Effect of 0.01% atropine eyedrops on intraocular pressure in schoolchildren: a randomized clinical trial
AIM: To assess the effect of 0.01% atropine eye drops on intraocular pressure (IOP) in myopic children. METHODS: A placebo-controlled, double-masked, randomized study. Totally 220 children aged 6 to 12y with myopia ranging from -1.00 to -6.00 D in both eyes were enrolled. Children were randomized in...
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| Format: | Article |
| Language: | English |
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Press of International Journal of Ophthalmology (IJO PRESS)
2022-09-01
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| Series: | International Journal of Ophthalmology |
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| Online Access: | http://ies.ijo.cn/en_publish/2022/9/20220904.pdf |
| _version_ | 1811185490324357120 |
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| author | Javaria Bukhari Shi-Fei Wei Shi-Ming Li Wen-Zai An Jia-Ling Du Xin-Tong Liang Jia-He Gan Jia-Xin Tian Wei-Ling Bai Zhi-Ning Cai Lei Yin Ning-Li Wang |
| author_facet | Javaria Bukhari Shi-Fei Wei Shi-Ming Li Wen-Zai An Jia-Ling Du Xin-Tong Liang Jia-He Gan Jia-Xin Tian Wei-Ling Bai Zhi-Ning Cai Lei Yin Ning-Li Wang |
| author_sort | Javaria Bukhari |
| collection | DOAJ |
| description | AIM: To assess the effect of 0.01% atropine eye drops on intraocular pressure (IOP) in myopic children. METHODS: A placebo-controlled, double-masked, randomized study. Totally 220 children aged 6 to 12y with myopia ranging from -1.00 to -6.00 D in both eyes were enrolled. Children were randomized in a 1:1 ratio to either 0.01% atropine eye drops or a placebo group using generated random numbers. All participants underwent the examination of IOP and cycloplegic refraction at baseline, 6 and 12mo. The change of IOP and the proportion of subjects with increased IOP in atropine and placebo groups were compared. RESULTS: Of 220 children, 117 were boys (53.2%). A total of 159 (72.3%) participants completed the follow-up at the 1-year study. At baseline, the mean IOP was 15.74 mm Hg (95%CI, 15.13 to 16.34 mm Hg) for the 0.01% atropine group and 15.59 mm Hg (95%CI, 15.00 to 16.19 mm Hg) for placebo group (mean difference, 0.14 mm Hg; P=0.743) after adjusting for central corneal thickness at baseline. At one year follow-up, the mean change of IOP was 0.16 mm Hg (95%CI, -0.43 to 0.76 mm Hg) for the 0.01% atropine group and -0.11 mm Hg (95%CI, -0.71 to 0.50 mm Hg) for placebo group (mean difference, 0.27 mm Hg; P=0.525) after adjusting for central corneal thickness. The 51.4% of children have increased IOP in the 0.01% atropine group, compared with 45.9% in the placebo group (P=0.511). CONCLUSION: The 0.01% atropine eye drops do not significantly affect the risk of elevated IOP. It is relatively safer to use in the studies that try to minimize myopia progression. However, a further long-duration study is required to be validated. |
| first_indexed | 2024-04-11T13:30:14Z |
| format | Article |
| id | doaj.art-ac0771b0bb1b4315a16c28d930329ebe |
| institution | Directory Open Access Journal |
| issn | 2222-3959 2227-4898 |
| language | English |
| last_indexed | 2024-04-11T13:30:14Z |
| publishDate | 2022-09-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | International Journal of Ophthalmology |
| spelling | doaj.art-ac0771b0bb1b4315a16c28d930329ebe2022-12-22T04:21:50ZengPress of International Journal of Ophthalmology (IJO PRESS)International Journal of Ophthalmology2222-39592227-48982022-09-011591431143610.18240/ijo.2022.09.0420220904Effect of 0.01% atropine eyedrops on intraocular pressure in schoolchildren: a randomized clinical trialJavaria Bukhari0Shi-Fei Wei1Shi-Ming Li2Wen-Zai An3Jia-Ling Du4Xin-Tong Liang5Jia-He Gan6Jia-Xin Tian7Wei-Ling Bai8Zhi-Ning Cai9Lei Yin10Ning-Li Wang11Ning-Li Wang and Shi-Fei Wei. Beijing Tongren Hospital, 1 Dongjiaominxiang Street, Dongcheng District, Beijing 100730, China. wningli@vip.163.com; wsfstep2015@163.comBeijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical UniversityBeijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical UniversityBeijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical UniversityBeijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical UniversityBeijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical UniversityBeijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical UniversityBeijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical UniversityBeijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical UniversityBeijing Ophthalmology & Visual Sciences Key Laboratory, Beijing 100730, ChinaCapital Medical University, Beijing 100069, ChinaBeijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical UniversityAIM: To assess the effect of 0.01% atropine eye drops on intraocular pressure (IOP) in myopic children. METHODS: A placebo-controlled, double-masked, randomized study. Totally 220 children aged 6 to 12y with myopia ranging from -1.00 to -6.00 D in both eyes were enrolled. Children were randomized in a 1:1 ratio to either 0.01% atropine eye drops or a placebo group using generated random numbers. All participants underwent the examination of IOP and cycloplegic refraction at baseline, 6 and 12mo. The change of IOP and the proportion of subjects with increased IOP in atropine and placebo groups were compared. RESULTS: Of 220 children, 117 were boys (53.2%). A total of 159 (72.3%) participants completed the follow-up at the 1-year study. At baseline, the mean IOP was 15.74 mm Hg (95%CI, 15.13 to 16.34 mm Hg) for the 0.01% atropine group and 15.59 mm Hg (95%CI, 15.00 to 16.19 mm Hg) for placebo group (mean difference, 0.14 mm Hg; P=0.743) after adjusting for central corneal thickness at baseline. At one year follow-up, the mean change of IOP was 0.16 mm Hg (95%CI, -0.43 to 0.76 mm Hg) for the 0.01% atropine group and -0.11 mm Hg (95%CI, -0.71 to 0.50 mm Hg) for placebo group (mean difference, 0.27 mm Hg; P=0.525) after adjusting for central corneal thickness. The 51.4% of children have increased IOP in the 0.01% atropine group, compared with 45.9% in the placebo group (P=0.511). CONCLUSION: The 0.01% atropine eye drops do not significantly affect the risk of elevated IOP. It is relatively safer to use in the studies that try to minimize myopia progression. However, a further long-duration study is required to be validated.http://ies.ijo.cn/en_publish/2022/9/20220904.pdfintraocular pressure0.01% atropine eye dropsmyopic children |
| spellingShingle | Javaria Bukhari Shi-Fei Wei Shi-Ming Li Wen-Zai An Jia-Ling Du Xin-Tong Liang Jia-He Gan Jia-Xin Tian Wei-Ling Bai Zhi-Ning Cai Lei Yin Ning-Li Wang Effect of 0.01% atropine eyedrops on intraocular pressure in schoolchildren: a randomized clinical trial International Journal of Ophthalmology intraocular pressure 0.01% atropine eye drops myopic children |
| title | Effect of 0.01% atropine eyedrops on intraocular pressure in schoolchildren: a randomized clinical trial |
| title_full | Effect of 0.01% atropine eyedrops on intraocular pressure in schoolchildren: a randomized clinical trial |
| title_fullStr | Effect of 0.01% atropine eyedrops on intraocular pressure in schoolchildren: a randomized clinical trial |
| title_full_unstemmed | Effect of 0.01% atropine eyedrops on intraocular pressure in schoolchildren: a randomized clinical trial |
| title_short | Effect of 0.01% atropine eyedrops on intraocular pressure in schoolchildren: a randomized clinical trial |
| title_sort | effect of 0 01 atropine eyedrops on intraocular pressure in schoolchildren a randomized clinical trial |
| topic | intraocular pressure 0.01% atropine eye drops myopic children |
| url | http://ies.ijo.cn/en_publish/2022/9/20220904.pdf |
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