Prognostic factors predicting recurrence in invasive breast cancer: An analysis of radiological and clinicopathological factors
Summary: Background/Objective: The purpose of this study was to perform a comprehensive analysis of the radiological and clinicopathological factors that could predict recurrence of invasive breast cancer who underwent curative surgery without neoadjuvant chemotherapy. Methods: Three hundred and si...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2019-05-01
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| Series: | Asian Journal of Surgery |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1015958418305190 |
| _version_ | 1819209795800924160 |
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| author | Sae Rom Chung Woo Jung Choi Joo Hee Cha Hak Hee Kim Hee Jung Shin Eun Young Chae Ga Young Yoon |
| author_facet | Sae Rom Chung Woo Jung Choi Joo Hee Cha Hak Hee Kim Hee Jung Shin Eun Young Chae Ga Young Yoon |
| author_sort | Sae Rom Chung |
| collection | DOAJ |
| description | Summary: Background/Objective: The purpose of this study was to perform a comprehensive analysis of the radiological and clinicopathological factors that could predict recurrence of invasive breast cancer who underwent curative surgery without neoadjuvant chemotherapy. Methods: Three hundred and sixty-four consecutive women who underwent preoperative mammography, ultrasound, and breast magnetic resonance imaging for newly diagnosed invasive breast cancers and curative surgery between January and December 2010 were included. We analyzed the radiological findings of each modality and reviewed the histopathological features. A Cox proportional hazards model was used to determine the association between the radiological and clinicopathological parameters and disease-free survival (DFS). Results: During the median follow-up period of 5.3 years, 23 patients (6.3%) developed recurrences: locoregional recurrence in six patients, contralateral breast recurrence in three patients, and distant recurrences in 14 patients. Microcalcifications on mammography showed a tendency towards worse DFS. The multivariate Cox regression analysis showed that presence of lymphovascular invasion (LVI) (p = 0.006), negative progesterone receptor (PR) status (p < 0.001), and positive CK5/6 expression (p = 0.015) were independent significant variables predictive of worse DFS. Conclusion: Understanding the prognostic factors in patients with invasive breast cancer may provide considerable practical information about future treatment strategies. Keywords: Breast cancer, Prognostic factor, Recurrence, Survival |
| first_indexed | 2024-12-23T06:00:58Z |
| format | Article |
| id | doaj.art-abfc96c16014401e81a957d86e0f73ae |
| institution | Directory Open Access Journal |
| issn | 1015-9584 |
| language | English |
| last_indexed | 2024-12-23T06:00:58Z |
| publishDate | 2019-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Asian Journal of Surgery |
| spelling | doaj.art-abfc96c16014401e81a957d86e0f73ae2022-12-21T17:57:41ZengElsevierAsian Journal of Surgery1015-95842019-05-01425613620Prognostic factors predicting recurrence in invasive breast cancer: An analysis of radiological and clinicopathological factorsSae Rom Chung0Woo Jung Choi1Joo Hee Cha2Hak Hee Kim3Hee Jung Shin4Eun Young Chae5Ga Young Yoon6Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South KoreaCorresponding author. Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, 88, Olympic-ro 43-gil, Songpa-Gu, Seoul, 05505, South Korea. Fax: +82 2 476 0090.; Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South KoreaDepartment of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South KoreaDepartment of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South KoreaDepartment of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South KoreaDepartment of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South KoreaDepartment of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South KoreaSummary: Background/Objective: The purpose of this study was to perform a comprehensive analysis of the radiological and clinicopathological factors that could predict recurrence of invasive breast cancer who underwent curative surgery without neoadjuvant chemotherapy. Methods: Three hundred and sixty-four consecutive women who underwent preoperative mammography, ultrasound, and breast magnetic resonance imaging for newly diagnosed invasive breast cancers and curative surgery between January and December 2010 were included. We analyzed the radiological findings of each modality and reviewed the histopathological features. A Cox proportional hazards model was used to determine the association between the radiological and clinicopathological parameters and disease-free survival (DFS). Results: During the median follow-up period of 5.3 years, 23 patients (6.3%) developed recurrences: locoregional recurrence in six patients, contralateral breast recurrence in three patients, and distant recurrences in 14 patients. Microcalcifications on mammography showed a tendency towards worse DFS. The multivariate Cox regression analysis showed that presence of lymphovascular invasion (LVI) (p = 0.006), negative progesterone receptor (PR) status (p < 0.001), and positive CK5/6 expression (p = 0.015) were independent significant variables predictive of worse DFS. Conclusion: Understanding the prognostic factors in patients with invasive breast cancer may provide considerable practical information about future treatment strategies. Keywords: Breast cancer, Prognostic factor, Recurrence, Survivalhttp://www.sciencedirect.com/science/article/pii/S1015958418305190 |
| spellingShingle | Sae Rom Chung Woo Jung Choi Joo Hee Cha Hak Hee Kim Hee Jung Shin Eun Young Chae Ga Young Yoon Prognostic factors predicting recurrence in invasive breast cancer: An analysis of radiological and clinicopathological factors Asian Journal of Surgery |
| title | Prognostic factors predicting recurrence in invasive breast cancer: An analysis of radiological and clinicopathological factors |
| title_full | Prognostic factors predicting recurrence in invasive breast cancer: An analysis of radiological and clinicopathological factors |
| title_fullStr | Prognostic factors predicting recurrence in invasive breast cancer: An analysis of radiological and clinicopathological factors |
| title_full_unstemmed | Prognostic factors predicting recurrence in invasive breast cancer: An analysis of radiological and clinicopathological factors |
| title_short | Prognostic factors predicting recurrence in invasive breast cancer: An analysis of radiological and clinicopathological factors |
| title_sort | prognostic factors predicting recurrence in invasive breast cancer an analysis of radiological and clinicopathological factors |
| url | http://www.sciencedirect.com/science/article/pii/S1015958418305190 |
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