Protein Phosphatases—A Touchy Enemy in the Battle Against Glioblastomas: A Review
Glioblastoma (GBM) is the most common malignant tumor arising from brain parenchyma. Although many efforts have been made to develop therapies for GBM, the prognosis still remains poor, mainly because of the difficulty in total resection of the tumor mass from brain tissue and the resistance of the...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-02-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/11/2/241 |
| _version_ | 1797723064292605952 |
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| author | Arata Tomiyama Tatsuya Kobayashi Kentaro Mori Koichi Ichimura |
| author_facet | Arata Tomiyama Tatsuya Kobayashi Kentaro Mori Koichi Ichimura |
| author_sort | Arata Tomiyama |
| collection | DOAJ |
| description | Glioblastoma (GBM) is the most common malignant tumor arising from brain parenchyma. Although many efforts have been made to develop therapies for GBM, the prognosis still remains poor, mainly because of the difficulty in total resection of the tumor mass from brain tissue and the resistance of the residual tumor against standard chemoradiotherapy. Therefore, novel adjuvant therapies are urgently needed. Recent genome-wide analyses of GBM cases have clarified molecular signaling mechanisms underlying GBM biology. However, results of clinical trials targeting phosphorylation-mediated signaling have been unsatisfactory to date. Protein phosphatases are enzymes that antagonize phosphorylation signaling by dephosphorylating phosphorylated signaling molecules. Recently, the critical roles of phosphatases in the regulation of oncogenic signaling in malignant tumor cells have been reported, and tumorigenic roles of deregulated phosphatases have been demonstrated in GBM. However, a detailed mechanism underlying phosphatase-mediated signaling transduction in the regulation of GBM has not been elucidated, and such information is necessary to apply phosphatases as a therapeutic target for GBM. This review highlights and summarizes the phosphatases that have crucial roles in the regulation of oncogenic signaling in GBM cells. |
| first_indexed | 2024-03-12T09:57:40Z |
| format | Article |
| id | doaj.art-ac072db64be747d0b3d23fe0c6d7fd0c |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-12T09:57:40Z |
| publishDate | 2019-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-ac072db64be747d0b3d23fe0c6d7fd0c2023-09-02T12:04:27ZengMDPI AGCancers2072-66942019-02-0111224110.3390/cancers11020241cancers11020241Protein Phosphatases—A Touchy Enemy in the Battle Against Glioblastomas: A ReviewArata Tomiyama0Tatsuya Kobayashi1Kentaro Mori2Koichi Ichimura3Division of Brain Tumor Translational Research, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, JapanDivision of Brain Tumor Translational Research, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, JapanDepartment of Neurosurgery, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama 359-8513, JapanDivision of Brain Tumor Translational Research, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, JapanGlioblastoma (GBM) is the most common malignant tumor arising from brain parenchyma. Although many efforts have been made to develop therapies for GBM, the prognosis still remains poor, mainly because of the difficulty in total resection of the tumor mass from brain tissue and the resistance of the residual tumor against standard chemoradiotherapy. Therefore, novel adjuvant therapies are urgently needed. Recent genome-wide analyses of GBM cases have clarified molecular signaling mechanisms underlying GBM biology. However, results of clinical trials targeting phosphorylation-mediated signaling have been unsatisfactory to date. Protein phosphatases are enzymes that antagonize phosphorylation signaling by dephosphorylating phosphorylated signaling molecules. Recently, the critical roles of phosphatases in the regulation of oncogenic signaling in malignant tumor cells have been reported, and tumorigenic roles of deregulated phosphatases have been demonstrated in GBM. However, a detailed mechanism underlying phosphatase-mediated signaling transduction in the regulation of GBM has not been elucidated, and such information is necessary to apply phosphatases as a therapeutic target for GBM. This review highlights and summarizes the phosphatases that have crucial roles in the regulation of oncogenic signaling in GBM cells.https://www.mdpi.com/2072-6694/11/2/241protein phosphataseglioblastomasignalingtherapy |
| spellingShingle | Arata Tomiyama Tatsuya Kobayashi Kentaro Mori Koichi Ichimura Protein Phosphatases—A Touchy Enemy in the Battle Against Glioblastomas: A Review Cancers protein phosphatase glioblastoma signaling therapy |
| title | Protein Phosphatases—A Touchy Enemy in the Battle Against Glioblastomas: A Review |
| title_full | Protein Phosphatases—A Touchy Enemy in the Battle Against Glioblastomas: A Review |
| title_fullStr | Protein Phosphatases—A Touchy Enemy in the Battle Against Glioblastomas: A Review |
| title_full_unstemmed | Protein Phosphatases—A Touchy Enemy in the Battle Against Glioblastomas: A Review |
| title_short | Protein Phosphatases—A Touchy Enemy in the Battle Against Glioblastomas: A Review |
| title_sort | protein phosphatases a touchy enemy in the battle against glioblastomas a review |
| topic | protein phosphatase glioblastoma signaling therapy |
| url | https://www.mdpi.com/2072-6694/11/2/241 |
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