Factor quinolinone inhibitors disrupt spindles and multiple LSF (TFCP2)-protein interactions in mitosis, including with microtubule-associated proteins.

Factor quinolinone inhibitors disrupt spindles and multiple LSF (TFCP2)-protein interactions in mitosis, including with microtubule-associated proteins.

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Factor quinolinone inhibitors (FQIs), a first-in-class set of small molecule inhibitors targeted to the transcription factor LSF (TFCP2), exhibit promising cancer chemotherapeutic properties. FQI1, the initial lead compound identified, unexpectedly induced a concentration-dependent delay in mitotic...

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Bibliographic Details
Main Authors: Sarah A Yunes, Jennifer L S Willoughby, Julian H Kwan, Jessica M Biagi, Niranjana Pokharel, Hang Gyeong Chin, Emily A York, Kuan-Chung Su, Kelly George, Jagesh V Shah, Andrew Emili, Scott E Schaus, Ulla Hansen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0268857

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