Some anti-diabetic properties of Prosopis farcta extracts in alloxan induced diabetic in adult rats
<em>Prosopis farcta</em>is belonged to Mimosaceae family<strong><em>, </em></strong>commonly known as mesquite<strong>.</strong> It was chosen to investigate their effect on α-glucosidase inhibitory activity (<em>in-vitro</em>), serum gluco...
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| Format: | Article |
| Language: | Arabic |
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University of Mosul, College of Veterinary Medicine
2020-01-01
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| Series: | Iraqi Journal of Veterinary Sciences |
| Subjects: | |
| Online Access: | https://vetmedmosul.com/article_164339_3187c25338ba7a1511a2c118530a0cfb.pdf |
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| author | Ismael H. Mohammed Ismail S. Kakey Mahdi M. Farimani |
| author_facet | Ismael H. Mohammed Ismail S. Kakey Mahdi M. Farimani |
| author_sort | Ismael H. Mohammed |
| collection | DOAJ |
| description | <em>Prosopis farcta</em>is belonged to Mimosaceae family<strong><em>, </em></strong>commonly known as mesquite<strong>.</strong> It was chosen to investigate their effect on α-glucosidase inhibitory activity (<em>in-vitro</em>), serum glucose and liver functions. Roots, fruits, and leaves of <em>P. farcta</em>, were extracted by <em>n</em>-hexane, ethyl acetate, and methanol. α-glucosidase inhibition was analyzed by using ELISA technique then half maximal inhibitory concentration IC<strong><sub>50</sub></strong> was found. The blood glucose levels were determined with a glucose analyzer model. The serum alkaline phosphatase (ALP), Alanine transaminase (ALT), aspartate aminotransferase (AST) and serum total bilirubin (TB) were estimated by using the Cobas diagnostic kit with a fully automated chemical analyzer. Diabetes was done by a single dose of 120 mg alloxan/kg b.w with subcutaneously injection. Ethyl acetate extracts of <em>P. farcta</em> showed the higher α-glucosidase inhibitory activity, and the best one was root extract. Treatments of the alloxan-induced diabetes rats were done by daily oral administration of different concentrations with <em>P. farcta </em>extracts of ethyl acetate for 28 days and the dose 200 mg/kg BW was the effective one. The root extract was the best one for reduction of serum glucose followed by leaves then fruits. Administration of root extract of <em>P. farcta</em> showed a decrease in the levels of ALP and TB in alloxan-induced diabetes rats. The fruit extract of <em>P. farcta </em>showed decreasing in the level of ALP in alloxan-induced diabetes rats. In conclusion, the <em>P. farcta</em> extracts for ethyl acetate have properties of hypoglycemic effect as well as improving some parameters related with diabetic complications of liver functions. |
| first_indexed | 2024-12-18T11:40:56Z |
| format | Article |
| id | doaj.art-ac07085c37da42efb10d24f727fbd76b |
| institution | Directory Open Access Journal |
| issn | 1607-3894 2071-1255 |
| language | Arabic |
| last_indexed | 2024-12-18T11:40:56Z |
| publishDate | 2020-01-01 |
| publisher | University of Mosul, College of Veterinary Medicine |
| record_format | Article |
| series | Iraqi Journal of Veterinary Sciences |
| spelling | doaj.art-ac07085c37da42efb10d24f727fbd76b2022-12-21T21:09:25ZaraUniversity of Mosul, College of Veterinary MedicineIraqi Journal of Veterinary Sciences1607-38942071-12552020-01-0134110911310.33899/ijvs.2019.125557.1076164339Some anti-diabetic properties of Prosopis farcta extracts in alloxan induced diabetic in adult ratsIsmael H. Mohammed0Ismail S. Kakey1Mahdi M. Farimani2Department of Medical Microbiology, Faculty of Science and Health, Koya University, Koya, IraqDepartment of Biology, Faculty of Science and Health, Koya University, Koya, IraqDepartment of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, Evin, Tehran, Iran<em>Prosopis farcta</em>is belonged to Mimosaceae family<strong><em>, </em></strong>commonly known as mesquite<strong>.</strong> It was chosen to investigate their effect on α-glucosidase inhibitory activity (<em>in-vitro</em>), serum glucose and liver functions. Roots, fruits, and leaves of <em>P. farcta</em>, were extracted by <em>n</em>-hexane, ethyl acetate, and methanol. α-glucosidase inhibition was analyzed by using ELISA technique then half maximal inhibitory concentration IC<strong><sub>50</sub></strong> was found. The blood glucose levels were determined with a glucose analyzer model. The serum alkaline phosphatase (ALP), Alanine transaminase (ALT), aspartate aminotransferase (AST) and serum total bilirubin (TB) were estimated by using the Cobas diagnostic kit with a fully automated chemical analyzer. Diabetes was done by a single dose of 120 mg alloxan/kg b.w with subcutaneously injection. Ethyl acetate extracts of <em>P. farcta</em> showed the higher α-glucosidase inhibitory activity, and the best one was root extract. Treatments of the alloxan-induced diabetes rats were done by daily oral administration of different concentrations with <em>P. farcta </em>extracts of ethyl acetate for 28 days and the dose 200 mg/kg BW was the effective one. The root extract was the best one for reduction of serum glucose followed by leaves then fruits. Administration of root extract of <em>P. farcta</em> showed a decrease in the levels of ALP and TB in alloxan-induced diabetes rats. The fruit extract of <em>P. farcta </em>showed decreasing in the level of ALP in alloxan-induced diabetes rats. In conclusion, the <em>P. farcta</em> extracts for ethyl acetate have properties of hypoglycemic effect as well as improving some parameters related with diabetic complications of liver functions.https://vetmedmosul.com/article_164339_3187c25338ba7a1511a2c118530a0cfb.pdfprosopis farctadiabetesrats |
| spellingShingle | Ismael H. Mohammed Ismail S. Kakey Mahdi M. Farimani Some anti-diabetic properties of Prosopis farcta extracts in alloxan induced diabetic in adult rats Iraqi Journal of Veterinary Sciences prosopis farcta diabetes rats |
| title | Some anti-diabetic properties of Prosopis farcta extracts in alloxan induced diabetic in adult rats |
| title_full | Some anti-diabetic properties of Prosopis farcta extracts in alloxan induced diabetic in adult rats |
| title_fullStr | Some anti-diabetic properties of Prosopis farcta extracts in alloxan induced diabetic in adult rats |
| title_full_unstemmed | Some anti-diabetic properties of Prosopis farcta extracts in alloxan induced diabetic in adult rats |
| title_short | Some anti-diabetic properties of Prosopis farcta extracts in alloxan induced diabetic in adult rats |
| title_sort | some anti diabetic properties of prosopis farcta extracts in alloxan induced diabetic in adult rats |
| topic | prosopis farcta diabetes rats |
| url | https://vetmedmosul.com/article_164339_3187c25338ba7a1511a2c118530a0cfb.pdf |
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