An amino-terminal fragment of apolipoprotein E4 leads to behavioral deficits, increased PHF-1 immunoreactivity, and mortality in zebrafish.

Although the increased risk of developing sporadic Alzheimer's disease (AD) associated with the inheritance of the apolipoprotein E4 (APOE4) allele is well characterized, the molecular underpinnings of how ApoE4 imparts risk remains unknown. Enhanced proteolysis of the ApoE4 protein with a toxi...

Full description

Bibliographic Details
Main Authors:	Madyson M McCarthy, Makenna J Hardy, Saylor E Leising, Alex M LaFollette, Erica S Stewart, Amelia S Cogan, Tanya Sanghal, Katie Matteo, Jonathon C Reeck, Julia T Oxford, Troy T Rohn
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2022-01-01
Series:	PLoS ONE
Online Access:	https://doi.org/10.1371/journal.pone.0271707

An amino-terminal fragment of apolipoprotein E4 leads to behavioral deficits, increased PHF-1 immunoreactivity, and mortality in zebrafish by Madyson M. McCarthy, Makenna J. Hardy, Saylor E. Leising, Alex M. LaFollette, Erica S. Stewart, Amelia S. Cogan, Tanya Sanghal, Katie Matteo, Jonathon C. Reeck, Julia T. Oxford, Troy T. Rohn

Published 2022-01-01

Get full text

Article

An amino-terminal fragment of apolipoprotein E4 leads to behavioral deficits, increased PHF-1 immunoreactivity, and mortality in zebrafish.

Similar Items