Some anti-diabetic properties of Prosopis farcta extracts in alloxan induced diabetic in adult rats
<em>Prosopis farcta</em>is belonged to Mimosaceae family<strong><em>, </em></strong>commonly known as mesquite<strong>.</strong> It was chosen to investigate their effect on α-glucosidase inhibitory activity (<em>in-vitro</em>), serum gluco...
| Main Authors: | , , |
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| Format: | Article |
| Language: | Arabic |
| Published: |
University of Mosul, College of Veterinary Medicine
2020-01-01
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| Series: | Iraqi Journal of Veterinary Sciences |
| Subjects: | |
| Online Access: | https://vetmedmosul.com/article_164339_3187c25338ba7a1511a2c118530a0cfb.pdf |
| Summary: | <em>Prosopis farcta</em>is belonged to Mimosaceae family<strong><em>, </em></strong>commonly known as mesquite<strong>.</strong> It was chosen to investigate their effect on α-glucosidase inhibitory activity (<em>in-vitro</em>), serum glucose and liver functions. Roots, fruits, and leaves of <em>P. farcta</em>, were extracted by <em>n</em>-hexane, ethyl acetate, and methanol. α-glucosidase inhibition was analyzed by using ELISA technique then half maximal inhibitory concentration IC<strong><sub>50</sub></strong> was found. The blood glucose levels were determined with a glucose analyzer model. The serum alkaline phosphatase (ALP), Alanine transaminase (ALT), aspartate aminotransferase (AST) and serum total bilirubin (TB) were estimated by using the Cobas diagnostic kit with a fully automated chemical analyzer. Diabetes was done by a single dose of 120 mg alloxan/kg b.w with subcutaneously injection. Ethyl acetate extracts of <em>P. farcta</em> showed the higher α-glucosidase inhibitory activity, and the best one was root extract. Treatments of the alloxan-induced diabetes rats were done by daily oral administration of different concentrations with <em>P. farcta </em>extracts of ethyl acetate for 28 days and the dose 200 mg/kg BW was the effective one. The root extract was the best one for reduction of serum glucose followed by leaves then fruits. Administration of root extract of <em>P. farcta</em> showed a decrease in the levels of ALP and TB in alloxan-induced diabetes rats. The fruit extract of <em>P. farcta </em>showed decreasing in the level of ALP in alloxan-induced diabetes rats. In conclusion, the <em>P. farcta</em> extracts for ethyl acetate have properties of hypoglycemic effect as well as improving some parameters related with diabetic complications of liver functions. |
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| ISSN: | 1607-3894 2071-1255 |