Endometrial stem cells alleviate cisplatin-induced ferroptosis of granulosa cells by regulating Nrf2 expression

Endometrial stem cells alleviate cisplatin-induced ferroptosis of granulosa cells by regulating Nrf2 expression

Abstract Background Premature ovarian failure (POF) caused by cisplatin is a severe and intractable sequela for young women with cancer who received chemotherapy. Cisplatin causes the dysfunction of granulosa cells and mainly leads to but is not limited to its apoptosis and autophagy. Ferroptosis ha...

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Bibliographic Details
Main Authors: Rumeng Pan, Rongli Wang, Feiyan Cheng, Lihui Wang, Zhiwei Cui, Jing She, Xinyuan Yang
Format: Article
Language:English
Published: BMC 2024-04-01
Series:Reproductive Biology and Endocrinology
Subjects:
Ferroptosis
Premature ovarian failure
Endometrial stem cells
Nrf2
Ferrostatin-1
Online Access:https://doi.org/10.1186/s12958-024-01208-8

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