Design and in vitro characterization of novel pulsatile delivery system of biguanide antidiabetic drug
Aim: This work shows the development of pulsatile capsular pellets of metformin hydrochloride and its characterisation. Material and Methods: The novel drug delivery system consisted of hydroxy propyl cellulose Type H. It has a lag time modifier and Eudragit L-100 and Eudragit S-100 in different con...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2020-01-01
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| Series: | Journal of Pharmacy and Bioallied Sciences |
| Subjects: | |
| Online Access: | http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2020;volume=12;issue=3;spage=356;epage=368;aulast=Pandey |
| _version_ | 1818531250011373568 |
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| author | Rahul Pandey William Selvamurthy |
| author_facet | Rahul Pandey William Selvamurthy |
| author_sort | Rahul Pandey |
| collection | DOAJ |
| description | Aim: This work shows the development of pulsatile capsular pellets of metformin hydrochloride and its characterisation. Material and Methods: The novel drug delivery system consisted of hydroxy propyl cellulose Type H. It has a lag time modifier and Eudragit L-100 and Eudragit S-100 in different concentrations as pH-dependent release modifier in the gastrointestinal tract. The pellets were subjected to in vitro release studies using USP dissolution apparatus type-II in distilled water, phosphate buffer of pH 6.8, and 0.1 N HCl and methanol. Ultraviolet (UV), infrared (IR), high-performance liquid chromatography (HPLC), and mass spectroscopy were performed for active pharmaceutical ingredients and formulations. Result: The study was characterized by the complete release of the drug in pulses after a well-defined lag time of 6 h (±0.20) (period of no drug release) for the treatment of type II diabetes mellitus. Conclusion: The stability studies on the selected formulation of Metformin were found to be stable, with shelf life of 1.94 years. Hence it may be concluded that the newly formulated pulsatile drug delivery systems of Metformin Hydrochloride, when ingested at the bed time in the night, produce effective control of the increased blood glucose level after intake of meals by allowing the drug to release after a lag time of 6 h (after meals). |
| first_indexed | 2024-12-11T17:30:00Z |
| format | Article |
| id | doaj.art-ac064cc8a166488ebba0e917b5efe828 |
| institution | Directory Open Access Journal |
| issn | 0975-7406 |
| language | English |
| last_indexed | 2024-12-11T17:30:00Z |
| publishDate | 2020-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Pharmacy and Bioallied Sciences |
| spelling | doaj.art-ac064cc8a166488ebba0e917b5efe8282022-12-22T00:56:52ZengWolters Kluwer Medknow PublicationsJournal of Pharmacy and Bioallied Sciences0975-74062020-01-0112335636810.4103/jpbs.JPBS_203_19Design and in vitro characterization of novel pulsatile delivery system of biguanide antidiabetic drugRahul PandeyWilliam SelvamurthyAim: This work shows the development of pulsatile capsular pellets of metformin hydrochloride and its characterisation. Material and Methods: The novel drug delivery system consisted of hydroxy propyl cellulose Type H. It has a lag time modifier and Eudragit L-100 and Eudragit S-100 in different concentrations as pH-dependent release modifier in the gastrointestinal tract. The pellets were subjected to in vitro release studies using USP dissolution apparatus type-II in distilled water, phosphate buffer of pH 6.8, and 0.1 N HCl and methanol. Ultraviolet (UV), infrared (IR), high-performance liquid chromatography (HPLC), and mass spectroscopy were performed for active pharmaceutical ingredients and formulations. Result: The study was characterized by the complete release of the drug in pulses after a well-defined lag time of 6 h (±0.20) (period of no drug release) for the treatment of type II diabetes mellitus. Conclusion: The stability studies on the selected formulation of Metformin were found to be stable, with shelf life of 1.94 years. Hence it may be concluded that the newly formulated pulsatile drug delivery systems of Metformin Hydrochloride, when ingested at the bed time in the night, produce effective control of the increased blood glucose level after intake of meals by allowing the drug to release after a lag time of 6 h (after meals).http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2020;volume=12;issue=3;spage=356;epage=368;aulast=Pandeyinfraredmass spectrametformin hydrochloridepelletspulsatile |
| spellingShingle | Rahul Pandey William Selvamurthy Design and in vitro characterization of novel pulsatile delivery system of biguanide antidiabetic drug Journal of Pharmacy and Bioallied Sciences infrared mass spectra metformin hydrochloride pellets pulsatile |
| title | Design and in vitro characterization of novel pulsatile delivery system of biguanide antidiabetic drug |
| title_full | Design and in vitro characterization of novel pulsatile delivery system of biguanide antidiabetic drug |
| title_fullStr | Design and in vitro characterization of novel pulsatile delivery system of biguanide antidiabetic drug |
| title_full_unstemmed | Design and in vitro characterization of novel pulsatile delivery system of biguanide antidiabetic drug |
| title_short | Design and in vitro characterization of novel pulsatile delivery system of biguanide antidiabetic drug |
| title_sort | design and in vitro characterization of novel pulsatile delivery system of biguanide antidiabetic drug |
| topic | infrared mass spectra metformin hydrochloride pellets pulsatile |
| url | http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2020;volume=12;issue=3;spage=356;epage=368;aulast=Pandey |
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