Sex-Associated Differences in Short-Term Outcomes in Patients with Deep Sternal Wound Infection after Open-Heart Surgery
Deep sternal wound infection (DSWI) is a feared complication after cardiac surgery. The impact of sex-related differences on wound infection prevalence is poorly understood. Our aim was to evaluate the effect of sex on short-term outcomes in patients with DSWI after open-heart surgery. The study was...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/24/7510 |
| _version_ | 1797457015187963904 |
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| author | Ihor Krasivskyi Borko Ivanov Kaveh Eghbalzadeh Frederike Fehlau Stephen Gerfer Clara Großmann Ahmed Elderia Anton Sabashnikov Parwis Baradaran Rahmanian Navid Mader Ilija Djordjevic Thorsten Wahlers |
| author_facet | Ihor Krasivskyi Borko Ivanov Kaveh Eghbalzadeh Frederike Fehlau Stephen Gerfer Clara Großmann Ahmed Elderia Anton Sabashnikov Parwis Baradaran Rahmanian Navid Mader Ilija Djordjevic Thorsten Wahlers |
| author_sort | Ihor Krasivskyi |
| collection | DOAJ |
| description | Deep sternal wound infection (DSWI) is a feared complication after cardiac surgery. The impact of sex-related differences on wound infection prevalence is poorly understood. Our aim was to evaluate the effect of sex on short-term outcomes in patients with DSWI after open-heart surgery. The study was a retrospective cohort study. A total of 217 patients with DSWI were identified and retrospectively analyzed using our institutional database. Patients were divided into two groups: males (<i>n</i> = 150) and females (<i>n</i> = 67). This study also includes a propensity score based matching (PSM) analysis (male group (<i>n</i> = 62) and female group (<i>n</i> = 62)) to examine the unequal groups. Mean age (<i>p</i> = 0.088) and mean body mass index (BMI) (<i>p</i> = 0.905) did not significantly differ between both groups. Vacuum assisted closure (VAC) therapy was performed among most patients (82.3% (male group) vs. 83.9% (female group), <i>p</i> = 0.432). The most commonly isolated bacteria from the wounds were Staphylococcus epidermidis and Staphylococcus aureus in both groups. Acute renal failure was significantly higher (<i>p</i> = 0.010) in the male group compared to the female group. However, dialysis rate did not significantly differ (<i>p</i> = 0.491) between male and female groups. Further secondary outcomes showed no major differences between the groups. Likewise, in-hospital mortality rate did not differ significantly (<i>p</i> = 0.680) between both groups. Based on our data, sex has no impact on deep wound infection prevalence after cardiac surgery. |
| first_indexed | 2024-03-09T16:16:05Z |
| format | Article |
| id | doaj.art-ac07e21fbc6240f5b806ca8784121f70 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T16:16:05Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-ac07e21fbc6240f5b806ca8784121f702023-11-24T15:46:51ZengMDPI AGJournal of Clinical Medicine2077-03832022-12-011124751010.3390/jcm11247510Sex-Associated Differences in Short-Term Outcomes in Patients with Deep Sternal Wound Infection after Open-Heart SurgeryIhor Krasivskyi0Borko Ivanov1Kaveh Eghbalzadeh2Frederike Fehlau3Stephen Gerfer4Clara Großmann5Ahmed Elderia6Anton Sabashnikov7Parwis Baradaran Rahmanian8Navid Mader9Ilija Djordjevic10Thorsten Wahlers11Department of Cardiothoracic Surgery, University Hospital Cologne, 50937 Cologne, GermanyDepartment of Cardiothoracic Surgery, Helios Hospital Siegburg, 53721 Siegburg, GermanyDepartment of Cardiothoracic Surgery, University Hospital Cologne, 50937 Cologne, GermanyDepartment of Cardiothoracic Surgery, University Hospital Cologne, 50937 Cologne, GermanyDepartment of Cardiothoracic Surgery, University Hospital Cologne, 50937 Cologne, GermanyDepartment of Cardiothoracic Surgery, University Hospital Cologne, 50937 Cologne, GermanyDepartment of Cardiothoracic Surgery, University Hospital Cologne, 50937 Cologne, GermanyDepartment of Cardiothoracic Surgery, University Hospital Cologne, 50937 Cologne, GermanyDepartment of Cardiothoracic Surgery, University Hospital Cologne, 50937 Cologne, GermanyDepartment of Cardiothoracic Surgery, University Hospital Cologne, 50937 Cologne, GermanyDepartment of Cardiothoracic Surgery, University Hospital Cologne, 50937 Cologne, GermanyDepartment of Cardiothoracic Surgery, University Hospital Cologne, 50937 Cologne, GermanyDeep sternal wound infection (DSWI) is a feared complication after cardiac surgery. The impact of sex-related differences on wound infection prevalence is poorly understood. Our aim was to evaluate the effect of sex on short-term outcomes in patients with DSWI after open-heart surgery. The study was a retrospective cohort study. A total of 217 patients with DSWI were identified and retrospectively analyzed using our institutional database. Patients were divided into two groups: males (<i>n</i> = 150) and females (<i>n</i> = 67). This study also includes a propensity score based matching (PSM) analysis (male group (<i>n</i> = 62) and female group (<i>n</i> = 62)) to examine the unequal groups. Mean age (<i>p</i> = 0.088) and mean body mass index (BMI) (<i>p</i> = 0.905) did not significantly differ between both groups. Vacuum assisted closure (VAC) therapy was performed among most patients (82.3% (male group) vs. 83.9% (female group), <i>p</i> = 0.432). The most commonly isolated bacteria from the wounds were Staphylococcus epidermidis and Staphylococcus aureus in both groups. Acute renal failure was significantly higher (<i>p</i> = 0.010) in the male group compared to the female group. However, dialysis rate did not significantly differ (<i>p</i> = 0.491) between male and female groups. Further secondary outcomes showed no major differences between the groups. Likewise, in-hospital mortality rate did not differ significantly (<i>p</i> = 0.680) between both groups. Based on our data, sex has no impact on deep wound infection prevalence after cardiac surgery.https://www.mdpi.com/2077-0383/11/24/7510deep sternal wound infectioncardiac surgerysexVAC therapy |
| spellingShingle | Ihor Krasivskyi Borko Ivanov Kaveh Eghbalzadeh Frederike Fehlau Stephen Gerfer Clara Großmann Ahmed Elderia Anton Sabashnikov Parwis Baradaran Rahmanian Navid Mader Ilija Djordjevic Thorsten Wahlers Sex-Associated Differences in Short-Term Outcomes in Patients with Deep Sternal Wound Infection after Open-Heart Surgery Journal of Clinical Medicine deep sternal wound infection cardiac surgery sex VAC therapy |
| title | Sex-Associated Differences in Short-Term Outcomes in Patients with Deep Sternal Wound Infection after Open-Heart Surgery |
| title_full | Sex-Associated Differences in Short-Term Outcomes in Patients with Deep Sternal Wound Infection after Open-Heart Surgery |
| title_fullStr | Sex-Associated Differences in Short-Term Outcomes in Patients with Deep Sternal Wound Infection after Open-Heart Surgery |
| title_full_unstemmed | Sex-Associated Differences in Short-Term Outcomes in Patients with Deep Sternal Wound Infection after Open-Heart Surgery |
| title_short | Sex-Associated Differences in Short-Term Outcomes in Patients with Deep Sternal Wound Infection after Open-Heart Surgery |
| title_sort | sex associated differences in short term outcomes in patients with deep sternal wound infection after open heart surgery |
| topic | deep sternal wound infection cardiac surgery sex VAC therapy |
| url | https://www.mdpi.com/2077-0383/11/24/7510 |
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