Fabrication of biodegradable hollow microsphere composites made of polybutylene adipate co-terephthalate/polyvinylpyrrolidone for drug delivery and sustained release
Sustained drug release has attracted increasing interest in targeted drug therapy. However, existing methods of drug therapy suffer drug action time, large fluctuations in the effective concentration of the drug, and the risk of side effects. Here, a biodegradable composite of polybutylene adipate c...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-06-01
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| Series: | Materials Today Bio |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006423000881 |
| _version_ | 1797796413658103808 |
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| author | Chuan Xie Qinqin Xiong Yuanzhi Wei Xin Li Jiajun Hu Min He Shinan Wei Jia Yu Sha Cheng Mashaal Ahmad Yufei Liu Sihai Luo Xi Zeng Jie Yu Heng Luo |
| author_facet | Chuan Xie Qinqin Xiong Yuanzhi Wei Xin Li Jiajun Hu Min He Shinan Wei Jia Yu Sha Cheng Mashaal Ahmad Yufei Liu Sihai Luo Xi Zeng Jie Yu Heng Luo |
| author_sort | Chuan Xie |
| collection | DOAJ |
| description | Sustained drug release has attracted increasing interest in targeted drug therapy. However, existing methods of drug therapy suffer drug action time, large fluctuations in the effective concentration of the drug, and the risk of side effects. Here, a biodegradable composite of polybutylene adipate co-terephthalate/polyvinylpyrrolidone (PBAT/PVP) consisting of electrospun hollow microspheres as sustained-released drug carriers is presented. The as-prepared PBAT/PVP composites show faster degradation rate and drug (Erlotinib) release than that of PBAT. Furthermore, PBAT/PVP composites loaded with Erlotinib provide sustained release effect, thus achieving a better efficacy than that after the direct injection of erlotinib due to the fact that the composites allow a high drug concentration in the tumor for a longer period. Hence, this work provides a potential effective solution for clinical drug therapy and tissue engineering using drug microspheres with a sustained release. |
| first_indexed | 2024-03-13T03:32:43Z |
| format | Article |
| id | doaj.art-ac05973c8a634f68a24b23ff38261114 |
| institution | Directory Open Access Journal |
| issn | 2590-0064 |
| language | English |
| last_indexed | 2024-03-13T03:32:43Z |
| publishDate | 2023-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj.art-ac05973c8a634f68a24b23ff382611142023-06-24T05:18:34ZengElsevierMaterials Today Bio2590-00642023-06-0120100628Fabrication of biodegradable hollow microsphere composites made of polybutylene adipate co-terephthalate/polyvinylpyrrolidone for drug delivery and sustained releaseChuan Xie0Qinqin Xiong1Yuanzhi Wei2Xin Li3Jiajun Hu4Min He5Shinan Wei6Jia Yu7Sha Cheng8Mashaal Ahmad9Yufei Liu10Sihai Luo11Xi Zeng12Jie Yu13Heng Luo14State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, 550014, China; Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang, 550014, China; Key Laboratory of Macrocyclic and Supramolecular Chemistry of Guizhou Province, Guizhou University, Guiyang, 550025, ChinaState Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, 550014, China; Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang, 550014, ChinaState Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, 550014, China; Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang, 550014, China; Key Laboratory of Macrocyclic and Supramolecular Chemistry of Guizhou Province, Guizhou University, Guiyang, 550025, ChinaDepartment of Polymer Material and Engineering, College of Materials and Metallurgy, Guizhou University, Guiyang, 550025, ChinaDepartment of Polymer Material and Engineering, College of Materials and Metallurgy, Guizhou University, Guiyang, 550025, ChinaDepartment of Polymer Material and Engineering, College of Materials and Metallurgy, Guizhou University, Guiyang, 550025, ChinaState Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, 550014, China; Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang, 550014, ChinaState Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, 550014, China; Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang, 550014, ChinaState Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, 550014, China; Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang, 550014, ChinaState Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, 550014, China; Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang, 550014, ChinaDepartment of Polymer Material and Engineering, College of Materials and Metallurgy, Guizhou University, Guiyang, 550025, China; National Engineering Research Center for Compounding and Modification of Polymeric Materials, Guiyang, 550014, China; Corresponding author. Department of Polymer Material and Engineering, College of Materials and Metallurgy, Guizhou University, Guiyang, 550025, China.Department of Chemistry, Norwegian University of Science and Technology (NTNU), 7491, Trondheim, Norway; Corresponding author.Key Laboratory of Macrocyclic and Supramolecular Chemistry of Guizhou Province, Guizhou University, Guiyang, 550025, ChinaDepartment of Polymer Material and Engineering, College of Materials and Metallurgy, Guizhou University, Guiyang, 550025, China; National Engineering Research Center for Compounding and Modification of Polymeric Materials, Guiyang, 550014, ChinaState Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, 550014, China; Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang, 550014, China; Corresponding author. State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, 550014, China.Sustained drug release has attracted increasing interest in targeted drug therapy. However, existing methods of drug therapy suffer drug action time, large fluctuations in the effective concentration of the drug, and the risk of side effects. Here, a biodegradable composite of polybutylene adipate co-terephthalate/polyvinylpyrrolidone (PBAT/PVP) consisting of electrospun hollow microspheres as sustained-released drug carriers is presented. The as-prepared PBAT/PVP composites show faster degradation rate and drug (Erlotinib) release than that of PBAT. Furthermore, PBAT/PVP composites loaded with Erlotinib provide sustained release effect, thus achieving a better efficacy than that after the direct injection of erlotinib due to the fact that the composites allow a high drug concentration in the tumor for a longer period. Hence, this work provides a potential effective solution for clinical drug therapy and tissue engineering using drug microspheres with a sustained release.http://www.sciencedirect.com/science/article/pii/S2590006423000881Polybutylene adipate co-terephthalate (PBAT)PolyvinylpyrrolidoneSustained-release drug carrierMicrospheresBiodegradable |
| spellingShingle | Chuan Xie Qinqin Xiong Yuanzhi Wei Xin Li Jiajun Hu Min He Shinan Wei Jia Yu Sha Cheng Mashaal Ahmad Yufei Liu Sihai Luo Xi Zeng Jie Yu Heng Luo Fabrication of biodegradable hollow microsphere composites made of polybutylene adipate co-terephthalate/polyvinylpyrrolidone for drug delivery and sustained release Materials Today Bio Polybutylene adipate co-terephthalate (PBAT) Polyvinylpyrrolidone Sustained-release drug carrier Microspheres Biodegradable |
| title | Fabrication of biodegradable hollow microsphere composites made of polybutylene adipate co-terephthalate/polyvinylpyrrolidone for drug delivery and sustained release |
| title_full | Fabrication of biodegradable hollow microsphere composites made of polybutylene adipate co-terephthalate/polyvinylpyrrolidone for drug delivery and sustained release |
| title_fullStr | Fabrication of biodegradable hollow microsphere composites made of polybutylene adipate co-terephthalate/polyvinylpyrrolidone for drug delivery and sustained release |
| title_full_unstemmed | Fabrication of biodegradable hollow microsphere composites made of polybutylene adipate co-terephthalate/polyvinylpyrrolidone for drug delivery and sustained release |
| title_short | Fabrication of biodegradable hollow microsphere composites made of polybutylene adipate co-terephthalate/polyvinylpyrrolidone for drug delivery and sustained release |
| title_sort | fabrication of biodegradable hollow microsphere composites made of polybutylene adipate co terephthalate polyvinylpyrrolidone for drug delivery and sustained release |
| topic | Polybutylene adipate co-terephthalate (PBAT) Polyvinylpyrrolidone Sustained-release drug carrier Microspheres Biodegradable |
| url | http://www.sciencedirect.com/science/article/pii/S2590006423000881 |
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