The Appropriateness of Empiric Treatment of Urinary Tract Infections in a Tertiary Teaching Hospital in Joran: A Cross-Sectional Study
This is a cross-sectional study that was conducted at Jordan University Hospital (JUH) to evaluate the appropriateness of Urinary Tract Infection (UTI) empiric treatment based on microbial culture data and susceptibility testing. All urine cultures requested for adult patients (≥18 years) admitted t...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-05-01
|
| Series: | Antibiotics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-6382/11/5/629 |
| _version_ | 1797502067812597760 |
|---|---|
| author | Rama Alkhawaldeh Rana Abu Farha Khawla Abu Hammour Eman Alefishat |
| author_facet | Rama Alkhawaldeh Rana Abu Farha Khawla Abu Hammour Eman Alefishat |
| author_sort | Rama Alkhawaldeh |
| collection | DOAJ |
| description | This is a cross-sectional study that was conducted at Jordan University Hospital (JUH) to evaluate the appropriateness of Urinary Tract Infection (UTI) empiric treatment based on microbial culture data and susceptibility testing. All urine cultures requested for adult patients (≥18 years) admitted to JUH within the period from January 2019–July 2021 were reviewed and only those cultures with positive episodes of infection were considered. In this study, 6950 urine culture episodes were screened; among them, 34.5% (<i>n</i> = 2400) revealed positive results. Among those patients with positive culture episodes, 1600 patients (66.7%) were discharged before the availability of culture results and were excluded. Of the remaining eligible 800 patients, 701 (87.6%) received empiric treatment. In 26.8% of the eligible cases (<i>n</i> = 214), the prescribed empiric agents failed to have appropriate coverage of the identified pathogens, and in 14.6% of the cases (<i>n</i> = 117) the identified microorganisms were reported as resistant to the prescribed empiric agents. Furthermore, only 13.4% of the patients (<i>n</i> = 107) were appropriately treated for their UTI with empiric antibacterial agents. We were not able to judge the appropriateness of UTI treatment for one third (<i>n</i> = 263, 32.9%) of the patients, because they did not have susceptibility reports performed. This study revealed an alarmingly high rate of inappropriate treatment of UTIs, which encourages the emergence of bacterial resistance and affects health-related outcomes negatively. Therefore, antimicrobial stewardship programs must be applied to optimize antibiotic consumption in hospital settings. |
| first_indexed | 2024-03-10T03:27:34Z |
| format | Article |
| id | doaj.art-ac03bacd53514336b6a9ac52eeb148ad |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-10T03:27:34Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-ac03bacd53514336b6a9ac52eeb148ad2023-11-23T09:48:49ZengMDPI AGAntibiotics2079-63822022-05-0111562910.3390/antibiotics11050629The Appropriateness of Empiric Treatment of Urinary Tract Infections in a Tertiary Teaching Hospital in Joran: A Cross-Sectional StudyRama Alkhawaldeh0Rana Abu Farha1Khawla Abu Hammour2Eman Alefishat3Department of Clinical Pharmacy, Faculty of Pharmacy, Applied Science Private University, Amman 11931, JordanDepartment of Clinical Pharmacy, Faculty of Pharmacy, Applied Science Private University, Amman 11931, JordanDepartment Biopharmaceutics and Clinical Pharmacy, Faculty of Pharmacy, The University of Jordan, Amman 11942, JordanDepartment Biopharmaceutics and Clinical Pharmacy, Faculty of Pharmacy, The University of Jordan, Amman 11942, JordanThis is a cross-sectional study that was conducted at Jordan University Hospital (JUH) to evaluate the appropriateness of Urinary Tract Infection (UTI) empiric treatment based on microbial culture data and susceptibility testing. All urine cultures requested for adult patients (≥18 years) admitted to JUH within the period from January 2019–July 2021 were reviewed and only those cultures with positive episodes of infection were considered. In this study, 6950 urine culture episodes were screened; among them, 34.5% (<i>n</i> = 2400) revealed positive results. Among those patients with positive culture episodes, 1600 patients (66.7%) were discharged before the availability of culture results and were excluded. Of the remaining eligible 800 patients, 701 (87.6%) received empiric treatment. In 26.8% of the eligible cases (<i>n</i> = 214), the prescribed empiric agents failed to have appropriate coverage of the identified pathogens, and in 14.6% of the cases (<i>n</i> = 117) the identified microorganisms were reported as resistant to the prescribed empiric agents. Furthermore, only 13.4% of the patients (<i>n</i> = 107) were appropriately treated for their UTI with empiric antibacterial agents. We were not able to judge the appropriateness of UTI treatment for one third (<i>n</i> = 263, 32.9%) of the patients, because they did not have susceptibility reports performed. This study revealed an alarmingly high rate of inappropriate treatment of UTIs, which encourages the emergence of bacterial resistance and affects health-related outcomes negatively. Therefore, antimicrobial stewardship programs must be applied to optimize antibiotic consumption in hospital settings.https://www.mdpi.com/2079-6382/11/5/629antibiotic resistanceempiric antibioticurine culturesusceptibility testJordan |
| spellingShingle | Rama Alkhawaldeh Rana Abu Farha Khawla Abu Hammour Eman Alefishat The Appropriateness of Empiric Treatment of Urinary Tract Infections in a Tertiary Teaching Hospital in Joran: A Cross-Sectional Study Antibiotics antibiotic resistance empiric antibiotic urine culture susceptibility test Jordan |
| title | The Appropriateness of Empiric Treatment of Urinary Tract Infections in a Tertiary Teaching Hospital in Joran: A Cross-Sectional Study |
| title_full | The Appropriateness of Empiric Treatment of Urinary Tract Infections in a Tertiary Teaching Hospital in Joran: A Cross-Sectional Study |
| title_fullStr | The Appropriateness of Empiric Treatment of Urinary Tract Infections in a Tertiary Teaching Hospital in Joran: A Cross-Sectional Study |
| title_full_unstemmed | The Appropriateness of Empiric Treatment of Urinary Tract Infections in a Tertiary Teaching Hospital in Joran: A Cross-Sectional Study |
| title_short | The Appropriateness of Empiric Treatment of Urinary Tract Infections in a Tertiary Teaching Hospital in Joran: A Cross-Sectional Study |
| title_sort | appropriateness of empiric treatment of urinary tract infections in a tertiary teaching hospital in joran a cross sectional study |
| topic | antibiotic resistance empiric antibiotic urine culture susceptibility test Jordan |
| url | https://www.mdpi.com/2079-6382/11/5/629 |
| work_keys_str_mv | AT ramaalkhawaldeh theappropriatenessofempirictreatmentofurinarytractinfectionsinatertiaryteachinghospitalinjoranacrosssectionalstudy AT ranaabufarha theappropriatenessofempirictreatmentofurinarytractinfectionsinatertiaryteachinghospitalinjoranacrosssectionalstudy AT khawlaabuhammour theappropriatenessofempirictreatmentofurinarytractinfectionsinatertiaryteachinghospitalinjoranacrosssectionalstudy AT emanalefishat theappropriatenessofempirictreatmentofurinarytractinfectionsinatertiaryteachinghospitalinjoranacrosssectionalstudy AT ramaalkhawaldeh appropriatenessofempirictreatmentofurinarytractinfectionsinatertiaryteachinghospitalinjoranacrosssectionalstudy AT ranaabufarha appropriatenessofempirictreatmentofurinarytractinfectionsinatertiaryteachinghospitalinjoranacrosssectionalstudy AT khawlaabuhammour appropriatenessofempirictreatmentofurinarytractinfectionsinatertiaryteachinghospitalinjoranacrosssectionalstudy AT emanalefishat appropriatenessofempirictreatmentofurinarytractinfectionsinatertiaryteachinghospitalinjoranacrosssectionalstudy |