Cell type-specific DNA methylation in neonatal cord tissue and cord blood: a 850K-reference panel and comparison of cell types

Cell type-specific DNA methylation in neonatal cord tissue and cord blood: a 850K-reference panel and comparison of cell types

Accounting for cellular heterogeneity is essential in neonatal epigenome-wide association studies (EWAS) performed on heterogeneous tissues, such as umbilical cord tissue (CT) or cord blood (CB). Using a reference-panel-based statistical approach, the cell type composition of heterogeneous tissues c...

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Bibliographic Details
Main Authors: Xinyi Lin, Jane Yi Lin Tan, Ai Ling Teh, Ives Yubin Lim, Samantha J Liew, Julia L MacIsaac, Yap Seng Chong, Peter D Gluckman, Michael S Kobor, Clara Yujing Cheong, Neerja Karnani
Format: Article
Language:English
Published: Taylor & Francis Group 2018-09-01
Series:Epigenetics
Subjects:
cellular heterogeneity
neonatal epigenome wide association studies
tissue-specificity
dna methylation
reference panel
Online Access:http://dx.doi.org/10.1080/15592294.2018.1522929

Internet

http://dx.doi.org/10.1080/15592294.2018.1522929

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