Pathogenic role of microRNAs in atherosclerotic ischemic stroke: Implications for diagnosis and therapy
Ischemic stroke resulting from atherosclerosis (particularly in the carotid artery) is one of the major subtypes of stroke and has a high incidence of death. Disordered lipid homeostasis, lipid deposition, local macrophage infiltration, smooth muscle cell proliferation, and plaque rupture are the ma...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2022-05-01
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| Series: | Genes and Diseases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352304221000088 |
| _version_ | 1797757631459229696 |
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| author | Qidi Jiang Yiran Li Quanli Wu Li Huang Jiasheng Xu Qingfu Zeng |
| author_facet | Qidi Jiang Yiran Li Quanli Wu Li Huang Jiasheng Xu Qingfu Zeng |
| author_sort | Qidi Jiang |
| collection | DOAJ |
| description | Ischemic stroke resulting from atherosclerosis (particularly in the carotid artery) is one of the major subtypes of stroke and has a high incidence of death. Disordered lipid homeostasis, lipid deposition, local macrophage infiltration, smooth muscle cell proliferation, and plaque rupture are the main pathological processes of atherosclerotic ischemic stroke. Hepatocytes, macrophages, endothelial cells and vascular smooth muscle cells are the main cell types participating in these processes. By inhibiting the expression of the target genes in these cells, microRNAs play a key role in regulating lipid disorders and atherosclerotic ischemic stroke. In this article, we listed the microRNAs implicated in the pathology of atherosclerotic ischemic stroke and aimed to explain their pro- or antiatherosclerotic roles. Our article provides an update on the potential diagnostic use of miRNAs for detecting growing plaques and impending clinical events. Finally, we provide a perspective on the therapeutic use of local microRNA delivery and discuss the challenges for this potential therapy. |
| first_indexed | 2024-03-12T18:17:24Z |
| format | Article |
| id | doaj.art-abf8b62b7aae4b248118f241bb99ae8b |
| institution | Directory Open Access Journal |
| issn | 2352-3042 |
| language | English |
| last_indexed | 2024-03-12T18:17:24Z |
| publishDate | 2022-05-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Genes and Diseases |
| spelling | doaj.art-abf8b62b7aae4b248118f241bb99ae8b2023-08-02T09:03:10ZengKeAi Communications Co., Ltd.Genes and Diseases2352-30422022-05-0193682696Pathogenic role of microRNAs in atherosclerotic ischemic stroke: Implications for diagnosis and therapyQidi Jiang0Yiran Li1Quanli Wu2Li Huang3Jiasheng Xu4Qingfu Zeng5Department of Biomedicine, Queen Mary University of London, Nanchang, Jiangxi 330006, PR China; Department of Clinical Laboratory, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, PR ChinaDepartment of Biomedicine, Queen Mary University of London, Nanchang, Jiangxi 330006, PR China; Department of Clinical Laboratory, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, PR ChinaSchool of Public Health, Nanchang University, Nanchang, Jiangxi 330001, PR ChinaDepartment of Vascular Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, PR ChinaDepartment of Vascular Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, PR ChinaDepartment of Vascular Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, PR China; Corresponding author. No. 1 Minde Road, Nanchang, Jiangxi 330006, PR China.Ischemic stroke resulting from atherosclerosis (particularly in the carotid artery) is one of the major subtypes of stroke and has a high incidence of death. Disordered lipid homeostasis, lipid deposition, local macrophage infiltration, smooth muscle cell proliferation, and plaque rupture are the main pathological processes of atherosclerotic ischemic stroke. Hepatocytes, macrophages, endothelial cells and vascular smooth muscle cells are the main cell types participating in these processes. By inhibiting the expression of the target genes in these cells, microRNAs play a key role in regulating lipid disorders and atherosclerotic ischemic stroke. In this article, we listed the microRNAs implicated in the pathology of atherosclerotic ischemic stroke and aimed to explain their pro- or antiatherosclerotic roles. Our article provides an update on the potential diagnostic use of miRNAs for detecting growing plaques and impending clinical events. Finally, we provide a perspective on the therapeutic use of local microRNA delivery and discuss the challenges for this potential therapy.http://www.sciencedirect.com/science/article/pii/S2352304221000088Atherosclerotic ischemic strokeECsMacrophagesmiRNAPlaque stabilityVSMCs |
| spellingShingle | Qidi Jiang Yiran Li Quanli Wu Li Huang Jiasheng Xu Qingfu Zeng Pathogenic role of microRNAs in atherosclerotic ischemic stroke: Implications for diagnosis and therapy Genes and Diseases Atherosclerotic ischemic stroke ECs Macrophages miRNA Plaque stability VSMCs |
| title | Pathogenic role of microRNAs in atherosclerotic ischemic stroke: Implications for diagnosis and therapy |
| title_full | Pathogenic role of microRNAs in atherosclerotic ischemic stroke: Implications for diagnosis and therapy |
| title_fullStr | Pathogenic role of microRNAs in atherosclerotic ischemic stroke: Implications for diagnosis and therapy |
| title_full_unstemmed | Pathogenic role of microRNAs in atherosclerotic ischemic stroke: Implications for diagnosis and therapy |
| title_short | Pathogenic role of microRNAs in atherosclerotic ischemic stroke: Implications for diagnosis and therapy |
| title_sort | pathogenic role of micrornas in atherosclerotic ischemic stroke implications for diagnosis and therapy |
| topic | Atherosclerotic ischemic stroke ECs Macrophages miRNA Plaque stability VSMCs |
| url | http://www.sciencedirect.com/science/article/pii/S2352304221000088 |
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