Improving cellular uptake of therapeutic entities through interaction with components of cell membrane
Efficient cellular delivery of biologically active molecules is one of the key factors that affect the discovery and development of novel drugs. The plasma membrane is the first barrier that prevents direct translocation of chemic entities, and thus obstructs their efficient intracellular delivery....
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2019-01-01
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| Series: | Drug Delivery |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/10717544.2019.1582730 |
| _version_ | 1819015610089078784 |
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| author | Renshuai Zhang Xiaofei Qin Fandong Kong Pengwei Chen Guojun Pan |
| author_facet | Renshuai Zhang Xiaofei Qin Fandong Kong Pengwei Chen Guojun Pan |
| author_sort | Renshuai Zhang |
| collection | DOAJ |
| description | Efficient cellular delivery of biologically active molecules is one of the key factors that affect the discovery and development of novel drugs. The plasma membrane is the first barrier that prevents direct translocation of chemic entities, and thus obstructs their efficient intracellular delivery. Generally, hydrophilic small molecule drugs are poor permeability that reduce bioavailability and thus limit the clinic application. The cellular uptake of macromolecules and drug carriers is very inefficient without external assistance. Therefore, it is desirable to develop potent delivery systems for achieving effective intracellular delivery of chemic entities. Apart from of the types of delivery strategies, the composition of the cell membrane is critical for delivery efficiency due to the fact that cellular uptake is affected by the interaction between the chemical entity and the plasma membrane. In this review, we aimed to develop a profound understanding of the interactions between delivery systems and components of the plasma membrane. For the purpose, we attempt to present a broad overview of what delivery systems can be used to enhance the intracellular delivery of poorly permeable chemic entities, and how various delivery strategies are applied according to the components of plasma membrane. |
| first_indexed | 2024-12-21T02:34:28Z |
| format | Article |
| id | doaj.art-ac03b46667cd4f56972307f50b74f990 |
| institution | Directory Open Access Journal |
| issn | 1071-7544 1521-0464 |
| language | English |
| last_indexed | 2024-12-21T02:34:28Z |
| publishDate | 2019-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Drug Delivery |
| spelling | doaj.art-ac03b46667cd4f56972307f50b74f9902022-12-21T19:18:50ZengTaylor & Francis GroupDrug Delivery1071-75441521-04642019-01-0126132834210.1080/10717544.2019.15827301582730Improving cellular uptake of therapeutic entities through interaction with components of cell membraneRenshuai Zhang0Xiaofei Qin1Fandong Kong2Pengwei Chen3Guojun Pan4Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing Tech UniversityJiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing Tech UniversityInstitute of Tropical Bioscience and Biotechnology Chinese Academy of Tropical Agriculture SciencesInstitute of Tropical Bioscience and Biotechnology Chinese Academy of Tropical Agriculture SciencesTaishan Medical UniversityEfficient cellular delivery of biologically active molecules is one of the key factors that affect the discovery and development of novel drugs. The plasma membrane is the first barrier that prevents direct translocation of chemic entities, and thus obstructs their efficient intracellular delivery. Generally, hydrophilic small molecule drugs are poor permeability that reduce bioavailability and thus limit the clinic application. The cellular uptake of macromolecules and drug carriers is very inefficient without external assistance. Therefore, it is desirable to develop potent delivery systems for achieving effective intracellular delivery of chemic entities. Apart from of the types of delivery strategies, the composition of the cell membrane is critical for delivery efficiency due to the fact that cellular uptake is affected by the interaction between the chemical entity and the plasma membrane. In this review, we aimed to develop a profound understanding of the interactions between delivery systems and components of the plasma membrane. For the purpose, we attempt to present a broad overview of what delivery systems can be used to enhance the intracellular delivery of poorly permeable chemic entities, and how various delivery strategies are applied according to the components of plasma membrane.http://dx.doi.org/10.1080/10717544.2019.1582730cellular uptakedelivery systemsplasma membranepro-drugsdisulfide exchange |
| spellingShingle | Renshuai Zhang Xiaofei Qin Fandong Kong Pengwei Chen Guojun Pan Improving cellular uptake of therapeutic entities through interaction with components of cell membrane Drug Delivery cellular uptake delivery systems plasma membrane pro-drugs disulfide exchange |
| title | Improving cellular uptake of therapeutic entities through interaction with components of cell membrane |
| title_full | Improving cellular uptake of therapeutic entities through interaction with components of cell membrane |
| title_fullStr | Improving cellular uptake of therapeutic entities through interaction with components of cell membrane |
| title_full_unstemmed | Improving cellular uptake of therapeutic entities through interaction with components of cell membrane |
| title_short | Improving cellular uptake of therapeutic entities through interaction with components of cell membrane |
| title_sort | improving cellular uptake of therapeutic entities through interaction with components of cell membrane |
| topic | cellular uptake delivery systems plasma membrane pro-drugs disulfide exchange |
| url | http://dx.doi.org/10.1080/10717544.2019.1582730 |
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