Add-on Effect of Levetiracetam on Cognitive Activity of Carbamazepine and Topiramate Treated Healthy Rats
Background: Many antiseizure drugs are used for non-epileptic indications like bipolar disorder, anxiety, neuropathic pain, prophylaxis of migraine, etc. Cognitive problems are known with many of these agents in epileptic situations but not to that extent in other situations. The antiepileptic L...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2015-06-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/6110/12654_CE[Ra]_F(P)_PF1(PAK)_PFA(AK)_PF2(SUAK)_PF2(PAG).pdf |
| Summary: | Background: Many antiseizure drugs are used for non-epileptic
indications like bipolar disorder, anxiety, neuropathic pain,
prophylaxis of migraine, etc. Cognitive problems are known
with many of these agents in epileptic situations but not to that
extent in other situations. The antiepileptic Levetiracetam has
been shown to improve a range of cognitive abilities.
Objective: To study the effect of levetiracetam, carbamazepine,
topiramate and co-administration of levetiracetam with
carbamazepine and topiramate on cognition in healthy rats.
Materials and Methods: Wistar albino rats of either sex
were randomly assigned to 6 groups (n=6). Treatment
groups: I - Normal saline; II, III & IV- Levetiracetam (180mg/
kg), Carbamazepine (50mg/kg) and Topiramate (20mg/kg)
respectively; V & VI- Levetiracetam + Carbamazepine and VILevetiracetam + Topiramate respectively orally for 21 days.
Morris Water Maze was used to study the spatial learning and
memory in rats and the change in Escape transfer latency (ETL)
was recorded to see the effect of drugs on it. Data analyzed by
ANOVA followed by Dunnett’s post-hoc test.
Results: Twenty one days drug treatment significantly increased
the ETL in rats treated with Topiramate (p=0.0001) and
combination of Levetiracetam and Topiramate (p<0.0001) from
their baseline values. At the same time, there was significant
reduction in the time spent in target quadrant in Topiramate
group (p= 0.033) and the combination group of Topiramate +
Levetiracetam (p=0.026). No significant change was observed
in the other groups when tested for both these parameters.
Conclusion: Topiramate causes impairment of spatial memory
in healthy rats after 21 days exposure and its combination with
Levetiracetam could not overcome this cognitive deficit. |
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| ISSN: | 2249-782X 0973-709X |