DNA methylation at individual CpG-sites of EPB41L3, HTERT and FAM19A4 are useful for detection of cervical high-grade squamous intraepithelial lesions (HSIL) or worse: Analysis of individual CpG-sites outperforms averaging

DNA methylation at individual CpG-sites of EPB41L3, HTERT and FAM19A4 are useful for detection of cervical high-grade squamous intraepithelial lesions (HSIL) or worse: Analysis of individual CpG-sites outperforms averaging

Global methylation analysis of gene promoters is promising for detection of high-grade squamous intraepithelial lesions or worse (HSIL+) in high-risk human papillomavirus (hrHPV)-positive women. However, diagnostic performance of methylation data at individual CpG-sites is limited. We explored methy...

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Autors principals: Monica Molano, Dorothy A. Machalek, Samuel Phillips, Grace Tan, Suzanne M. Garland, David Hawkes, Prisha Balgovind, Reza Haqshenas, Steve G. Badman, John Bolnga, Josephine Gabuzzi, Zure Kombati, Gloria M. Munnull, Julia ML. Brotherton, Marion Saville, John M. Kaldor, Pamela J. Toliman, Andrew J. Vallely, Gerald L. Murray
Format: Article
Idioma:English
Publicat: Elsevier 2024-12-01
Col·lecció:Tumour Virus Research
Matèries:
DNA methylation
Cervical cancer
Human papillomavirus
Diagnostic test
Epigenetics
Molecular diagnostics
Accés en línia:http://www.sciencedirect.com/science/article/pii/S2666679024000120

Internet

http://www.sciencedirect.com/science/article/pii/S2666679024000120

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