Influence of Olive Oil and Its Components on Breast Cancer: Molecular Mechanisms
Breast cancer is the most frequent malignant neoplasia and a leading cause of mortality in women worldwide. The Mediterranean diet has been proposed as a healthy dietary pattern with protective effects in several chronic diseases, including breast cancer. This diet is characterized by the consumptio...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-01-01
|
| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/27/2/477 |
| _version_ | 1797491571588857856 |
|---|---|
| author | Raquel Moral Eduard Escrich |
| author_facet | Raquel Moral Eduard Escrich |
| author_sort | Raquel Moral |
| collection | DOAJ |
| description | Breast cancer is the most frequent malignant neoplasia and a leading cause of mortality in women worldwide. The Mediterranean diet has been proposed as a healthy dietary pattern with protective effects in several chronic diseases, including breast cancer. This diet is characterized by the consumption of abundant plant foods and olive oil as the principal source of fat, which is considered one of the main components with potential antioxidant, anti-inflammatory and anticancer effects. Extra-virgin olive oil (EVOO) has several bioactive compounds, mainly including monounsaturated fatty acids, triterpenes and polyphenols, such as phenolic alcohols (e.g., hydroxytyrosol), secoiridoids (e.g., oleuropein and oleocanthal), lignans (e.g., pinoresinol) or flavonoids (e.g., luteolin). While epidemiological evidence is still limited, experimental in vivo and in vitro data have shown a protective effect of this oil and its compounds on mammary carcinogenesis. Such effects account through complex and multiple mechanisms, including changes in epigenetics, transcriptome and protein expression that modulate several signaling pathways. Molecular targets of EVOO compounds have a role in the acquisition of cancer hallmarks. Although further research is needed to elucidate their beneficial effects on human prevention and progression of the disease, evidence points to EVOO in the context of the Mediterranean diet as a heathy choice, while EVOO components may be promising adjuvants in anticancer strategies. |
| first_indexed | 2024-03-10T00:50:12Z |
| format | Article |
| id | doaj.art-ac1172b158f149b488375ce404ce914f |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T00:50:12Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-ac1172b158f149b488375ce404ce914f2023-11-23T14:52:32ZengMDPI AGMolecules1420-30492022-01-0127247710.3390/molecules27020477Influence of Olive Oil and Its Components on Breast Cancer: Molecular MechanismsRaquel Moral0Eduard Escrich1Department of Cell Biology, Physiology and Immunology, Faculty of Medicine, Universitat Autònoma de Barcelona, 08193 Bellaterra, SpainDepartment of Cell Biology, Physiology and Immunology, Faculty of Medicine, Universitat Autònoma de Barcelona, 08193 Bellaterra, SpainBreast cancer is the most frequent malignant neoplasia and a leading cause of mortality in women worldwide. The Mediterranean diet has been proposed as a healthy dietary pattern with protective effects in several chronic diseases, including breast cancer. This diet is characterized by the consumption of abundant plant foods and olive oil as the principal source of fat, which is considered one of the main components with potential antioxidant, anti-inflammatory and anticancer effects. Extra-virgin olive oil (EVOO) has several bioactive compounds, mainly including monounsaturated fatty acids, triterpenes and polyphenols, such as phenolic alcohols (e.g., hydroxytyrosol), secoiridoids (e.g., oleuropein and oleocanthal), lignans (e.g., pinoresinol) or flavonoids (e.g., luteolin). While epidemiological evidence is still limited, experimental in vivo and in vitro data have shown a protective effect of this oil and its compounds on mammary carcinogenesis. Such effects account through complex and multiple mechanisms, including changes in epigenetics, transcriptome and protein expression that modulate several signaling pathways. Molecular targets of EVOO compounds have a role in the acquisition of cancer hallmarks. Although further research is needed to elucidate their beneficial effects on human prevention and progression of the disease, evidence points to EVOO in the context of the Mediterranean diet as a heathy choice, while EVOO components may be promising adjuvants in anticancer strategies.https://www.mdpi.com/1420-3049/27/2/477olive oilEVOObreast cancerminor compoundsapoptosisproliferation |
| spellingShingle | Raquel Moral Eduard Escrich Influence of Olive Oil and Its Components on Breast Cancer: Molecular Mechanisms Molecules olive oil EVOO breast cancer minor compounds apoptosis proliferation |
| title | Influence of Olive Oil and Its Components on Breast Cancer: Molecular Mechanisms |
| title_full | Influence of Olive Oil and Its Components on Breast Cancer: Molecular Mechanisms |
| title_fullStr | Influence of Olive Oil and Its Components on Breast Cancer: Molecular Mechanisms |
| title_full_unstemmed | Influence of Olive Oil and Its Components on Breast Cancer: Molecular Mechanisms |
| title_short | Influence of Olive Oil and Its Components on Breast Cancer: Molecular Mechanisms |
| title_sort | influence of olive oil and its components on breast cancer molecular mechanisms |
| topic | olive oil EVOO breast cancer minor compounds apoptosis proliferation |
| url | https://www.mdpi.com/1420-3049/27/2/477 |
| work_keys_str_mv | AT raquelmoral influenceofoliveoilanditscomponentsonbreastcancermolecularmechanisms AT eduardescrich influenceofoliveoilanditscomponentsonbreastcancermolecularmechanisms |