Structural alterations of the salience network in patients with insular glioma
Abstract Objective The structural alteration that occurs within the salience network (SN) in patients with insular glioma is unclear. Therefore, we aimed to investigate the changes in the topological network and brain structure alterations within the SN in patients with insular glioma. Methods We en...
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-05-01
|
| Series: | Brain and Behavior |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/brb3.2969 |
| _version_ | 1827949606199099392 |
|---|---|
| author | Guanjie Hu Zhiqiang Wu Bowen Cao Qinyu Shi Zifeng Zhang Xiao Fan Yao Tang Zhangchun Cheng Xiefeng Wang Shenqi Jing Tao Li Junxia Zhang Yongping You |
| author_facet | Guanjie Hu Zhiqiang Wu Bowen Cao Qinyu Shi Zifeng Zhang Xiao Fan Yao Tang Zhangchun Cheng Xiefeng Wang Shenqi Jing Tao Li Junxia Zhang Yongping You |
| author_sort | Guanjie Hu |
| collection | DOAJ |
| description | Abstract Objective The structural alteration that occurs within the salience network (SN) in patients with insular glioma is unclear. Therefore, we aimed to investigate the changes in the topological network and brain structure alterations within the SN in patients with insular glioma. Methods We enrolled 46 patients with left insular glioma, 39 patients with right insular glioma, and 21 demographically matched healthy controls (HCs). We compared the topological network, gray matter (GM) volume, and fractional anisotropy (FA) between HCs and patients after controlling for the effects of age and gender. Results Patients with insular glioma showed topological network decline mainly in the insula, basal ganglia region, and anterior cingulate cortex (ACC). Compared with HCs, patients primarily showed GM volume increased in the ACC, inferior temporal gyrus (ITG), superior temporal gyrus (STG), temporal pole: middle temporal gyrus (TPOmid), insula, middle temporal gyrus (MTG), middle frontal gyrus, and superior occipital gyrus (SOG), but decreased in TPOmid, ITG, temporal pole: superior temporal gyrus, and SOG. FA declined mainly in the STG, MTG, ACC, superior frontal gyrus, and SOG, and also showed an increased cluster in SOG. Conclusions FA represents the integrity of the white matter. In patients with insular glioma, decreased FA may lead to the destruction of the topological network within the SN, which in turn may lead to the decrease of network efficiency and brain function, and the increase of GM volume may compensate for these changes. Overall, this pattern of structural changes provides new insight into the compensation model of insular glioma. |
| first_indexed | 2024-04-09T13:12:39Z |
| format | Article |
| id | doaj.art-abfcc0dd461a43829d36a359a15fe0c4 |
| institution | Directory Open Access Journal |
| issn | 2162-3279 |
| language | English |
| last_indexed | 2024-04-09T13:12:39Z |
| publishDate | 2023-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | Brain and Behavior |
| spelling | doaj.art-abfcc0dd461a43829d36a359a15fe0c42023-05-12T06:32:34ZengWileyBrain and Behavior2162-32792023-05-01135n/an/a10.1002/brb3.2969Structural alterations of the salience network in patients with insular gliomaGuanjie Hu0Zhiqiang Wu1Bowen Cao2Qinyu Shi3Zifeng Zhang4Xiao Fan5Yao Tang6Zhangchun Cheng7Xiefeng Wang8Shenqi Jing9Tao Li10Junxia Zhang11Yongping You12Department of Neurosurgery The First Affiliated Hospital of Nanjing Medical University Nanjing ChinaDepartment of Neurosurgery The First Affiliated Hospital of Nanjing Medical University Nanjing ChinaDepartment of Neurosurgery The First Affiliated Hospital of Nanjing Medical University Nanjing ChinaDepartment of Neurosurgery The First Affiliated Hospital of Nanjing Medical University Nanjing ChinaDepartment of Neurosurgery The First Affiliated Hospital of Nanjing Medical University Nanjing ChinaDepartment of Neurosurgery The First Affiliated Hospital of Nanjing Medical University Nanjing ChinaDepartment of Neurosurgery The First Affiliated Hospital of Nanjing Medical University Nanjing ChinaDepartment of Neurosurgery The First Affiliated Hospital of Nanjing Medical University Nanjing ChinaDepartment of Neurosurgery The First Affiliated Hospital of Nanjing Medical University Nanjing ChinaDepartment of Medical Informatics, School of Biomedical Engineering and Informatics Nanjing Medical University Nanjing ChinaShanghai Synyi Medical Technology Co., Ltd Shanghai ChinaDepartment of Neurosurgery The First Affiliated Hospital of Nanjing Medical University Nanjing ChinaDepartment of Neurosurgery The First Affiliated Hospital of Nanjing Medical University Nanjing ChinaAbstract Objective The structural alteration that occurs within the salience network (SN) in patients with insular glioma is unclear. Therefore, we aimed to investigate the changes in the topological network and brain structure alterations within the SN in patients with insular glioma. Methods We enrolled 46 patients with left insular glioma, 39 patients with right insular glioma, and 21 demographically matched healthy controls (HCs). We compared the topological network, gray matter (GM) volume, and fractional anisotropy (FA) between HCs and patients after controlling for the effects of age and gender. Results Patients with insular glioma showed topological network decline mainly in the insula, basal ganglia region, and anterior cingulate cortex (ACC). Compared with HCs, patients primarily showed GM volume increased in the ACC, inferior temporal gyrus (ITG), superior temporal gyrus (STG), temporal pole: middle temporal gyrus (TPOmid), insula, middle temporal gyrus (MTG), middle frontal gyrus, and superior occipital gyrus (SOG), but decreased in TPOmid, ITG, temporal pole: superior temporal gyrus, and SOG. FA declined mainly in the STG, MTG, ACC, superior frontal gyrus, and SOG, and also showed an increased cluster in SOG. Conclusions FA represents the integrity of the white matter. In patients with insular glioma, decreased FA may lead to the destruction of the topological network within the SN, which in turn may lead to the decrease of network efficiency and brain function, and the increase of GM volume may compensate for these changes. Overall, this pattern of structural changes provides new insight into the compensation model of insular glioma.https://doi.org/10.1002/brb3.2969fractional anisotropygray matter volumeinsula gliomatopological network |
| spellingShingle | Guanjie Hu Zhiqiang Wu Bowen Cao Qinyu Shi Zifeng Zhang Xiao Fan Yao Tang Zhangchun Cheng Xiefeng Wang Shenqi Jing Tao Li Junxia Zhang Yongping You Structural alterations of the salience network in patients with insular glioma Brain and Behavior fractional anisotropy gray matter volume insula glioma topological network |
| title | Structural alterations of the salience network in patients with insular glioma |
| title_full | Structural alterations of the salience network in patients with insular glioma |
| title_fullStr | Structural alterations of the salience network in patients with insular glioma |
| title_full_unstemmed | Structural alterations of the salience network in patients with insular glioma |
| title_short | Structural alterations of the salience network in patients with insular glioma |
| title_sort | structural alterations of the salience network in patients with insular glioma |
| topic | fractional anisotropy gray matter volume insula glioma topological network |
| url | https://doi.org/10.1002/brb3.2969 |
| work_keys_str_mv | AT guanjiehu structuralalterationsofthesaliencenetworkinpatientswithinsularglioma AT zhiqiangwu structuralalterationsofthesaliencenetworkinpatientswithinsularglioma AT bowencao structuralalterationsofthesaliencenetworkinpatientswithinsularglioma AT qinyushi structuralalterationsofthesaliencenetworkinpatientswithinsularglioma AT zifengzhang structuralalterationsofthesaliencenetworkinpatientswithinsularglioma AT xiaofan structuralalterationsofthesaliencenetworkinpatientswithinsularglioma AT yaotang structuralalterationsofthesaliencenetworkinpatientswithinsularglioma AT zhangchuncheng structuralalterationsofthesaliencenetworkinpatientswithinsularglioma AT xiefengwang structuralalterationsofthesaliencenetworkinpatientswithinsularglioma AT shenqijing structuralalterationsofthesaliencenetworkinpatientswithinsularglioma AT taoli structuralalterationsofthesaliencenetworkinpatientswithinsularglioma AT junxiazhang structuralalterationsofthesaliencenetworkinpatientswithinsularglioma AT yongpingyou structuralalterationsofthesaliencenetworkinpatientswithinsularglioma |