ImmunoPET imaging of amyloid-beta in a rat model of Alzheimer’s disease with a bispecific, brain-penetrating fusion protein

ImmunoPET imaging of amyloid-beta in a rat model of Alzheimer’s disease with a bispecific, brain-penetrating fusion protein

Abstract Background Hijacking the transferrin receptor (TfR) is an effective strategy to transport amyloid-beta (Aβ) immuno-positron emission tomography (immunoPET) ligands across the blood–brain barrier (BBB). Such ligands are more sensitive and specific than small-molecule ligands at detecting Aβ...

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Bibliographic Details
Main Authors: Gillian Bonvicini, Stina Syvänen, Ken G. Andersson, Merja Haaparanta-Solin, Francisco López-Picón, Dag Sehlin
Format: Article
Language:English
Published: BMC 2022-12-01
Series:Translational Neurodegeneration
Subjects:
ImmunoPET
Transferrin receptor
Alzheimer’s disease
Amyloid-beta
Online Access:https://doi.org/10.1186/s40035-022-00324-y

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