EFFICACY OF ABATACEPT IN A PATIENT WITH POLYARTICULAR JUVENILE IDIOPATHIC ARTHRITIS REFRACTORY TO TNF-α
The article describes the experience of the application of genetically engineered biological drug and an inhibitor of T lymphocyte costimulation – abatacept – at a standard dose in a child with polyarticular juvenile idiopathic arthritis. The disease was characterized by the development of uveitis,...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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"Paediatrician" Publishers LLC
2015-04-01
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| Series: | Вопросы современной педиатрии |
| Subjects: | |
| Online Access: | https://vsp.spr-journal.ru/jour/article/view/76 |
| _version_ | 1826562122794926080 |
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| author | Yu. M. Spivakovskii Yu. V. Chernenkov A. Yu. Spivakovskaya O. V. Skupova E. N. Shul'gina |
| author_facet | Yu. M. Spivakovskii Yu. V. Chernenkov A. Yu. Spivakovskaya O. V. Skupova E. N. Shul'gina |
| author_sort | Yu. M. Spivakovskii |
| collection | DOAJ |
| description | The article describes the experience of the application of genetically engineered biological drug and an inhibitor of T lymphocyte costimulation – abatacept – at a standard dose in a child with polyarticular juvenile idiopathic arthritis. The disease was characterized by the development of uveitis, as well as the ineffectiveness of two inhibitors of tumour necrosis factor α treatment. Successful relief of acute inflammatory reaction of the joints on the background of the normalization of laboratory indicators of disease severity in the application of abatacept in combination with methotrexate was detected. The study gave the characteristics of the dynamics of clinical recovery of the patient and described the dynamic changes of clinical and laboratory symptoms. A steady improvement of the child under nine-month follow-up on the background of the selected scheme basic anti-inflammatory therapy should be noted. |
| first_indexed | 2024-03-12T04:56:58Z |
| format | Article |
| id | doaj.art-ac0d587056684f4fbf2805862f8a8e5c |
| institution | Directory Open Access Journal |
| issn | 1682-5527 1682-5535 |
| language | English |
| last_indexed | 2025-03-14T09:43:03Z |
| publishDate | 2015-04-01 |
| publisher | "Paediatrician" Publishers LLC |
| record_format | Article |
| series | Вопросы современной педиатрии |
| spelling | doaj.art-ac0d587056684f4fbf2805862f8a8e5c2025-03-02T11:33:59Zeng"Paediatrician" Publishers LLCВопросы современной педиатрии1682-55271682-55352015-04-0114230530810.15690/vsp.v14i2.130476EFFICACY OF ABATACEPT IN A PATIENT WITH POLYARTICULAR JUVENILE IDIOPATHIC ARTHRITIS REFRACTORY TO TNF-αYu. M. Spivakovskii0Yu. V. Chernenkov1A. Yu. Spivakovskaya2O. V. Skupova3E. N. Shul'gina4V.I. Razumovskii Saratov State Medical University, Saratov, Russian FederationV.I. Razumovskii Saratov State Medical University, Saratov, Russian FederationV.I. Razumovskii Saratov State Medical University, Saratov, Russian FederationV.I. Razumovskii Saratov State Medical University, Saratov, Russian FederationV.I. Razumovskii Saratov State Medical University, Saratov, Russian FederationThe article describes the experience of the application of genetically engineered biological drug and an inhibitor of T lymphocyte costimulation – abatacept – at a standard dose in a child with polyarticular juvenile idiopathic arthritis. The disease was characterized by the development of uveitis, as well as the ineffectiveness of two inhibitors of tumour necrosis factor α treatment. Successful relief of acute inflammatory reaction of the joints on the background of the normalization of laboratory indicators of disease severity in the application of abatacept in combination with methotrexate was detected. The study gave the characteristics of the dynamics of clinical recovery of the patient and described the dynamic changes of clinical and laboratory symptoms. A steady improvement of the child under nine-month follow-up on the background of the selected scheme basic anti-inflammatory therapy should be noted.https://vsp.spr-journal.ru/jour/article/view/76juvenile idiopathic arthritisbiological drugsabatacept |
| spellingShingle | Yu. M. Spivakovskii Yu. V. Chernenkov A. Yu. Spivakovskaya O. V. Skupova E. N. Shul'gina EFFICACY OF ABATACEPT IN A PATIENT WITH POLYARTICULAR JUVENILE IDIOPATHIC ARTHRITIS REFRACTORY TO TNF-α Вопросы современной педиатрии juvenile idiopathic arthritis biological drugs abatacept |
| title | EFFICACY OF ABATACEPT IN A PATIENT WITH POLYARTICULAR JUVENILE IDIOPATHIC ARTHRITIS REFRACTORY TO TNF-α |
| title_full | EFFICACY OF ABATACEPT IN A PATIENT WITH POLYARTICULAR JUVENILE IDIOPATHIC ARTHRITIS REFRACTORY TO TNF-α |
| title_fullStr | EFFICACY OF ABATACEPT IN A PATIENT WITH POLYARTICULAR JUVENILE IDIOPATHIC ARTHRITIS REFRACTORY TO TNF-α |
| title_full_unstemmed | EFFICACY OF ABATACEPT IN A PATIENT WITH POLYARTICULAR JUVENILE IDIOPATHIC ARTHRITIS REFRACTORY TO TNF-α |
| title_short | EFFICACY OF ABATACEPT IN A PATIENT WITH POLYARTICULAR JUVENILE IDIOPATHIC ARTHRITIS REFRACTORY TO TNF-α |
| title_sort | efficacy of abatacept in a patient with polyarticular juvenile idiopathic arthritis refractory to tnf α |
| topic | juvenile idiopathic arthritis biological drugs abatacept |
| url | https://vsp.spr-journal.ru/jour/article/view/76 |
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