Pharmacophore Modeling and 3D-QSAR Study of Indole and Isatin Derivatives as Antiamyloidogenic Agents Targeting Alzheimer’s Disease

Pharmacophore Modeling and 3D-QSAR Study of Indole and Isatin Derivatives as Antiamyloidogenic Agents Targeting Alzheimer’s Disease

Thirty-six novel indole-containing compounds, mainly 3-(2-phenylhydrazono) isatins and structurally related 1<i>H</i>-indole-3-carbaldehyde derivatives, were synthesized and assayed as inhibitors of beta amyloid (Aβ) aggregation, a hallmark of pathophysiology of Alzheimer’s disease. The...

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Bibliographic Details
Main Authors: Rosa Purgatorio, Nicola Gambacorta, Marco Catto, Modesto de Candia, Leonardo Pisani, Alba Espargaró, Raimon Sabaté, Saverio Cellamare, Orazio Nicolotti, Cosimo D. Altomare
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Molecules
Subjects:
isatin hydrazones
indole derivatives
antiamyloid agents
multitarget-directed ligands
3D-QSAR
Online Access:https://www.mdpi.com/1420-3049/25/23/5773

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