Memory persistence and differentiation into antibody-secreting cells accompanied by positive selection in longitudinal BCR repertoires

Memory persistence and differentiation into antibody-secreting cells accompanied by positive selection in longitudinal BCR repertoires

The stability and plasticity of B cell-mediated immune memory ensures the ability to respond to the repeated challenges. We have analyzed the longitudinal dynamics of immunoglobulin heavy chain repertoires from memory B cells, plasmablasts, and plasma cells from the peripheral blood of generally hea...

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Bibliographic Details
Main Authors: Artem Mikelov, Evgeniia I Alekseeva, Ekaterina A Komech, Dmitry B Staroverov, Maria A Turchaninova, Mikhail Shugay, Dmitriy M Chudakov, Georgii A Bazykin, Ivan V Zvyagin
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-09-01
Series:eLife
Subjects:
memory B cells
plasmablasts
plasma cells
BCR repertoire
somatic hypermutation
B cell somatic evolution
Online Access:https://elifesciences.org/articles/79254

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