Control of Plant Viruses by CRISPR/Cas System-Mediated Adaptive Immunity
Plant diseases caused by invading plant viruses pose serious threats to agricultural production in the world, and the antiviral engineering initiated by molecular biotechnology has been an effective strategy to prevent and control plant viruses. Recent advances in clustered regularly interspaced sho...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-10-01
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| Series: | Frontiers in Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2020.593700/full |
| _version_ | 1818239733707309056 |
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| author | Yongsen Cao Huanbin Zhou Xueping Zhou Xueping Zhou Fangfang Li |
| author_facet | Yongsen Cao Huanbin Zhou Xueping Zhou Xueping Zhou Fangfang Li |
| author_sort | Yongsen Cao |
| collection | DOAJ |
| description | Plant diseases caused by invading plant viruses pose serious threats to agricultural production in the world, and the antiviral engineering initiated by molecular biotechnology has been an effective strategy to prevent and control plant viruses. Recent advances in clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated (Cas) system-mediated DNA or RNA editing/interference in plants make them very attractive tools applicable to the plant protection field. Here, we review the development of CRISPR/Cas systems and summarize their applications in controlling different plant viruses by targeting viral sequences or host susceptibility genes. We list some potential recessive resistance genes that can be utilized in antiviral breeding and emphasize the importance and promise of recessive resistance gene-based antiviral breeding to generate transgene-free plants without developmental defects. Finally, we discuss the challenges and opportunities for the application of CRISPR/Cas techniques in the prevention and control of plant viruses in the field. |
| first_indexed | 2024-12-12T13:02:15Z |
| format | Article |
| id | doaj.art-ac127797d4fd46fb9b0dc163cb25016b |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-12-12T13:02:15Z |
| publishDate | 2020-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-ac127797d4fd46fb9b0dc163cb25016b2022-12-22T00:23:46ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2020-10-011110.3389/fmicb.2020.593700593700Control of Plant Viruses by CRISPR/Cas System-Mediated Adaptive ImmunityYongsen Cao0Huanbin Zhou1Xueping Zhou2Xueping Zhou3Fangfang Li4State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing, ChinaState Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing, ChinaState Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing, ChinaState Key Laboratory of Rice Biology, Institute of Biotechnology, Zhejiang University, Hangzhou, Zhejiang, ChinaState Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing, ChinaPlant diseases caused by invading plant viruses pose serious threats to agricultural production in the world, and the antiviral engineering initiated by molecular biotechnology has been an effective strategy to prevent and control plant viruses. Recent advances in clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated (Cas) system-mediated DNA or RNA editing/interference in plants make them very attractive tools applicable to the plant protection field. Here, we review the development of CRISPR/Cas systems and summarize their applications in controlling different plant viruses by targeting viral sequences or host susceptibility genes. We list some potential recessive resistance genes that can be utilized in antiviral breeding and emphasize the importance and promise of recessive resistance gene-based antiviral breeding to generate transgene-free plants without developmental defects. Finally, we discuss the challenges and opportunities for the application of CRISPR/Cas techniques in the prevention and control of plant viruses in the field.https://www.frontiersin.org/articles/10.3389/fmicb.2020.593700/fullCRISPRCas proteinsplant virusrecessive resistance genesantiviral engineering |
| spellingShingle | Yongsen Cao Huanbin Zhou Xueping Zhou Xueping Zhou Fangfang Li Control of Plant Viruses by CRISPR/Cas System-Mediated Adaptive Immunity Frontiers in Microbiology CRISPR Cas proteins plant virus recessive resistance genes antiviral engineering |
| title | Control of Plant Viruses by CRISPR/Cas System-Mediated Adaptive Immunity |
| title_full | Control of Plant Viruses by CRISPR/Cas System-Mediated Adaptive Immunity |
| title_fullStr | Control of Plant Viruses by CRISPR/Cas System-Mediated Adaptive Immunity |
| title_full_unstemmed | Control of Plant Viruses by CRISPR/Cas System-Mediated Adaptive Immunity |
| title_short | Control of Plant Viruses by CRISPR/Cas System-Mediated Adaptive Immunity |
| title_sort | control of plant viruses by crispr cas system mediated adaptive immunity |
| topic | CRISPR Cas proteins plant virus recessive resistance genes antiviral engineering |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2020.593700/full |
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