Potential effect of dietary zinc intake on telomere length: A cross-sectional study of US adults
BackgroundTelomere length, which is related to chronic diseases and premature mortality, is influenced by dietary factors. Zinc is known as a dietary antioxidant micronutrient, however, its impact on telomere length remains unclear.ObjectiveWe aimed to examine the potential effect of dietary zinc in...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-11-01
|
| Series: | Frontiers in Nutrition |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2022.993425/full |
| _version_ | 1811225260839665664 |
|---|---|
| author | Huanchen Shi Xiaoxuan Li Haihong Yu Wanting Shi Yue Lin Yunping Zhou |
| author_facet | Huanchen Shi Xiaoxuan Li Haihong Yu Wanting Shi Yue Lin Yunping Zhou |
| author_sort | Huanchen Shi |
| collection | DOAJ |
| description | BackgroundTelomere length, which is related to chronic diseases and premature mortality, is influenced by dietary factors. Zinc is known as a dietary antioxidant micronutrient, however, its impact on telomere length remains unclear.ObjectiveWe aimed to examine the potential effect of dietary zinc intake on telomere length among middle-aged and older individuals in the US.Materials and methodsOur study included 3,793 US participants aged 45 years and older from the 1999 to 2002 National Health and Nutrition Examination Survey (NHANES). 24-h dietary recall interviews were employed to evaluate zinc consumption. Leukocyte telomere length was assessed by real-time quantitative polymerase chain reaction (qPCR). We adopted generalized linear models to investigate the effect of dietary zinc intake on telomere length, and subgroup analyses were further applied. We further evaluated the dose-response relationship using restricted cubic spline analysis.ResultsAmong the 3,793 participants, the average telomere length was 0.926 ± 0.205 (T/S ratio) or 5509.5 ± 494.9 (bp). After adjusting for major confounders, every 5 mg increment in dietary zinc consumption was related to 0.64% (95% CI: 0.17%, 1.10%) longer telomere length. In the subgroup analyses, significant relationships were found in females (Percentage change: 1.11%; 95% CI: 0.48%, 1.75%), obese (Percentage change: 0.88%; 95% CI: 0.26%, 1.50%), and low energy intake individuals (Percentage change: 0.99%; 95% CI: 0.51%, 1.46%). Additionally, we revealed a positive linear relationship between dietary zinc intake and telomere length (P for non-linearity = 0.636).ConclusionOur study revealed that elevated dietary zinc intake was significantly related to longer telomere length among adults aged 45 years and older in the US. And the association was more pronounced in females, obese, and low energy intake individuals. |
| first_indexed | 2024-04-12T09:02:52Z |
| format | Article |
| id | doaj.art-ac0dde9f68de460b865f07b63e11074d |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-04-12T09:02:52Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-ac0dde9f68de460b865f07b63e11074d2022-12-22T03:39:10ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2022-11-01910.3389/fnut.2022.993425993425Potential effect of dietary zinc intake on telomere length: A cross-sectional study of US adultsHuanchen Shi0Xiaoxuan Li1Haihong Yu2Wanting Shi3Yue Lin4Yunping Zhou5School of Medicine, Qingdao University, Qingdao, ChinaSchool of Medicine, Qingdao University, Qingdao, ChinaSchool of Medicine, Qingdao University, Qingdao, ChinaSchool of Medicine, Qingdao University, Qingdao, ChinaSchool of Medicine, Qingdao University, Qingdao, ChinaSchool of Nursing, Qingdao University, Qingdao, ChinaBackgroundTelomere length, which is related to chronic diseases and premature mortality, is influenced by dietary factors. Zinc is known as a dietary antioxidant micronutrient, however, its impact on telomere length remains unclear.ObjectiveWe aimed to examine the potential effect of dietary zinc intake on telomere length among middle-aged and older individuals in the US.Materials and methodsOur study included 3,793 US participants aged 45 years and older from the 1999 to 2002 National Health and Nutrition Examination Survey (NHANES). 24-h dietary recall interviews were employed to evaluate zinc consumption. Leukocyte telomere length was assessed by real-time quantitative polymerase chain reaction (qPCR). We adopted generalized linear models to investigate the effect of dietary zinc intake on telomere length, and subgroup analyses were further applied. We further evaluated the dose-response relationship using restricted cubic spline analysis.ResultsAmong the 3,793 participants, the average telomere length was 0.926 ± 0.205 (T/S ratio) or 5509.5 ± 494.9 (bp). After adjusting for major confounders, every 5 mg increment in dietary zinc consumption was related to 0.64% (95% CI: 0.17%, 1.10%) longer telomere length. In the subgroup analyses, significant relationships were found in females (Percentage change: 1.11%; 95% CI: 0.48%, 1.75%), obese (Percentage change: 0.88%; 95% CI: 0.26%, 1.50%), and low energy intake individuals (Percentage change: 0.99%; 95% CI: 0.51%, 1.46%). Additionally, we revealed a positive linear relationship between dietary zinc intake and telomere length (P for non-linearity = 0.636).ConclusionOur study revealed that elevated dietary zinc intake was significantly related to longer telomere length among adults aged 45 years and older in the US. And the association was more pronounced in females, obese, and low energy intake individuals.https://www.frontiersin.org/articles/10.3389/fnut.2022.993425/fulldietary zinc intaketelomere lengthoxidative stressinflammationagingNHANES |
| spellingShingle | Huanchen Shi Xiaoxuan Li Haihong Yu Wanting Shi Yue Lin Yunping Zhou Potential effect of dietary zinc intake on telomere length: A cross-sectional study of US adults Frontiers in Nutrition dietary zinc intake telomere length oxidative stress inflammation aging NHANES |
| title | Potential effect of dietary zinc intake on telomere length: A cross-sectional study of US adults |
| title_full | Potential effect of dietary zinc intake on telomere length: A cross-sectional study of US adults |
| title_fullStr | Potential effect of dietary zinc intake on telomere length: A cross-sectional study of US adults |
| title_full_unstemmed | Potential effect of dietary zinc intake on telomere length: A cross-sectional study of US adults |
| title_short | Potential effect of dietary zinc intake on telomere length: A cross-sectional study of US adults |
| title_sort | potential effect of dietary zinc intake on telomere length a cross sectional study of us adults |
| topic | dietary zinc intake telomere length oxidative stress inflammation aging NHANES |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2022.993425/full |
| work_keys_str_mv | AT huanchenshi potentialeffectofdietaryzincintakeontelomerelengthacrosssectionalstudyofusadults AT xiaoxuanli potentialeffectofdietaryzincintakeontelomerelengthacrosssectionalstudyofusadults AT haihongyu potentialeffectofdietaryzincintakeontelomerelengthacrosssectionalstudyofusadults AT wantingshi potentialeffectofdietaryzincintakeontelomerelengthacrosssectionalstudyofusadults AT yuelin potentialeffectofdietaryzincintakeontelomerelengthacrosssectionalstudyofusadults AT yunpingzhou potentialeffectofdietaryzincintakeontelomerelengthacrosssectionalstudyofusadults |