel entity of massive multifocal osteolyses in the elderly |
| topic | Osteolysis Elderly Novel entity |
| url | http://www.sciencedirect.com/science/article/pii/S2352187224000329 |
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