Effect of folic acid and tetrahydrofolate on tissue arsenic level in rat
Quest is still going on for a cheap, effective, and easily available remedy for chronic arsenic toxicity. This study was designed to investigate the effects of folic acid and tetrahydrofolate in lowering the arsenic burden in tissues. Rats received arsenic at 700 µg/day by gavage for 28 days except...
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| Format: | Article |
| Language: | English |
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Bangladesh Pharmacological Society
2010-06-01
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| Series: | Bangladesh Journal of Pharmacology |
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| Online Access: | http://www.banglajol.info/index.php/BJP/article/view/4909/4052 |
| _version_ | 1811197902734753792 |
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| author | Md. Faizur Rahman Mir Misbahuddin |
| author_facet | Md. Faizur Rahman Mir Misbahuddin |
| author_sort | Md. Faizur Rahman |
| collection | DOAJ |
| description | Quest is still going on for a cheap, effective, and easily available remedy for chronic arsenic toxicity. This study was designed to investigate the effects of folic acid and tetrahydrofolate in lowering the arsenic burden in tissues. Rats received arsenic at 700 µg/day by gavage for 28 days except the control group. Arsenic accumulation was significantly lowered (p<0.05), in liver, kidney, heart, lung and skin in both the folic acid and tetrahydrofolate-treated groups compared to arsenic only treated group. The oxidative stress induced by arsenic treatment was reduced as evident by the reduction in rise of malondialdehyde level in both groups. But folic acid was found to be more efficacious compared to tetrahydrofolate. |
| first_indexed | 2024-04-12T01:21:59Z |
| format | Article |
| id | doaj.art-ac12cce3241d429697d808af21cfe5f2 |
| institution | Directory Open Access Journal |
| issn | 1991-007X 1991-0088 |
| language | English |
| last_indexed | 2024-04-12T01:21:59Z |
| publishDate | 2010-06-01 |
| publisher | Bangladesh Pharmacological Society |
| record_format | Article |
| series | Bangladesh Journal of Pharmacology |
| spelling | doaj.art-ac12cce3241d429697d808af21cfe5f22022-12-22T03:53:45ZengBangladesh Pharmacological SocietyBangladesh Journal of Pharmacology1991-007X1991-00882010-06-01512529Effect of folic acid and tetrahydrofolate on tissue arsenic level in ratMd. Faizur RahmanMir MisbahuddinQuest is still going on for a cheap, effective, and easily available remedy for chronic arsenic toxicity. This study was designed to investigate the effects of folic acid and tetrahydrofolate in lowering the arsenic burden in tissues. Rats received arsenic at 700 µg/day by gavage for 28 days except the control group. Arsenic accumulation was significantly lowered (p<0.05), in liver, kidney, heart, lung and skin in both the folic acid and tetrahydrofolate-treated groups compared to arsenic only treated group. The oxidative stress induced by arsenic treatment was reduced as evident by the reduction in rise of malondialdehyde level in both groups. But folic acid was found to be more efficacious compared to tetrahydrofolate.http://www.banglajol.info/index.php/BJP/article/view/4909/4052ArsenicFolic acidTetrahydrofolate |
| spellingShingle | Md. Faizur Rahman Mir Misbahuddin Effect of folic acid and tetrahydrofolate on tissue arsenic level in rat Bangladesh Journal of Pharmacology Arsenic Folic acid Tetrahydrofolate |
| title | Effect of folic acid and tetrahydrofolate on tissue arsenic level in rat |
| title_full | Effect of folic acid and tetrahydrofolate on tissue arsenic level in rat |
| title_fullStr | Effect of folic acid and tetrahydrofolate on tissue arsenic level in rat |
| title_full_unstemmed | Effect of folic acid and tetrahydrofolate on tissue arsenic level in rat |
| title_short | Effect of folic acid and tetrahydrofolate on tissue arsenic level in rat |
| title_sort | effect of folic acid and tetrahydrofolate on tissue arsenic level in rat |
| topic | Arsenic Folic acid Tetrahydrofolate |
| url | http://www.banglajol.info/index.php/BJP/article/view/4909/4052 |
| work_keys_str_mv | AT mdfaizurrahman effectoffolicacidandtetrahydrofolateontissuearseniclevelinrat AT mirmisbahuddin effectoffolicacidandtetrahydrofolateontissuearseniclevelinrat |