Transmission of Zika virus through breast milk and other breastfeeding-related bodily-fluids: A systematic review.
BACKGROUND:Zika virus (ZIKV) infection is an emerging mosquito-borne disease, which is associated with an increase in central nervous system malformations and newborn microcephaly cases. This review investigated evidence of breastfeeding transmission from ZIKV-infected mothers to their children and...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2017-04-01
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| Series: | PLoS Neglected Tropical Diseases |
| Online Access: | http://europepmc.org/articles/PMC5398716?pdf=render |
| _version_ | 1818480880746758144 |
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| author | Susannah Colt Maria N Garcia-Casal Juan Pablo Peña-Rosas Julia L Finkelstein Pura Rayco-Solon Zita C Weise Prinzo Saurabh Mehta |
| author_facet | Susannah Colt Maria N Garcia-Casal Juan Pablo Peña-Rosas Julia L Finkelstein Pura Rayco-Solon Zita C Weise Prinzo Saurabh Mehta |
| author_sort | Susannah Colt |
| collection | DOAJ |
| description | BACKGROUND:Zika virus (ZIKV) infection is an emerging mosquito-borne disease, which is associated with an increase in central nervous system malformations and newborn microcephaly cases. This review investigated evidence of breastfeeding transmission from ZIKV-infected mothers to their children and the presence of ZIKV infection in breastfeeding-related fluids. METHODOLOGY/PRINCIPAL FINDINGS:We conducted a systematic review of observational studies, case studies, and surveillance reports involving breastfeeding women with ZIKV infection in several international databases. Data extraction and analysis were conducted following a PROSPERO-registered protocol. From 472 non-duplicate records, two case reports met criteria for inclusion. We reviewed three cases of ZIKV infection among lactating mothers near the time of delivery. Two of the three (2/3) associated newborns had evidence of ZIKV infection. ZIKV was detected in breast milk of all three mothers. Breast milk detection results were positive in all mothers (3/3) by RT-PCR, one was positive by culture (1/3), and none was tested for ZIKV-specific antibodies. Serum samples were ZIKV positive in all mothers (3/3), and sweat was not tested for ZIKV. CONCLUSIONS/SIGNIFICANCE:We describe three cases of ZIKV-infected breastfeeding mothers who were symptomatic within three days of delivery, and two cases with ZIKV-infected newborns. While ZIKV was detected in the breast milk of all three mothers, the data are not sufficient to conclude ZIKV transmission via breastfeeding. More evidence is needed to distinguish breastfeeding transmission from other perinatal transmission routes. |
| first_indexed | 2024-12-10T11:28:05Z |
| format | Article |
| id | doaj.art-ac0ae7e03da141f0af69969c0ba7161e |
| institution | Directory Open Access Journal |
| issn | 1935-2727 1935-2735 |
| language | English |
| last_indexed | 2024-12-10T11:28:05Z |
| publishDate | 2017-04-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Neglected Tropical Diseases |
| spelling | doaj.art-ac0ae7e03da141f0af69969c0ba7161e2022-12-22T01:50:41ZengPublic Library of Science (PLoS)PLoS Neglected Tropical Diseases1935-27271935-27352017-04-01114e000552810.1371/journal.pntd.0005528Transmission of Zika virus through breast milk and other breastfeeding-related bodily-fluids: A systematic review.Susannah ColtMaria N Garcia-CasalJuan Pablo Peña-RosasJulia L FinkelsteinPura Rayco-SolonZita C Weise PrinzoSaurabh MehtaBACKGROUND:Zika virus (ZIKV) infection is an emerging mosquito-borne disease, which is associated with an increase in central nervous system malformations and newborn microcephaly cases. This review investigated evidence of breastfeeding transmission from ZIKV-infected mothers to their children and the presence of ZIKV infection in breastfeeding-related fluids. METHODOLOGY/PRINCIPAL FINDINGS:We conducted a systematic review of observational studies, case studies, and surveillance reports involving breastfeeding women with ZIKV infection in several international databases. Data extraction and analysis were conducted following a PROSPERO-registered protocol. From 472 non-duplicate records, two case reports met criteria for inclusion. We reviewed three cases of ZIKV infection among lactating mothers near the time of delivery. Two of the three (2/3) associated newborns had evidence of ZIKV infection. ZIKV was detected in breast milk of all three mothers. Breast milk detection results were positive in all mothers (3/3) by RT-PCR, one was positive by culture (1/3), and none was tested for ZIKV-specific antibodies. Serum samples were ZIKV positive in all mothers (3/3), and sweat was not tested for ZIKV. CONCLUSIONS/SIGNIFICANCE:We describe three cases of ZIKV-infected breastfeeding mothers who were symptomatic within three days of delivery, and two cases with ZIKV-infected newborns. While ZIKV was detected in the breast milk of all three mothers, the data are not sufficient to conclude ZIKV transmission via breastfeeding. More evidence is needed to distinguish breastfeeding transmission from other perinatal transmission routes.http://europepmc.org/articles/PMC5398716?pdf=render |
| spellingShingle | Susannah Colt Maria N Garcia-Casal Juan Pablo Peña-Rosas Julia L Finkelstein Pura Rayco-Solon Zita C Weise Prinzo Saurabh Mehta Transmission of Zika virus through breast milk and other breastfeeding-related bodily-fluids: A systematic review. PLoS Neglected Tropical Diseases |
| title | Transmission of Zika virus through breast milk and other breastfeeding-related bodily-fluids: A systematic review. |
| title_full | Transmission of Zika virus through breast milk and other breastfeeding-related bodily-fluids: A systematic review. |
| title_fullStr | Transmission of Zika virus through breast milk and other breastfeeding-related bodily-fluids: A systematic review. |
| title_full_unstemmed | Transmission of Zika virus through breast milk and other breastfeeding-related bodily-fluids: A systematic review. |
| title_short | Transmission of Zika virus through breast milk and other breastfeeding-related bodily-fluids: A systematic review. |
| title_sort | transmission of zika virus through breast milk and other breastfeeding related bodily fluids a systematic review |
| url | http://europepmc.org/articles/PMC5398716?pdf=render |
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