Potential Mechanisms of Plant-Derived Natural Products in the Treatment of Cervical Cancer
Cervical cancer is the second most common gynecological malignancy globally; it seriously endangers women’s health because of its high morbidity and mortality. Conventional treatments are prone to drug resistance, recurrence and metastasis. Therefore, there is an urgent need to develop new drugs wit...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-10-01
|
| Series: | Biomolecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-273X/11/10/1539 |
| _version_ | 1797515169750843392 |
|---|---|
| author | Meizhu He Lijie Xia Jinyao Li |
| author_facet | Meizhu He Lijie Xia Jinyao Li |
| author_sort | Meizhu He |
| collection | DOAJ |
| description | Cervical cancer is the second most common gynecological malignancy globally; it seriously endangers women’s health because of its high morbidity and mortality. Conventional treatments are prone to drug resistance, recurrence and metastasis. Therefore, there is an urgent need to develop new drugs with high efficacy and low side effects to prevent and treat cervical cancer. In recent years, plant-derived natural products have been evaluated as potential anticancer drugs that preferentially kill tumor cells without severe adverse effects. A growing number of studies have shown that natural products can achieve practical anti-cervical-cancer effects through multiple mechanisms, including inhibition of tumor-cell proliferation, induction of apoptosis, suppression of angiogenesis and telomerase activity, enhancement of immunity and reversal of multidrug resistance. This paper reviews the therapeutic effects and mechanisms of plant-derived natural products on cervical cancer and provides references for developing anti-cervical-cancer drugs with high efficacy and low side effects. |
| first_indexed | 2024-03-10T06:42:40Z |
| format | Article |
| id | doaj.art-ac11471744894524814ece1c220cde6f |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-10T06:42:40Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-ac11471744894524814ece1c220cde6f2023-11-22T17:35:10ZengMDPI AGBiomolecules2218-273X2021-10-011110153910.3390/biom11101539Potential Mechanisms of Plant-Derived Natural Products in the Treatment of Cervical CancerMeizhu He0Lijie Xia1Jinyao Li2Xinjiang Key Laboratory of Biological Resources and Genetic Engineering, College of Life Science and Technology, Xinjiang University, Urumqi 830017, ChinaXinjiang Key Laboratory of Biological Resources and Genetic Engineering, College of Life Science and Technology, Xinjiang University, Urumqi 830017, ChinaXinjiang Key Laboratory of Biological Resources and Genetic Engineering, College of Life Science and Technology, Xinjiang University, Urumqi 830017, ChinaCervical cancer is the second most common gynecological malignancy globally; it seriously endangers women’s health because of its high morbidity and mortality. Conventional treatments are prone to drug resistance, recurrence and metastasis. Therefore, there is an urgent need to develop new drugs with high efficacy and low side effects to prevent and treat cervical cancer. In recent years, plant-derived natural products have been evaluated as potential anticancer drugs that preferentially kill tumor cells without severe adverse effects. A growing number of studies have shown that natural products can achieve practical anti-cervical-cancer effects through multiple mechanisms, including inhibition of tumor-cell proliferation, induction of apoptosis, suppression of angiogenesis and telomerase activity, enhancement of immunity and reversal of multidrug resistance. This paper reviews the therapeutic effects and mechanisms of plant-derived natural products on cervical cancer and provides references for developing anti-cervical-cancer drugs with high efficacy and low side effects.https://www.mdpi.com/2218-273X/11/10/1539plant-derived natural productscervical cancermolecular mechanismstreatment |
| spellingShingle | Meizhu He Lijie Xia Jinyao Li Potential Mechanisms of Plant-Derived Natural Products in the Treatment of Cervical Cancer Biomolecules plant-derived natural products cervical cancer molecular mechanisms treatment |
| title | Potential Mechanisms of Plant-Derived Natural Products in the Treatment of Cervical Cancer |
| title_full | Potential Mechanisms of Plant-Derived Natural Products in the Treatment of Cervical Cancer |
| title_fullStr | Potential Mechanisms of Plant-Derived Natural Products in the Treatment of Cervical Cancer |
| title_full_unstemmed | Potential Mechanisms of Plant-Derived Natural Products in the Treatment of Cervical Cancer |
| title_short | Potential Mechanisms of Plant-Derived Natural Products in the Treatment of Cervical Cancer |
| title_sort | potential mechanisms of plant derived natural products in the treatment of cervical cancer |
| topic | plant-derived natural products cervical cancer molecular mechanisms treatment |
| url | https://www.mdpi.com/2218-273X/11/10/1539 |
| work_keys_str_mv | AT meizhuhe potentialmechanismsofplantderivednaturalproductsinthetreatmentofcervicalcancer AT lijiexia potentialmechanismsofplantderivednaturalproductsinthetreatmentofcervicalcancer AT jinyaoli potentialmechanismsofplantderivednaturalproductsinthetreatmentofcervicalcancer |